Use of Azithromycin for the Prevention of Bronchopulmonary Dysplasia: A Randomized, Double-Blind, Placebo Controlled Trial.

Ho, Ballard; Bernard, PA; Hayes, Diane; Anstead, MI; Ns, Desai; Smart, E.R.; Shook, LA

doi:10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a4126

C26. Basic and Clinical Studies on Bronchopulmonary Dysplasia 2009

DOI: 10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a4126

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Use of Azithromycin for the Prevention of Bronchopulmonary Dysplasia: A Randomized, Double-Blind, Placebo Controlled Trial.

Ballard Ho¹,

PA Bernard²,

Diane Hayes³

et al.

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Pathogenesis of Bronchopulmonary Dysplasia

et al. 2009

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Bronchopulmonary dysplasia (BPD) refers to a heterogeneous group of lung disorders in infants that is commonly associated with prematurity and surfactant deficiency. BPD results from the complex interplay between impairments in the premature lung such as surfactant deficiency, perinatal insults such as infection, and damage resulting from supportive care of the infant due to barotrauma or volutrauma from mechanical ventilation and oxygen toxicity from supplemental oxygen administration. These factors result in chronic inflammation in the infant lung with recurring cycles of lung damage and repair that may impair alveolarization and vascularization in the developing lungs. As our insight in how to treat BPD improves along with the ability to do so with developing technology and therapies, the underlying pathogenesis will also change. The term ‘new’ BPD is now commonly used, to describe the changes seen in the post-surfactant era. This discussion reviews the pathogenesis of BPD according to the current medical literature.

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Pathogenesis of Bronchopulmonary Dysplasia

et al. 2009

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Use of Azithromycin for the Prevention of Bronchopulmonary Dysplasia: A Randomized, Double-Blind, Placebo Controlled Trial.

Cited by 1 publication

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Pathogenesis of Bronchopulmonary Dysplasia

Pathogenesis of Bronchopulmonary Dysplasia

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