Use of a Novel Arg-Gly-Asp Radioligand,¹⁸F-AH111585, to Determine Changes in Tumor Vascularity After Antitumor Therapy

PET of αvβ3-Integrin and αvβ5-Integrin Expression with 18F-Fluciclatide for Assessment of Response to Targeted Therapy: Ready for Prime Time?

“…In one study, PET with 18 F-AH111585 visualized a reduction in microvessel density during low-dose paclitaxel therapy in an animal model of Lewis lung cell cancer (LLC), but the uptake of 14 C-FDG did not decrease (6). The latter report already hinted that 18 F-AH111585 might have value for the imaging of angiogenesis and might be superior to nonspecific tracers, such as 18 F-FDG.…”

“…Thus, the interpretation of the PET signal for a v b 3 -integrin expression is complex, and the value of imaging of a v b 3 -integrin expression as a genuine biomarker of angiogenesis depends on the tumor type analyzed. However, as mentioned earlier, a study with the LLC model, which expresses a v b 3 -integrin only on endothelial cells and not on tumor cells, also revealed the first promising results for response assessment with 18 F-fluciclatide ( 18 F-AH111585) (6).…”

Role of Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Imaging in Diagnosis and Staging of Lung Cancer

“…Tümör anjiogenezi ile ilişkili olarak aktifleşen endotel hücrelerinde integrin adı verilen moleküllerin ekspresyonu artar. İntegrinlerin görüntülenmesine yönelik F-18 ve Ga-68 ile işaretli çeşitli PET ajanları geliştirilmiş, bu ajanlar kullanılarak akciğer kanserinde anjiogenezin PET ile görüntülenmesine yönelik çalışmalar yapılmıştır (87,88,89). CXCR4 çeşitli solid kanseri türlerinde artmış ekspresyon gösteren, tümörün metastaz yapma potansiyeli ile ilişkili bir kemokin reseptörüdür (90,91).…”

‘Go with the flow ’: A review of methods and advancements in blood flow imaging

“…Micro-CT provides high resolution 3D volumetric data, suitable for analysis, quantification, validation and visualisation of vasculature. Reported studies for the use of micro-CT include the assessment of induced or implanted disease models [251,252]; screening for anatomical abnormalities and/or changes in live animals [253]; assessing angiogenesis during fracture healing [254]; in morphological studies, for example, the rodent renal vasculature [255,256]; and the assessment of cancer staging for predictions of metastatic relapse [257]. Micro-CT has also branched into the realm of fluid dynamic simulations in, for instance, the mouse aorta [258,259] and assessment of coronary artery disease [260].…”