Abstract— A clinical and radiographic study was undertaken on 1,600 periapical lesions from 1,133 patients referred for extractions or apicoectomies. The clinical findings as well as the radiographic size (diameter) of the lesions were recorded. When this diameter measured less than 5 mm, the pathologic tissue was left in the bone after extraction, whereas in cases where the lesions were 5 mm or more, an excochleation was done and the specimens subjected to a routine histologic examination. In the group consisting of 753 controlled periapical lesions less than 5 mm in diameter all cases healed uneventfully within two years. The distribution of all periapical lesions according to regions was found to be in good correlation with caries frequency. Likewise the distribution within the dental arch of histologically verified granulomas and cysts was compared with earlier reports. A statistically significant higher proportion of cysts was found in the premolar than in the molar region (0.025 > P > 0.02), whereas the opposite was true regarding granulomas. The preoperative radiographic diagnosis showed only poor correlation with the histologic diagnosis. Fistulae occurred more often in connection with granulomas than with cysts (statistically significant, 0.025 > P > 0.01).