Use of a stopped-flow/T-format spectrofluorimeter for simultaneous kinetic analyses

Gala, B.; Gómez‐Hens, A.; Pérez‐Bendito, Dolores

doi:10.1016/0003-2670(95)00153-q

Cited by 12 publications

(3 citation statements)

References 8 publications

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“…22 The simultaneous kinetic determination of phenothiazine drugs was also reported. 23 Fasanmade reported a multivariate calibration method based on principal component regression (PCR) for the simultaneous ultraviolet (UV) determination of an oxidation product of CPH sulphoxide. 24 Shamsipur et al tested partial least-squares (PLS) regression, singular value decomposition-based PLS, and an artificial neural network (ANN) as calibration procedures for the simultaneous determination of PH, CPH, and PP by both conventional and derivative spectrophotometry.…”

Section: Introductionmentioning

confidence: 99%

Individual and simultaneous determinations of phenothiazine drugs using PCR, PLS and (OSC)-PLS multivariate calibration methods

Karimi

Mazloum-Ardakani

Behjatmanesh–Ardakani

et al. 2008

J Serb Chem Soc

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Individual and simultaneous determinations of some phenothiazine drugs are described. The individual determination method is based on the reaction of chlorpromazine hydrochloride (CPH), promethazine hydrochloride (PH), trifluoperazine hydrochloride (TFPH), trimipramine maleate (TPM) and thioridazine hydrochloride (TRDH) with complex of [Fe(Bpy) 3 ] 3+ . In the presence of phenothiazine derivatives, [Fe(Bpy) 3 ] 3+ is reduced easily to the coloured complex [Fe(Bpy) 3 ] 2+ , which shows an absorption maximum at 525 nm. The individual method is highly sensitive and suitable for 0.3-190 µg ml -1 concentrations, with detection limits in the range 0.18-2.46 µg ml -1 . Simultaneous kinetic-spectrophotometric determination of ternary mixture of CPH, PH and TPM using principal component regression (PCR), partial least squares (PLS) and orthogonal signal correction (OSC)-PLS multivariate calibration methods is also described. The simultaneous methods are based on the difference observed in the reduction rate of the [Fe(Bpy) 3 ] 3+ complex with CPH, PH and TPM in acidic media. The results showed that the simultaneous determination of CPH, PH and TPM can be performed in the concentration ranges of 0.5-120.0, 0.3-80.0 and 5.0-100.0 µg ml -1 , respectively, for three methods (PCR, PLS and OSC-PLS). The root mean square errors of prediction (RMSEP) of CPH, PH and TPM were 0.346, 0.663 and 0.820 (for PCR) 0.317, 0.659 and 0.830 (for PLS) and 0.087, 0.124 and 0.085 (for OSC-PLS), respectively. The proposed methods were successfully applied to the individual and simultaneous determination of phenothiazine derivatives in pharmaceutical preparations, the results of which compared well with those obtained by the official method, and several synthetic (spiked) samples, whereby satisfactory results were obtained.

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Section: Introductionmentioning

confidence: 99%

Individual and simultaneous determinations of phenothiazine drugs using PCR, PLS and (OSC)-PLS multivariate calibration methods

Karimi

Mazloum-Ardakani

Behjatmanesh–Ardakani

et al. 2008

J Serb Chem Soc

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“…Different analytical methods have been published for their determination. The most commonly used methods are spectrophotometric [4][5][6] , spectrofluorimetric [7][8][9] , chromatographic [10][11][12] and electrochemical methods [13][14][15]. …”

Section: Reagents Chemicals and Standard Solutionsmentioning

confidence: 99%

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Taha¹,

Hassan²,

Aal³

et al. 2008

ScienceAsia

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A simple, sensitive and validated kinetic spectrophotometric method for the determination of certain mucolytic drugs namely acetylcysteine (Ac) and carbocisteine (Cc) is described. This method is based on the kinetic investigation of the reaction between the two cited drugs and 4-chloro-7-nitrobenzo-2-oxa 1, 3 -diazole (NBD-Cl) in an alkaline medium. Spectrophotometric measurements were achieved by recording the absorbance at 424 nm at ambient temperature (25 0 C ±5) for a fixed time of 30 minutes for Ac, and at 468 nm for a fixed time of 15 minutes at 70 0 C for Cc. All variables affecting the development of the reaction were investigated and optimized. The method was found to be linear over the range of 2-22 μg ml -1 for Ac, and 5-35 μg ml -1 for Cc with mean percentage recoveries of 99.59 ± 0 .41 and 99.50 ± 0.65, respectively. Molar absorpitivity and sensitivity index were determined and found to be (1.094x10 3 and 1.49x10 -2 , respectively, for Ac, and 2.547x10 3 and 3.05x10 -2 , respectively for Cc. The validity of the method was assessed according to USP guidelines. The proposed method was successfully applied for the determination of the two cited drugs in bulk powder, in pharmaceutical formulations as well as in the presence of their related substances. The results obtained were found to agree statistically with those obtained by official and reported methods. In this study the determination of the two drugs by the fixed time method proved to be more applicable than the fixed absorbance and rate constant methods.

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“…The determination of antihistamines in pharmaceutical preparations for its quality control has been performed using several analytical techniques, such as volumetric analysis [2,3], voltametria [4], atomic absorption [5], fluorimetry [6,7], spectrophotometry [8][9][10][11][12], gas chromatography [13] liquid chromatography [14][15][16][17], capillary electrophoresis [18] and micellar electrokinetic chromatography [19,20].…”

Section: Introductionmentioning

confidence: 99%

Analysis of pharmaceutical preparations containing antihistamine drugs by micellar liquid chromatography

Martínez-Algaba

Bermúdez-Saldaña

Villanueva-Camañas

et al. 2006

Journal of Pharmaceutical and Biomedical Analysis

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Use of a stopped-flow/T-format spectrofluorimeter for simultaneous kinetic analyses

Cited by 12 publications

References 8 publications

Individual and simultaneous determinations of phenothiazine drugs using PCR, PLS and (OSC)-PLS multivariate calibration methods

Individual and simultaneous determinations of phenothiazine drugs using PCR, PLS and (OSC)-PLS multivariate calibration methods

Untitled

Analysis of pharmaceutical preparations containing antihistamine drugs by micellar liquid chromatography

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