Use of amiodarone during pregnancy

Robson, D. J.; Raj, M V; Storey, G. C. A.; Holt, David W.

doi:10.1136/pgmj.61.711.75

Cited by 28 publications

(10 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This probably explains the apparent paradox of an euthyroid mother giving birth to a severely hypothyroid child. Amiodarone crosses the placental barrier (1,14) and is also found in breast milk (1,11,13,14). In up to 20% of patients treated with Amiodarone thyroid function is altered (4,8,9).…”

Section: Discussionmentioning

confidence: 99%

“…The side effects on thyroid function in adults and children are well documented (2)(3)(4)(5)(6)(7)(8)(9)(10). No adverse effects on fetal thyroid function have been observed with maternal ingestion of Amiodarone during early or late pregnancy (1,11,12,13,14). We present a case of neonatal hypothyroidism with goiter, associated with Amiodarone ingestion during pregnancy.…”

mentioning

confidence: 97%

See 1 more Smart Citation

Congenital Hypothyroid Goiter and Amiodarone

et al. 1988

View full text Add to dashboard Cite

Amiodarone is an anti-arrhythmic drug with a content of 39% Iodine. No adverse effects on fetal thyroid function have previously been observed with maternal ingestion of Amiodarone during pregnancy. A case of severe congenital hypothyroidism with goiter, associated with maternal ingestion of 200 mg Amiodarone daily from the 13th week of pregnancy, is described here. No other environmental causes of goiter, nor a congenital organic thyroid disorder could be demonstrated.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 97%

Congenital Hypothyroid Goiter and Amiodarone

et al. 1988

View full text Add to dashboard Cite

show abstract

“…This variability may explain the time of myocardial sampling after amiodarone injection, as well as differences in the patients´ body weights, in the variable regional coronary blood flow from patient to patient at the time of sampling, in the extent of myocardial fibrosis, and in the variations in myocardial concentration dependent on the specific site and depth of biopsy 12 . There was also demonstrated placental transfer of amiodarone and DEA in humans 13 . It is surprising that even at steady state, plasma amiodarone concentrations can be expected to fall by 25% within a few days of the cessation of therapy and 50% in 36 days.…”

Section: Pharmacokineticsmentioning

confidence: 86%

Therapeutic monitoring of amiodarone: pharmacokinetics and evaluation of the relationship between effect and dose/concentration

Vyskocilova¹,

Grundmann²,

Kacířová³

2017

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

View full text Add to dashboard Cite

Amiodarone is the most effective agent in the therapy of arrhythmias. However, the clinical effect of acute and chronic treatment is unclear and there are differences irrespective of comparable plasma/myocardial amiodarone and its metabolite desethylamiodarone concentations as well. Its unusual pharmacokinetics results in interindividual variation in plasma levels. The association between amiodarone and desethylamiodarone plasma levels and clinical efficacy is difficult to evaluate. This review was carried out to assess whether there is any objective correlation between amiodarone and desethylamiodarone plasma levels and the clinical effect. We summarized the results of relevant studies and clarified the relationship between plasma levels and effect vis á vis the pharmacokinetics and pharmacogenetics of this drug. Certain correlation was seen with oral amiodarone therapy, in others, plasma amiodarone levels were unrelated to therapeutic response and showed no correlation with changes in electrocardiogram or electrophysiological parametres. Several studies show that plasma concentration ranging between 0.5 and 2.5 mg/L appears to be the most effective, others demonstrate no difference between responders and non-responders. One way of interpreting plasma levels is to establish an individual patient´s effective concentration. Therapeutic drug monitoring can contribute to determining optimal concentration.

show abstract

“…Occasionally, amiodarone has been given to pregnant women for treatment of resistant tachycardia, and 8 isolated cases were reported in the literature (3,(8)(9)(10)(11)(12)(13)(14). In 6 cases a normal child resulted from the pregnancy, whereas transient hypothyroidism was detected in 2 cases.…”

Section: Discussionmentioning

confidence: 99%

Outcome of Thyroid Function in Newborns from Mothers Treated with Amiodarone

Matsumura¹,

Born²,

Kunii³

et al. 1992

Thyroid

View full text Add to dashboard Cite

Amiodarone, a drug extensively used as an antiarrhythmic agent, contains 37% iodine and causes several thyroid abnormalities. The transplacental passage of amiodarone occurs with chronic therapy; we describe in this report the outcome of 9 pregnant women who used amiodarone (200 mg/day) for treatment of resistant tachycardia and the follow-up of their newborns. All women were clinically euthyroid at the 3rd trimester and showed expected values of thyroid hormones (mean +/- SD: total T4, 228 +/- 45 nmol/L; total T3, 4.0 +/- 0.65 nmol/L; TSH, 4.0 +/- 1.8 mU/L; negative thyroid antibodies). At birth all newborns were normal on routine examination with no goiter or corneal changes. T4 and TSH, measured on dried umbilical blood spots were normal or borderline-normal in 8 of 9 babies. Only 1 neonate presented clearly abnormal values of T4 and TSH (96 mU/L); on clinical grounds the baby was normal, without signs of hypothyroidism. At 1 month of life, T4 and TSH were normal. Follow-ups at 3, 6, and 12 months were normal. We conclude that is not necessary to discontinue treatment with amiodarone in pregnant women with resistant tachycardia, but it is imperative to evaluate the thyroid function of the newborn, since transient hypothyroidism may occur.

show abstract

Use of amiodarone during pregnancy

Cited by 28 publications

References 4 publications

Congenital Hypothyroid Goiter and Amiodarone

Congenital Hypothyroid Goiter and Amiodarone

Therapeutic monitoring of amiodarone: pharmacokinetics and evaluation of the relationship between effect and dose/concentration

Outcome of Thyroid Function in Newborns from Mothers Treated with Amiodarone

Contact Info

Product

Resources

About