Use of a probiotic mixture containing Bifidobacterium animalis subsp. lactis BB12 and Enterococcus faecium L3 in atopic children

Pierro, Francesco Di; Basile, Isabella; Danza, Maria Luisa; Venturelli, Leo; Contini, Raffaele; Risso, P.; Colombo, Maria

doi:10.23736/s0026-4946.18.05203-9

Cited by 18 publications

(12 citation statements)

References 18 publications

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“…and Lactobacillus spp. , which are involved in the onset and cure of atopic dermatitis [ 1 , 3 , 4 , 5 , 6 ], increased with the administration of AP to TMA-treated mice. In addition, the amounts of B. fragilis , which corrects intestinal immunity and is involved in the allergy-like eczema [ 32 ], increased with the administration of AP ( Figure 6 ).…”

Section: Discussionmentioning

confidence: 99%

“…Recently, it has become clear that changes in the gut microbiota are associated with the onset and remission of atopic dermatitis [1,[3][4][5][6]. Therefore, we investigated the mechanism by which AP inhibited atopic dermatitis, focusing on the intestinal flora.…”

Section: The Phyla Firmicutes Bacteroidetes Proteobacteria and Actmentioning

confidence: 99%

“…Gut microbes, such as Bifidobacterium spp. and Lactobacillus spp., are called beneficial bacteria and are considered to be effective in the prevention and treatment of many diseases [1,[3][4][5][6]. Meanwhile, both Bacteroides fragilis and Clostridium coccoides are related to the onset and remission of inflammatory diseases [30][31][32].…”

Section: Bifidobacterium Spp Lactobacillus Spp Bacteroides Fragilmentioning

confidence: 99%

“…and fewer intestinal Bifidobacterium spp. in their feces than non-atopic dermatitis subjects [2] and that (2) the administration of probiotics improved atopic dermatitis [3][4][5][6]. Thus, drugs or foods that correct the gut microbiota may be useful for atopic dermatitis.…”

Section: Introductionmentioning

confidence: 99%

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Acacia Polyphenol Ameliorates Atopic Dermatitis in Trimellitic Anhydride-Induced Model Mice via Changes in the Gut Microbiota

Ikarashi

Fujitate

Togashi

et al. 2020

Foods

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We have previously shown that acacia polyphenol (AP), which was extracted from the bark of Acacia mearnsii De Wild, exerts antiobesity, antidiabetic, and antihypertensive effects. In this study, we examined the effect of AP on atopic dermatitis. Trimellitic anhydride (TMA) was applied to the ears of mice to create model mice with atopic dermatitis. The frequency of scratching behavior in the TMA-treated group was significantly higher than that in the control group, and the expression levels of inflammatory markers (tumor necrosis factor-α, interleukin-6, inducible nitric oxide synthase, and cyclooxygenase-2) in the skin also increased. In contrast, both the frequency of scratching behavior and the expression levels of skin inflammatory markers in the AP-treated group were significantly lower than those in the TMA-treated group. The abundances of beneficial bacteria, such as Bifidobacterium spp. and Lactobacillus spp., increased in the AP-treated group compared with the TMA-treated group. Furthermore, the abundances of Bacteroides fragilis and Clostridium coccoides in the gut, which are known for anti-inflammatory properties, increased significantly with AP administration. The present results revealed that AP inhibits TMA-induced atopic dermatitis-like symptoms. In addition, the results also suggested that this effect may be associated with the mechanism of gut microbiota improvement.

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Section: Discussionmentioning

confidence: 99%

Section: The Phyla Firmicutes Bacteroidetes Proteobacteria and Actmentioning

confidence: 99%

Section: Bifidobacterium Spp Lactobacillus Spp Bacteroides Fragilmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Acacia Polyphenol Ameliorates Atopic Dermatitis in Trimellitic Anhydride-Induced Model Mice via Changes in the Gut Microbiota

Ikarashi

Fujitate

Togashi

et al. 2020

Foods

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“…They concluded that the bifidobacteria mixture was able to significantly improve allergic rhinitis symptoms and quality of life. Di Pierro et al (85) applied a mixture of Bifidobacterium animalis subsp. lactis BB12 and Enterococcus faecium L3 administered 3 months before or during the development of atopy and concluded that when administered in the 3 months before the development of atopy (as a prophylactic), the probiotics reduced atopy symptoms.…”

Section: Therapeutic Applications Of Oral Probiotics In Chronic Lung Diseasesmentioning

confidence: 99%

Oral and nasal probiotic administration for the prevention and alleviation of allergic diseases, asthma and chronic obstructive pulmonary disease

et al. 2020

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Interaction between a healthy microbiome and the immune system leads to body homeostasis, as dysbiosis in microbiome content and loss of diversity may result in disease development. Due to the ability of probiotics to help and modify microbiome constitution, probiotics are now widely used for the prevention and treatment of different gastrointestinal, inflammatory, and, more recently, respiratory diseases. In this regard, chronic respiratory diseases including chronic obstructive pulmonary disease (COPD), asthma and allergic rhinitis are among the most common and complicated respiratory diseases with no specific treatment until now. Accordingly, many studies have evaluated the therapeutic efficacy of probiotic administration (mostly via the oral route and much lesser nasal route) on chronic respiratory diseases. We tried to summarise and evaluate these studies to give a perspective of probiotic therapy via both the oral and nasal routes for respiratory infections (in general) and chronic respiratory diseases (specifically). We finally concluded that probiotics might be useful for allergic diseases. For asthmatic patients, probiotics can modulate serum cytokines and IgE and decrease eosinophilia, but with no significant reduction in clinical symptoms. For COPD, only limited studies were found with uncertain clinical efficacy. For intranasal administration, although some studies propose more efficiency than the oral route, more clinical evaluations are warranted.

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A Comparative Study to Assess the Add on Effects of Probiotic in Allergic Rhinitis Patients in a Tertiary Care Hospital

Nagle

Kumar

kakde

2023

Indian J Otolaryngol Head Neck Surg

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Use of a probiotic mixture containing Bifidobacterium animalis subsp. lactis BB12 and Enterococcus faecium L3 in atopic children

Cited by 18 publications

References 18 publications

Acacia Polyphenol Ameliorates Atopic Dermatitis in Trimellitic Anhydride-Induced Model Mice via Changes in the Gut Microbiota

Acacia Polyphenol Ameliorates Atopic Dermatitis in Trimellitic Anhydride-Induced Model Mice via Changes in the Gut Microbiota

Oral and nasal probiotic administration for the prevention and alleviation of allergic diseases, asthma and chronic obstructive pulmonary disease

A Comparative Study to Assess the Add on Effects of Probiotic in Allergic Rhinitis Patients in a Tertiary Care Hospital

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