Use of a portable thermal imaging unit as a rapid, quantitative method of evaluating inflammation and experimental arthritis

Sanchez, Brian; Lesch, Mark E.; Brammer, David W.; Bove, Susan E.; Thiel, Melissa; Kilgore, Kenneth S.

doi:10.1016/j.vascn.2008.01.003

Cited by 37 publications

(25 citation statements)

References 17 publications

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“…Finally, our study is one of the first to use thermal imaging for the evaluation of arthritis in mice (31,32). This method seems to be more sensitive compared with the disease activity score or the paw thickness because it better captured the difference in potency between DEX and CpdA, which was also reflected by the histological parameters of the paw.…”

Section: Discussionmentioning

confidence: 96%

Effects of the Selective Glucocorticoid Receptor Modulator Compound A on Bone Metabolism and Inflammation in Male Mice With Collagen-Induced Arthritis

et al. 2013

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Glucocorticoids (GCs) are potent drugs to treat rheumatoid arthritis but exert adverse skeletal effects. Compound A (CpdA) is a selective GC receptor modulator with an improved risk/benefit profile in mouse models of inflammation and bone loss. Here we tested whether CpdA also exerts bone-sparing effects under proinflammatory circumstances using the collagen-induced arthritis model, a murine model of rheumatoid arthritis. CpdA decreased disease activity, paw swelling, and the paw temperature by 43%, 12%, and 7%, respectively, but was less potent than dexamethasone (DEX), which reduced these parameters by 72%, 22%, and 10%, respectively. Moreover, T cells isolated from CpdA-and DEX-treated animals were less active based on proliferation rates after challenge with type II collagen and produced smaller amounts of interferon-␥ and TNF as compared with T cells from PBS-treated mice. Histological assessment of the joints confirmed the weaker potency of CpdA as compared with DEX in preventing infiltration of inflammatory cells, induction of osteoclastogenesis, and destruction of articular cartilage. Due to the lack of GC-susceptible arthritis models, we were not able to fully address the bone-sparing potential of CpdA in inflammatory conditions. Nevertheless, the bone formation marker procollagen type 1 N-terminal peptide, a surrogate marker for GC-mediated suppression of bone formation, was significantly decreased by DEX in arthritic mice but not by CpdA. Our data indicate that CpdA moderately suppresses inflammation, whereas the concurrent effects on bone remain unknown. In light of its narrow therapeutic range, CpdA may be more useful as a molecular tool for dissecting GC actions rather than a therapeutic agent. (Endocrinology 154: 3719 -3728, 2013)

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Section: Discussionmentioning

confidence: 96%

Effects of the Selective Glucocorticoid Receptor Modulator Compound A on Bone Metabolism and Inflammation in Male Mice With Collagen-Induced Arthritis

et al. 2013

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“…The method has been used for multiple purposes within medicine [1][2][3] and in the field of dentistry. [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] An inflammatory process is characterized by heat production and emission as one of the cardinal symptoms, which is why thermography may be used to evaluate inflammation.…”

Section: Introductionmentioning

confidence: 99%

Thermography as a quantitative imaging method for assessing postoperative inflammation

Christensen

Matzen²,

Væth³

et al. 2012

Dentomaxillofacial Radiology

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Objective: To assess differences in skin temperature between the operated and control side of the face after mandibular third molar surgery using thermography. Methods: 127 patients had 1 mandibular third molar removed. Before the surgery, standardized thermograms were taken of both sides of the patient's face using a Flir ThermaCam TM E320 (Precisions Teknik AB, Halmstad, Sweden). The imaging procedure was repeated 2 days and 7 days after surgery. A region of interest including the third molar region was marked on each image. The mean temperature within each region of interest was calculated. The difference between sides and over time were assessed using paired t-tests. Results: No significant difference was found between the operated side and the control side either before or 7 days after surgery (p . 0.3). The temperature of the operated side (mean: 32.39 u C, range: 28.9-35.3 u C) was higher than that of the control side (mean: 32.06 u C, range: 28.5-35.0 u C) 2 days after surgery [0.33 u C, 95% confidence interval (CI): 0.22-0.44 u C, p , 0.001]. No significant difference was found between the pre-operative and the 7-day postoperative temperature (p . 0.1). After 2 days, the operated side was not significantly different from the temperature pre-operatively (p 5 0.12), whereas the control side had a lower temperature (0.57 u C, 95% CI: 0.29-0.86 u C, p , 0.001). Conclusions: Thermography seems useful for quantitative assessment of inflammation between the intervention side and the control side after surgical removal of mandibular third molars. However, thermography cannot be used to assess absolute temperature changes due to normal variations in skin temperature over time.

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“…Rather than anatomical changes, in digital infrared imaging, diagnosis based on the principle of analyzing temperature variation associated with metabolic activity and vascular circulation changes in the affected area [4]. IR imaging is being widely used for diagnosis, to study the progress of treatment of many disorders mainly in the wide area of rheumatology [5], dermatology, orthopedics, and circulatory abnormalities [6]. Thermography was widely used in diagnosis, prognosis of several diseases, and to study progress of treatment with animal model.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Mammary Cancer in 7,12-Dimethylbenz(a)anthracene-Induced Wister Rats by Asymmetrical Temperature Distribution Analysis Using Thermography: A Comparison with Serum CEA Levels and Histopathology

Kirubha

Anburajan

Venkataraman

et al. 2012

Journal of Biomedicine and Biotechnology

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Animal surface temperature profile captured using infrared camera is helpful for the assessment of physiological responses associated with the regulation of body temperature. Diagnosing breast cancer in early stage itself has a greater effect on the prognosis. In this work, asymmetrical temperature distribution analysis of chemical carcinogen 7,12-dimethyl benz(a)anthracene-induced in the lower right flank region of Wistar rats (n = 6) was carried out to test the potential of thermography in diagnosing mammary cancer and tumor growth over a period of nine weeks in comparison with histopathology results as standard. Temperature difference between the tumor induced lower right and left side of flank region was significant (with P value <0.001), whereas in the abdomen and shoulder there was no significant difference in temperature between right and left sides. Percentage of asymmetrical temperature difference in the tumor induced lower flank region was 0.5 to 2%, whereas in the other regions it was <0.5%. Green pixel distribution in RGB color histogram was asymmetrical in the tumor induced lower flank region. Temperature reduction was observed in the tumor induced region after the seventh day of carcinogen induction. Asymmetrical thermogram analysis is the best method of diagnosing mammary cancer and for studying tumor development.

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Use of a portable thermal imaging unit as a rapid, quantitative method of evaluating inflammation and experimental arthritis

Cited by 37 publications

References 17 publications

Effects of the Selective Glucocorticoid Receptor Modulator Compound A on Bone Metabolism and Inflammation in Male Mice With Collagen-Induced Arthritis

Effects of the Selective Glucocorticoid Receptor Modulator Compound A on Bone Metabolism and Inflammation in Male Mice With Collagen-Induced Arthritis

Thermography as a quantitative imaging method for assessing postoperative inflammation

Evaluation of Mammary Cancer in 7,12-Dimethylbenz(a)anthracene-Induced Wister Rats by Asymmetrical Temperature Distribution Analysis Using Thermography: A Comparison with Serum CEA Levels and Histopathology

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