Use of a Porcine Collagen Matrix as an Alternative to Autogenous Tissue for Grafting Oral Soft Tissue Defects

Herford, Alan S.; Akin, Lee; Cicciù, Marco; Maiorana, Carlo; Boyne, Philip J.

doi:10.1016/j.joms.2010.02.054

Cited by 93 publications

(96 citation statements)

References 20 publications

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“…It was observed that collagen membrane had good adaptability to the surgical defect, i.e., it was supple and adapted to the wound no matter what the contour was. 35,36 Based on a study by Natraj et al 37 collagen membrane, though not statistically significant, gave better results compared with BFP with respect to mouth opening, whereas our study also showed collagen to be more efficient, and overall, the results are statistically significant. None of the cases showed any adverse reactions to the collagen, proving its safety as a biological dressing.…”

Section: Graph 5: Epithelialization Rate (Days)contrasting

confidence: 45%

Comparison of Efficacy of Buccal Fat Pad and Collagen Membrane in Surgical Management of Oral Submucous Fibrosis

Randhawa¹,

Randhawa²,

Tiwari³

et al. 2017

IJPCDR

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Background and objectives: Oral submucous fibrosis (OSMF) is a chronic progressive premalignant condition, characterized by gradual trismus of mouth. The study was done to compare the efficacy of buccal fat pad (BFP) and collagen membrane as an interpositional material in surgical management of OSMF and also (1) to assess and compare the mouth opening achieved in both groups of patient; (2) the improvement in flexibility of buccal mucosa in both groups; (3) oral pain and burning sensation on intake of spicy food; (4) the rapidity in epithelialization of graft at the intraoral wound site.

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Section: Graph 5: Epithelialization Rate (Days)contrasting

confidence: 45%

Comparison of Efficacy of Buccal Fat Pad and Collagen Membrane in Surgical Management of Oral Submucous Fibrosis

Randhawa¹,

Randhawa²,

Tiwari³

et al. 2017

IJPCDR

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“…Mucograft ® is a collagen matrix of porcine origin used as a substitute in cases of loss of the connective tissue structure (4,(8)(9)(10)(11)19). It has been used to replace the connective tissue graft from the palate, as well as for recession coverage and regeneration of keratinized mucosa around teeth and implants (4,12,20).…”

Section: Discussionmentioning

confidence: 99%

“…However, these improved histological outcomes had limited clinical significance and not predictably present in all studies (15). Some studies have investigated the clinical and histological outcome of Mucograft ® for procedures surrounding teeth and dental implants (4,8,10,12). The matrix showed acceptable tissue integration, even in open healing conditions.…”

Section: Biological Behavior Of Mucograft® In Fibroblastsmentioning

confidence: 99%

“…A recent study comparing Mucograft ® with BioGuide ® , which is another biomaterial, demonstrated that the former facilitated cell proliferation and promoted early tissue reaction in vitro and in vivo, respectively (7). This matrix has been extensively studied in clinical setting (4,(8)(9)(10), with several studies showing promising esthetic results (4,(9)(10)(11)(12). Additional studies that report on cell proliferation and viability, and the potential to induce connective tissue synthesis are, however, lacking.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of the Biological Behavior of Mucograft® in Human Gingival Fibroblasts: An In Vitro Study

et al. 2015

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Mucograft® is a resorbing porcine matrix composed of type I and type III collagen, used for soft tissue augmentation in guided tissue bony regeneration procedures. This in vitro study aimed to evaluate the biological behavior of Mucograft® in human gingival fibroblasts, as well as the ability of the matrix to induce production of extracellular matrix. Six resorbing Mucograft® matrices (MCG) were cut into 3 x 2 mm rectangles and 5 x 5 mm squares and were placed in 96-and 24-well plates, respectively. The control group (CTRL) consisted of cells plated on polystyrene without the MCG. After one, two, three and seven days, cell proliferation and viability were assessed using the Trypan exclusion method and MTT test, respectively. Type III collagen (COL 3A1) and vimentin (VIM) expression were also evaluated at 10 and 14 days, using Western blotting. Statistical analysis, using ANOVA with post hoc Bonferroni test, revealed that human gingival fibroblasts from MCG showed similar results (p>0.05) for proliferation and viability as the cells cultured on CTRL. After 14 days, a significant decrease in COL 3A1 expression (p<0.05) was observed when cultured with the MCG. VIM expression showed no significant difference at any time period (p>0.05). Although no increase in extracellular matrix secretion was observed in this in vitro study, Mucograft® presented cellular compatibility, being an option for a scaffold whenever it is required.

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“…Recientemente se introdujo (30) una matriz de colágeno bilaminar de origen porcino, dicha matriz consiste en dos capas funcionales: una capa oclusiva de células que está formada en un paquete compacto de fibras colágenas y una capa porosa. Sin embargo, la capa porosa es más gruesa con el propósito de mejorar el tejido queratinizado y así inducir el efecto de crear espacio para favorecer la formación del coágulo sanguíneo.…”

Section: Matriz De Colágeno Bicapa De Origen Porcino (Mucograft®) (Mg)unclassified

Aplicación de biomateriales de base biológica, moléculas bioactivas e ingeniería de tejidos en cirugía plástica periodontal: Una revisión

Yaneth

Alarcón

Velásquez³

2012

Rev. Clin. Periodoncia Implantol. Rehabil. Oral

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Use of a Porcine Collagen Matrix as an Alternative to Autogenous Tissue for Grafting Oral Soft Tissue Defects

Cited by 93 publications

References 20 publications

Comparison of Efficacy of Buccal Fat Pad and Collagen Membrane in Surgical Management of Oral Submucous Fibrosis

Comparison of Efficacy of Buccal Fat Pad and Collagen Membrane in Surgical Management of Oral Submucous Fibrosis

Evaluation of the Biological Behavior of Mucograft® in Human Gingival Fibroblasts: An In Vitro Study

Aplicación de biomateriales de base biológica, moléculas bioactivas e ingeniería de tejidos en cirugía plástica periodontal: Una revisión

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