Use of a urease inhibitor to mitigate ammonia emissions from urine patches

Rodríguez, María Margarita; Saggar, Surinder; Berben, Peter H.; Palmada, Thilak; López‐Villalobos, N.; Pal, Pranoy

doi:10.1080/09593330.2019.1620345

Cited by 18 publications

(12 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The pH values of S WD and S HK were 7.9 and 5.7, respectively. The alkaline condition (high pH) of S WD is likely to lead more conversion of NH 4 + –N in three fertilizers to NH 3 , followed by its volatilization loss, , and a low pH of S HK favors HONO release from soil . In addition to HONO, postfertilization NO emissions also increased for both S WD and S HK at a low SWC, while the effect of fertilization on NO emission at a high SWC is not obvious (Figure S2).…”

Section: Resultsmentioning

confidence: 99%

Agricultural Fertilization Aggravates Air Pollution by Stimulating Soil Nitrous Acid Emissions at High Soil Moisture

Wang

et al. 2021

Environ. Sci. Technol.

View full text Add to dashboard Cite

Nitrogen lost from fertilized soil is a potentially large source of atmospheric nitrous acid (HONO), a major precursor of the hydroxyl radical. Yet, the impacts of fertilizer types and other influencing factors on HONO emissions are unknown. As a result, the current state-of-the-art models lack an appropriate parameterization scheme to quantify the HONO impact on air quality after fertilization. Here, we report laboratory measurements of high HONO emissions from soils at a 75−95% water-holding capacity after applying three common fertilizers, which contrasts with previous lower predictions at high soil moisture. Urea use leads to the largest release of HONO compared to the other two commonly used fertilizers (ammonium bicarbonate and ammonium nitrate). The significant promotion effect of fertilization lasted up to 1 week. Implementation of the lab-derived parametrization in a chemistry transport model (CMAQ) significantly improved postfertilization HONO predictions at a rural site in the agriculture-intensive North China Plain and increased the regionally averaged daytime OH, O 3 , and daily fine particulate nitrate concentrations by 41, 8, and 47%, respectively. The results of our study underscore the necessity to include this large postfertilization HONO source in modeling air quality and atmospheric chemistry. Fertilizer structure adjustments may reduce HONO emissions and improve the air quality in polluted regions with intense agriculture.

show abstract

Section: Resultsmentioning

confidence: 99%

Agricultural Fertilization Aggravates Air Pollution by Stimulating Soil Nitrous Acid Emissions at High Soil Moisture

Wang

et al. 2021

Environ. Sci. Technol.

View full text Add to dashboard Cite

show abstract

“…For instance, the use of NBPT coated urea compared to uncoated-urea reduced NH3 emission by 42% for sunflower in Spain [78]; from 9.5% to 1.0% of applied N for winter wheat in Australia [79], and finally in the UK, for multiple grassland and winter cereal species [80]. In New Zealand, the volatilization of NH 3 in grazing pastures was reduced through the application of NBPT (18%-28%) [81]. Moreover, the application of nitrification inhibitors such as DCD and DMPP in conjunction with urea significantly reduced N 2 O emission from agricultural soils of Louisiana, USA by more than 76% and 67%, respectively [82].…”

Section: Enhanced Efficiency Of Fertilizer Materialsmentioning

confidence: 99%

Nitrogen Losses and Potential Mitigation Strategies for a Sustainable Agroecosystem

et al. 2021

View full text Add to dashboard Cite

Nitrogen (N) in the agricultural production system influences many aspects of agroecosystems and several critical ecosystem services widely depend on the N availability in the soil. Cumulative changes in regional ecosystem services may lead to global environmental changes. Thus, the soil N status in agriculture is of critical importance to strategize its most efficient use. Nitrogen is also one of the most susceptible macronutrients to environmental loss, such as ammonia volatilization (NH3), nitrous oxide (N2O) emissions, nitrate leaching (NO3), etc. Any form of N losses from agricultural systems can be major limitations for crop production, soil sustainability, and environmental safeguard. There is a need to focus on mitigation strategies to minimize global N pollution and implement agricultural management practices that encourage regenerative and sustainable agriculture. In this review, we identified the avenues of N loss into the environment caused by current agronomic practices and discussed the potential practices that can be adapted to prevent this N loss in production agriculture. This review also explored the N status in agriculture during the COVID-19 pandemic and the existing knowledge gaps and questions that need to be addressed.

show abstract

“…9 In the field of medicine, certain bacterial ureases served as vital toxic factors, which were closely associated with the development of renal calculi, nephropyelitis, digestive ulcer, and additional complications. 10,11 Over the past few decades, a large amount of urease inhibitors were widely explored, such as hydroxamates, boric and borous acids, heavy metallic cations, phosphoroamides, and polyphenols. 12,13 Nevertheless, most of the inhibitors were unsuitable for the development of new drugs due to the strong toxicity or instability.…”

Section: Introductionmentioning

confidence: 99%

“…In the agricultural industry, strong activity of urease contributes to superfluous ammonia release into the ambient air during urea fertilization, thereby resulting in serious problems in the environment and economics . In the field of medicine, certain bacterial ureases served as vital toxic factors, which were closely associated with the development of renal calculi, nephropyelitis, digestive ulcer, and additional complications. , Over the past few decades, a large amount of urease inhibitors were widely explored, such as hydroxamates, boric and borous acids, heavy metallic cations, phosphoroamides, and polyphenols. , Nevertheless, most of the inhibitors were unsuitable for the development of new drugs due to the strong toxicity or instability . Some reports also revealed serious side effects, including teratogenicity and psycho-neurological and musculo-integumentary syndrome. , Therefore, the priority of current studies concentrated on exploiting natural-derived urease inhibitors with high activity, low toxicity, and favorable stability.…”

Section: Introductionmentioning

confidence: 99%

Inactivation of Jack Bean Urease by Nitidine Chloride from Zanthoxylum nitidum: Elucidation of Inhibitory Efficacy, Kinetics and Mechanism

Lü

Tan

et al. 2021

J. Agric. Food Chem.

View full text Add to dashboard Cite

Urease is a metalloenzyme that catalyzes the hydrolysis of urea into ammonia and carbon dioxide, which has a negative impact on human health and agriculture. In this study, the inactivation of jack bean urease by nitidine chloride (NC) was investigated to elucidate the inhibitory effect, kinetics, and underlying mechanism of action. The results showed that NC acted as a concentration- and time-dependent inhibitor with an IC50 value of 33.2 ± 4.8 μM and exhibited a similar inhibitory effect to acetohydroxamic acid (IC50 = 31.7 ± 5.8 μM). Further kinetic analysis demonstrated that NC was a slow-binding and non-competitive inhibitor for urease. Thiol-blocking reagents (dithiothreitol, glutathione, and l-cysteine) significantly retarded urease inactivation, while Ni2+ competitive inhibitors (boric acid and sodium fluoride) synergetically suppressed urease with NC, suggesting that the active site sulfhydryl groups were possibly obligatory for NC blocking urease. Molecular docking simulation further argued its inhibition mechanism. Additionally, NC-induced deactivation of urease was verified to be reversible since the inactivated enzyme could be reactivated by glutathione. Taking together, NC was a non-competitive inhibitor targeting the thiol group at the active site of urease with characteristics of concentration dependence, reversibility, and slow binding, serving as a promising novel urease suppressant.

show abstract

Use of a urease inhibitor to mitigate ammonia emissions from urine patches

Cited by 18 publications

References 43 publications

Agricultural Fertilization Aggravates Air Pollution by Stimulating Soil Nitrous Acid Emissions at High Soil Moisture

Agricultural Fertilization Aggravates Air Pollution by Stimulating Soil Nitrous Acid Emissions at High Soil Moisture

Nitrogen Losses and Potential Mitigation Strategies for a Sustainable Agroecosystem

Inactivation of Jack Bean Urease by Nitidine Chloride from Zanthoxylum nitidum: Elucidation of Inhibitory Efficacy, Kinetics and Mechanism

Contact Info

Product

Resources

About