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A green method was established for the mutual determination of the drug trifluoperazine hydrochloride (TFPH) and vanadium (V) in real samples by coupling the cloud point extraction with UV-Vis spectrophotometry. The method was based on the formation of the colored V (V)-TFPH complex in acidic medium followed the extraction of the complex by using the surfactant Triton X-114 as an extracting medium. The surfactant-rich phase extracted was dissolved in a small volume of solvent and both the drug TFPH and V (V) ions determined by spectrophotometry at maximum absorption wavelength of 476 nm. Most parameters which impact on the extraction efficiency and detection for both target analytes were optimized. Under the optimum conditions established, the preconcentration factor was found to be of 50 fold making Beer's law obeyed in the concentration range of 2-80 µg mL -1 (r = 0.9999) for the determination of TFPH and 0.5-10 µg mL -1 (r = 0.9995) for vanadium (V), giving the detection limits of 1.21 and 0.113 µg mL -1 respectively. The mean recovery percentage of 98.94±2.19 % (in blood serum) and 99.43±1.40 (in tap water); the precision (RSD %) ranged between 0.48-3.40 % and 0.45-1.49 were obtained for TFPH and V (V) ions respectively. The proposed method was employed for the determination of TFPH in pharmaceuticals and the spiked serum samples, while a V (V) ion was determined in black pepper samples.

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Two simple eco-friendly methods are described for nano-determination of carbendazim (MBC) pesticide in real samples. These methods are based on oxidation of MBC pesticide with Fe (III) ions in acidic medium. The formed Fe(II) ions reacts with potassium ferricyanide to form blue colored product (method A) which can easily be extracted into nonionic surfactant solution of Triton X-114 at cloud point temperature (CPT) of 55°C and MBC determined spectrophotometrically at absorption maximum of 685 nm with apparent molar absorptivity of 2.07x10 4 L mol-1 cm-1. The Method B is based on the reaction of the formed Fe (II) with 2, 2'-bipyridyl to form a stable orange colored complex which can also be extracted by Triton X-114 at the same CPT and MBC determined spectrophotometrically at absorption maximum of 521 nm with apparent molar absorptivity of 1.83x10 4 L mol-1 cm-1. Optimization of the experimental parameters was described and interferences study also examined. Under the optimum conditions established, the calibration graphs for MBC were linear in the range of 0.5-13 and 1-20 ng mL-1 , giving the detection limits of 0.46 and 0.49 ng mL-1 with enrichment factors of 85.7 and 38.9 fold for method A and B respectively. The average percent recoveries in the real spiked samples were (97.86±1.06%) and (98.66±0.93%), giving a precision in terms of %RSD in the range of 1.25-2.97% and 0.37-1.42% for method A and B respectively. The proposed methods were applied to the determination of MBC in vegetables, orange, and water samples.