Individual and simultaneous determinations of phenothiazine drugs using PCR, PLS and (OSC)-PLS multivariate calibration methods

Abstract

Individual and simultaneous determinations of some phenothiazine drugs are described. The individual determination method is based on the reaction of chlorpromazine hydrochloride (CPH), promethazine hydrochloride (PH), trifluoperazine hydrochloride (TFPH), trimipramine maleate (TPM) and thioridazine hydrochloride (TRDH) with complex of [Fe(Bpy) 3 ] 3+ . In the presence of phenothiazine derivatives, [Fe(Bpy) 3 ] 3+ is reduced easily to the coloured complex [Fe(Bpy) 3 ] 2+ , which shows an absorption maximum at 525 nm. The individual method is highly sensitive and suitable for 0.3-190 µg ml -1 concentrations, with detection limits in the range 0.18-2.46 µg ml -1 . Simultaneous kinetic-spectrophotometric determination of ternary mixture of CPH, PH and TPM using principal component regression (PCR), partial least squares (PLS) and orthogonal signal correction (OSC)-PLS multivariate calibration methods is also described. The simultaneous methods are based on the difference observed in the reduction rate of the [Fe(Bpy) 3 ] 3+ complex with CPH, PH and TPM in acidic media. The results showed that the simultaneous determination of CPH, PH and TPM can be performed in the concentration ranges of 0.5-120.0, 0.3-80.0 and 5.0-100.0 µg ml -1 , respectively, for three methods (PCR, PLS and OSC-PLS). The root mean square errors of prediction (RMSEP) of CPH, PH and TPM were 0.346, 0.663 and 0.820 (for PCR) 0.317, 0.659 and 0.830 (for PLS) and 0.087, 0.124 and 0.085 (for OSC-PLS), respectively. The proposed methods were successfully applied to the individual and simultaneous determination of phenothiazine derivatives in pharmaceutical preparations, the results of which compared well with those obtained by the official method, and several synthetic (spiked) samples, whereby satisfactory results were obtained.

Mutual Determination of Trifluoperazine Hydrochloride and Vanadium (V) Ions in Real Matrices by Visible Spectrophotometry After Cloud Point Extraction

“…This because of the ratio (MSreg/MSerror) for 1 and 7 dof, and 1 and 8 dof, larger than critical value(F 1,7 = 5.59 and F 1,8 = 5.32 at α=0.05), indicating that the predication based on the regression line is satisfactory as listed in Table 3. Concerning the limit of detection for the drug TFPH, our finding was in harmony with that obtained by Karimi et al [20] using indirect spectrophotometric method and principal component regression (PCR), partial least squares (PLS) and orthogonal signal correction (OSC)-PLS multivariate calibration methods and was 8-fold better better than that obtained by Navyasri et al [12] and 2-fold better than that obtained by Pattanayak and Ash Rani [11] whom using RP-HPLC method. However, it was worse than that obtained by Sharma etal [6] Patel and Patel [7], Parvataneni and Nagarjuna [13] using the developed RP-HPLC, and Waleed [4] using indirect flame AAS.…”

“…Vanadium (V) Ions in Real Matrices by Visible Spectrophotometry After Cloud Point Extraction TFFH is subjected to many research works, either for the development of the methods of its determination in pure form and pharmaceuticals or as chromogenic reagent for estimation of various target analytes. The literature survey reveals that a number of analytical methods for detection of this drug individually or in combination with other drugs have been used including, indirect atomic absorption spectrometry [4], potentiometry [5], reverse phase high performance liquid chromatography (RP-HPLC) [6][7][8][9][10][11][12][13], solid-phase extraction-high performance liquid chromatography (SPE-HPLC) [14], liquid chromatography -mass spectrometry / mass spectrometry (LC-MS/MS) [15] densitometry [16] and spectrophotometry [17][18][19][20]. Also, this drug was proposed as a chelating agent for the determination of some metal ions like Cr +6 [21], Tl 3+ [22], Fe 3+ [23] ions.…”

A perspective on the growth of chemometrics in Iran: a glance into activities between 2005 and 2012

“…As mentioned, 373 papers were published in the period of 2005–2012. Some of these papers that include different area of applications and/or different journals are cited in this paper . These articles cover applications of PLS, PCR, orthogonal signal correction‐PLS, genetic algorithm‐PLS (GA‐PLS), multiple linear regression, and a few MVC‐ANN for simultaneous analysis using first‐order data.…”

Application of H-Point Standard Addition Method and Multivariate Calibration Methods to the Simultaneous Kinetic-Potentiometric Determination of Cerium(IV) and Dichoromate

“…These methods are based on a first calibration step in which a mathematical model is built using a chemical data set (e.g., potential values) and a concentration matrix data set [30][31][32][33][34]. The calibration is followed by a prediction set in which this model is used to estimate unknown concentrations of a mixture from kinetic profile.…”

“…The theories and applications of chemometrics methods such as PCR and PLS, to the analysis of multi-component mixtures, have been discussed by several workers [31][32][33][34][35]. PCR and PLS modeling are powerful multivariate statistical tools, which are successfully applied to the quantitative analysis of spectrochemical and electrochemical data [33][34][35][36]. The first step in the simultaneous determination of the species by PCR and PLS methodologies involves the construction of calibration matrix for the binary mixture of Ce 4+ and Cr 2 O 7 2-.…”