Use of antibiotics and risk of breast cancer: a population-based case–control study

Sørensen, Henrik Toft; Skriver, Mette Vinther; Friis, Søren; Jk, McLaughlin; Blot, William J.; Baron, John A.

doi:10.1038/sj.bjc.6602313

Cited by 37 publications

(37 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In that study, all classes of antibiotics were associated with increased breast cancer risk and the association persisted after adjustment for factors, such as family history of breast cancer, age at menarche, age at birth of first child, age at menopause, postmenopausal estrogen-replacement therapy, cigarette smoking, alcohol intake, and dietary fat intake (2). Other studies have found either no clear association between breast cancer and antibiotic use (3,4) or a low association (5) between breast cancer and a specific antibiotic, such as flucloxacillin, which is commonly used to treat breast cancer abscess and mastitis (6). Thus, it remains unclear whether antibiotic use is causally related to breast cancer or whether there are common mediators of antibiotic exposure and breast cancer.…”

Section: Introductionmentioning

confidence: 74%

Influence of Antibiotic Treatment on Breast Carcinoma Development in Proto-neu Transgenic Mice

Rossini¹,

Rumio

Sfondrini

et al. 2006

Cancer Research

View full text Add to dashboard Cite

The effect of prolonged antibiotic treatments on tumor development was evaluated in proto-neu transgenic mice, which spontaneously develop mammary carcinomas. Virgin transgenic mice were treated with metronidazole/ciprofloxacin or gentamicin through the drinking water. The hazard ratio [HR; 95% confidence interval (95% CI)] of breast cancer occurrence in metronidazole/ciprofloxacin-treated mice was more than triple that for controls [3.11 (1.13-8.53); P = 0.028], whereas only a slight increase in HR (95% CI) was observed in gentamicin-treated mice [1.39 (0.56-3.47); P = 0.481]. Tumor growth rate in gentamicin-treated mice was significantly faster than in untreated control mice (P = 0.043). Moreover, mammary glands from mice treated with either antibiotic regimen showed increased lobulization, with more numerous and more developed terminal ductal lobular units than in controls. These results indicate that prolonged exposure to relevant doses of antibiotics affects the mammary glands in this particular model of HER-2/neu transgenic mice; further studies to understand the precise mechanism by which antibiotic treatments influence mammary gland differentiation are critical. (Cancer Res 2006; 66(12): 6219-24)

show abstract

Section: Introductionmentioning

confidence: 74%

Influence of Antibiotic Treatment on Breast Carcinoma Development in Proto-neu Transgenic Mice

Rossini¹,

Rumio

Sfondrini

et al. 2006

Cancer Research

View full text Add to dashboard Cite

show abstract

“…Similarly, a cohort study in Finland found that antibiotic use for urinary tract infections was associated with increased risk of breast cancer in women under 50 years old, compared to women without such usage [2]. However, two recent case-control studies in the United Kingdom and Denmark found no association between antibiotic use and breast cancer risk [3,4]. Thus, it remains unclear whether antibiotic use is a risk factor for breast cancer, or whether other factors associated with both antibiotic use and breast cancer, such as heightened medical care, are responsible for the observed associations in several studies [1,2].…”

Section: Introductionmentioning

confidence: 98%

Association between Antibiotic use Prior to Breast Cancer Diagnosis and Breast Tumour Characteristics (United States)

Velicer

Heckbert

Rutter

et al. 2006

Cancer Causes Control

View full text Add to dashboard Cite

show abstract

“…Based on surveys of diabetic patients between 2000 and 2003, f97% of subscribers have at least partial payment for prescriptions covered by KPMCP and f93% of subscribers fill all of their prescriptions at KPMCP pharmacies. 4 Women ages z20 years with KPMCP drug coverage were identified and followed up starting in August 1994, when implementation of PIMS in all KPMCP pharmacies was completed. Followup began at the time of both joining the program and having drug coverage, if later than August 1994.…”

Section: Methodsmentioning

confidence: 99%

Antibiotics and Risk of Breast Cancer: Up to 9 Years of Follow-up of 2.1 Million Women

Friedman

Oestreicher²,

Chan

et al. 2006

Cancer Epidemiology, Biomarkers &Amp; Prevention

View full text Add to dashboard Cite

Antibiotic use has been associated with risk of breast cancer in previous reports. Using Cox proportional hazards analysis, we evaluated this association in 2,130,829 adult female subscribers of a health care program according to their receipt of prescriptions of antibiotics from outpatient pharmacies. Hormone use was taken into account. Altogether, 18,521 women developed breast cancer in up to 9.4 years of follow-up. Use of any antibiotic was associated with slightly increased risk [hazard ratio (HR), 1.14; 95% confidence interval (95% CI), 1.10-1.18] but there was little, if any, evidence of dose response, with HR of 1.17 (95% CI, 0.97-1.42) for >1,000 days of use compared with no use. The only two weakly associated antibiotic groups (HR >1.10 for >100 days of use) were tetracyclines and macrolides with HRs (95% CI) of 1.23 (1.11-1.36) and 1.16 (0.98-1.36), respectively. An association of lincosamides with breast cancer in an earlier, smaller database was not confirmed, but follow-up was too short in the present data for adequate evaluation. Medical record review suggested that acne and/or rosacea could be the underlying factor, associated with long-term antibiotic therapy and found by others to be associated with risk of breast cancer. Although causality cannot be ruled out, the observed associations of antibiotics overall, tetracyclines, and macrolides with breast cancer were weak and could be explained by uncontrolled confounding by the diseases being treated or by other factors. (Cancer Epidemiol Biomarkers Prev 2006;15(11):2102 -6)

show abstract

Use of antibiotics and risk of breast cancer: a population-based case–control study

Cited by 37 publications

References 10 publications

Influence of Antibiotic Treatment on Breast Carcinoma Development in Proto-neu Transgenic Mice

Influence of Antibiotic Treatment on Breast Carcinoma Development in Proto-neu Transgenic Mice

Association between Antibiotic use Prior to Breast Cancer Diagnosis and Breast Tumour Characteristics (United States)

Antibiotics and Risk of Breast Cancer: Up to 9 Years of Follow-up of 2.1 Million Women

Contact Info

Product

Resources

About