Use of Acetaminophen (Paracetamol) During Pregnancy and the Risk of Autism Spectrum Disorder in the Offspring

Andrade, Chittaranjan

doi:10.4088/jcp.16f10637

Cited by 24 publications

(18 citation statements)

References 14 publications

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“…1 It has been previously reported that between 40% and 65% of pregnant women use acetaminophen, [1][2][3][4][5][6][7] with estimates of 3%-20% of women reporting use in all three trimesters. 3,8 An emerging set of studies have signalled modest, yet concerning associations between acetaminophen and select pregnancy and childhood adverse outcomes, including preeclampsia, 9,10 preterm birth, 9 asthma (review and meta-analysis 11 ), and neurodevelopmental disorders [3][4][5][6][7][8][12][13][14] (review and meta-analysis 15 ). However, interpretation of these findings as causally related to prenatal acetaminophen exposure has been problematic.…”

Section: Backg Rou N Dmentioning

confidence: 99%

“…206 22389 (26) 198 (23) 50 (26) 35 (26) 48 ( Pregnancy was unplanned 214 (23) 359 (24) 206 (24) 43 2332 (23) 40 (29) 38 ( 133 (14) 301 (20) 155 (18) 40 (21) 33 2431 (23) 42 (24) Previous spontaneous abortion 232 (25) 376 (25) 205 (24) 55 (29) 40 (29) 37 (27) 39 ( 15 89 716 1214 (8) Pregnancy 14 1011 (6) Antidepressant use in pregnancy 25 (3) 109 753 (6) 17 97 523 179 (5) Medical co-morbidities c Depression 115 (12) 297 (20) 153 (18) 35 1832 (23) 49 3628 (16) Anxiety 59 (6) 177 (12) 86 (10) 25 1319 (14) ...…”

Section: Characteristics Of Women By Duration Of Usementioning

confidence: 99%

See 1 more Smart Citation

Acetaminophen use in pregnancy: Examining prevalence, timing, and indication of use in a prospective birth cohort

Bandoli

Palmsten

Chambers

2019

Paediatric Perinatal Epid

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Background: Previous studies of prenatal acetaminophen use have not addressed what indications and maternal co-factors describe acetaminophen use.Objective: The objective of this study was to describe these parameters in a wellcharacterised, prospective birth cohort.Methods: Data were drawn from the MotherToBaby study of pregnant women enrolled from 2004 to 2018. Daily acetaminophen diaries were calculated for all exposed women with complete dose and duration information. Descriptive statistics were used to assess maternal characteristics associated with acetaminophen use.Prevalence by 2-year interval was described, and linear regression was used to test for trend. Indication of use and dose per indication were summarised.Results: Of 2441 subjects, 1515 (62%) reported use of acetaminophen. Over the 15-year period, there was a decline in use of 2.5% for each 2-year period (test for trend = 0.001) with 58% reporting acetaminophen use in 2017-2018. Among women with acetaminophen use in pregnancy (n = 1515), 58% reported <10 days of use, 13% reported 10-19 days of use, 9% reported 20-44 days of use, and 9% reported 45 or more days of use. Twelve per cent had undefined duration of use. Increasing duration of exposure was associated with tobacco use, obesity, self-reported depression or anxiety, and antidepressant use. The most frequently reported indication was headache, however, indication varied by duration of use, with more women reporting use for sleep or pain/injury in the categories with the longest duration of use. Median dose per exposed day was highest among those reporting use for sleep, and higher doses were more frequently reported for arthritis, injury, and pain. Conclusion:Acetaminophen is used by the majority of pregnant women, and some continue to use for many weeks in pregnancy. Given the heterogeneity in duration of use, indication, and dose, studies that estimate the risk of adverse outcomes associated with acetaminophen must carefully consider these factors. K E Y W O R D Sacetaminophen, indications for use, pregnancy, prevalence

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Section: Backg Rou N Dmentioning

confidence: 99%

Section: Characteristics Of Women By Duration Of Usementioning

confidence: 99%

Acetaminophen use in pregnancy: Examining prevalence, timing, and indication of use in a prospective birth cohort

Bandoli

Palmsten

Chambers

2019

Paediatric Perinatal Epid

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“…2,[5][6][7][8][9] Possible adverse consequences include neurodevelopmental impairments, 4 autism spectrum disorder (ASD), 5 and ADHD. Mechanisms and possible association with ASD were examined in an earlier article in this column 10 and will not be repeated in this article.…”

Section: Acetaminophen In Pregnancymentioning

confidence: 99%

“…The studies of Brandlistuen et al 4 and Liew et al 5 were examined in greater detail in the previous article in this column. 10 …”

Section: Prenatal Acetaminophen Exposure Attention and Hyperactivitymentioning

confidence: 99%

Use of Acetaminophen (Paracetamol) During Pregnancy and the Risk of Attention-Deficit/Hyperactivity Disorder in the Offspring

Andrade

2016

J. Clin. Psychiatry

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“…APAP may influence the oxidative stress via disturbing inflammatory and immunological mechanisms. This effect is hypothesized to have the potential to cause an evil role in pregnancy outcome [5,6].…”

Section: Introductionmentioning

confidence: 99%

Monster Phase of Acetaminophen Use in Pregnancy: Current Vision of an Old Drug

S.s.¹,

Swaminathan²,

Sambathkumar³

2016

Int J Pharm Pharm Sci

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In various countries, Acetaminophen [APAP] is the frequently used painkiller found in hundreds of medications during pregnancy. It has been broadly used for eras and health care professionals prefer acetaminophen as a choice during pregnancy for relieving pain and fever. Current research reports bothersome inclinations in the rate of acetaminophen exposure and related pregnancy outcome. The exposure of pregnant women to acetaminophen is of great concern. Existing literature evidence shows that acetaminophen exposure during pregnancy may leads to preterm birth, attention deficit hyperactivity disorder (ADHD), autism, male infertility, asthma in pediatrics. Therefore, the prophylactic anticipation of acetaminophen exposure can be a far-sighted approach in order to safeguard humans and wildlife from enduring dangerous effects. This article reviews the epidemiological findings and aims to shed awareness into the second generation outcome of an old drug in pregnant women.

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Use of Acetaminophen (Paracetamol) During Pregnancy and the Risk of Autism Spectrum Disorder in the Offspring

Cited by 24 publications

References 14 publications

Acetaminophen use in pregnancy: Examining prevalence, timing, and indication of use in a prospective birth cohort

Acetaminophen use in pregnancy: Examining prevalence, timing, and indication of use in a prospective birth cohort

Use of Acetaminophen (Paracetamol) During Pregnancy and the Risk of Attention-Deficit/Hyperactivity Disorder in the Offspring

Monster Phase of Acetaminophen Use in Pregnancy: Current Vision of an Old Drug

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