Use of a PCR-Based Assay for Fetal C^wAntigen Genotyping in a Patient with a History of Moderately Severe Hemolytic Disease of the Newborn Due to Anti-C^w

Anti‐Cw alloimmunization presenting as hydrops fetalis

“…It should be noted that both transfusion medicine and neonatal care were poorly developed at that time. Only five other cases, severe enough to require phototherapy and exchange transfusion, have been reported in the English literature besides those reported by Bowman and Pollock [7][8][9][10][11]. We report a case of significant anaemia and hydrops fetalis that could be attributed to anti-C w alloimmunization.…”

“…The antigen is attributable to the RHCE gene on the Rh locus and has recently been characterized at the molecular level as an A to G nucleotide substitution in exon 1 of the gene that encodes the C, c, E and e Rh antigens. This results in a Gln to Arg substitution at amino acid 41 of the RHCE polypeptide [7].…”

Anti- CW: In a Young Female Patient. A Case Report with Review of Literature and Frequency of Low Incidence CW (Rh8) Antigen in North India

“…In 1947, Lawler and Loghem reported first anti C W associated HDN [3]. Since then there have been infrequent case reports on anti C w associated moderate to severe HDN requiring intervention as summarized in Table 3 [3][4][5][6][7][8][9][10][11][12], demonstrating that pregnancies affected by anti C w merit closer scrutiny. Table 4 shows the C w antigen frequency in this study in comparison to that reported from other parts of world.…”