Use of a protein-based tissue adhesive as an aid for the surgical reconstruction of advanced and recurrent skin cancer tumors to the head and neck region: a technical report

Lustgarten, Leonardo; Abadi, Jose R.; Sancevic, R; Meneses, P; Morrel, Alberto Perez; Lugo, Joaquín

doi:10.1016/j.surneu.2006.09.035

Cited by 9 publications

(4 citation statements)

References 23 publications

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“…Soft tissue adhesives are an attractive alternative to sutures and staples, with a number of comparative advantages. Tissue adhesives are easy to apply, cause minimal trauma, they allow tissues to heal without needing to remove the adhesive at a later point, produce lower rates of infection [6,7] and less morbidity compared to staples and sutures, reduce operating time, and can improve cosmetic outcomes (i.e., less scaring) [1,8,9]. Many different adhesives have been explored for closing [10,11,12], or reattaching, injured soft tissues, including adhesives based on acrylate “superglue” [13], fibrin [14], polysaccharide [15,16], protein [1,17,18], or organic acid [19,20].…”

Section: Introductionmentioning

confidence: 99%

Adhesive Cements That Bond Soft Tissue Ex Vivo

et al. 2019

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The aim of the present study was to evaluate the soft tissue bond strength of a newly developed, monomeric, biomimetic, tissue adhesive called phosphoserine modified cement (PMC). Two types of PMCs were evaluated using lap shear strength (LSS) testing, on porcine skin: a calcium metasilicate (CS1), and alpha tricalcium phosphate (αTCP) PMC. CS1 PCM bonded strongly to skin, reaching a peak LSS of 84, 132, and 154 KPa after curing for 0.5, 1.5, and 4 h, respectively. Cyanoacrylate and fibrin glues reached an LSS of 207 kPa and 33 kPa, respectively. αTCP PMCs reached a final LSS of ≈110 kPa. In soft tissues, stronger bond strengths were obtained with αTCP PMCs containing large amounts of amino acid (70–90 mol%), in contrast to prior studies in calcified tissues (30–50 mol%). When αTCP particle size was reduced by wet milling, and for CS1 PMCs, the strongest bonding was obtained with mole ratios of 30–50% phosphoserine. While PM-CPCs behave like stiff ceramics after setting, they bond to soft tissues, and warrant further investigation as tissue adhesives, particularly at the interface between hard and soft tissues.

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Section: Introductionmentioning

confidence: 99%

Adhesive Cements That Bond Soft Tissue Ex Vivo

et al. 2019

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“…Currently, Bioglue TM (Cryolife, Inc., Kennesaw, GA, USA) is approved for use in the United States, which is a combination of bovine albumin with glutaraldehyde, and is used in otolaryngology, 20 urology, 21 and aneurological surgery. 22 However, the strong inflammatory response 23,24 and high toxicity 25 caused by the release of formaldehyde and glutaraldehyde have made their clinical applications limited to the repair of aortic dissections. 26 So far, none of these adhesives fulfills all a clinician's requirements, and therefore, a great deal of effort has been made to prepare new synthetic or semisynthetic ideal adhesives.…”

Section: Introductionmentioning

confidence: 99%

“…A combination of synthetic and biological components is represented by gelatin‐resorcinol‐formaldehyde‐glutaraldehyde glue (Medico Corp., Bucuresti, Romania). Currently, Bioglue™ (Cryolife, Inc., Kennesaw, GA, USA) is approved for use in the United States, which is a combination of bovine albumin with glutaraldehyde, and is used in otolaryngology, urology, and aneurological surgery . However, the strong inflammatory response and high toxicity caused by the release of formaldehyde and glutaraldehyde have made their clinical applications limited to the repair of aortic dissections .…”

Section: Introductionmentioning

confidence: 99%

Low cytotoxic tissue adhesive based on oxidized dextran and epsilon‐poly‐l‐lysine

Hyon

Nakajima²,

Sugai³

et al. 2013

J Biomedical Materials Res

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A novel adhesive hydrogel consisting of dextran and epsilon-poly(L-lysine) (dextran-PL) with multiple biomedical applications was developed. Periodate oxidation in aqueous media almost stoichiometrically introduces aldehyde groups in dextran molecules, and aldehyde dextran can react with the primary amino groups in epsilon-PL (ɛ-PL) at neutral pH to form a hydrogel. The gelation time of the hydrogel can be easily controlled by the extent of oxidation in dextran and of the acylation in ɛ-PL by anhydrides. The shear adhesion strength of dextran-PL was 10 times higher than that of fibrin glue, when wet collagen sheets were selected as test specimens. The cytotoxicity of aldehyde dextran and ɛ-PL were 1000 times lower than that of glutaraldehyde and poly(allylamine). The considerably low cytotoxicity of aldehyde dextran could be ascribed to its low reactivity with amine species when compared with glutaraldehyde. In contrast, a high reactivity of amino groups in ɛ-PL was observed when compared with glycine, L-lysine, and gelatin, which could be explained by their poor dissociation at neutral pH, thus leading to low cytotoxicity.

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“…The current clinic used tissue adhesives could be divided into three groups: (1) natural tissue adhesives, (2) synthetic and semisynthetic tissue adhesive, and (3) biomimetic tissue adhesives [2]. These tissue adhesives are extensively used different tissues, including skin [7][8][9], breast [10,11], cardiac [12][13][14], gastrointestinal [15], head and neck [16,17], hepatic [18,19], neurological [20], orthopedic [9,21], pediatric [8,22], thoracic [14,23], bone [24], dental [25] and vascular surgery [26,27]. For example, Dana et al reported a gelatin-methacryloyl based tissue adhesive (GelCORE) in the presence of a type 2 initiator Eosin Y (initiator), triethanolamine (TEA) (co-initiator), and N-vinylcaprolactam (VC) (co-monomer) for the sutureless repair of corneal injuries.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Tissue Adhesives for Clinical Medicine

Chen

2020

Polymers

107

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Tissue adhesives have attracted more attention to the applications of non-invasive wound closure. The purpose of this review article is to summarize the recent progress of developing tissue adhesives, which may inspire researchers to develop more outstanding tissue adhesives. It begins with a brief introduction to the emerging potential use of tissue adhesives in the clinic. Next, several critical mechanisms for adhesion are discussed, including van der Waals forces, capillary forces, hydrogen bonding, static electric forces, and chemical bonds. This article further details the measurement methods of adhesion and highlights the different types of adhesive, including natural or biological, synthetic and semisynthetic, and biomimetic adhesives. Finally, this review article concludes with remarks on the challenges and future directions for design, fabrication, and application of tissue adhesives in the clinic. This review article has promising potential to provide novel creative design principles for the generation of future tissue adhesives.

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Use of a protein-based tissue adhesive as an aid for the surgical reconstruction of advanced and recurrent skin cancer tumors to the head and neck region: a technical report

Cited by 9 publications

References 23 publications

Adhesive Cements That Bond Soft Tissue Ex Vivo

Adhesive Cements That Bond Soft Tissue Ex Vivo

Low cytotoxic tissue adhesive based on oxidized dextran and epsilon‐poly‐l‐lysine

Recent Advances in Tissue Adhesives for Clinical Medicine

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