Use of “BioGlue” in aortic surgical repair

Raanani, Ehud; Latter, David A.; Errett, Lee; Bonneau, D.; Leclerc, Yves; Salasidis, Gary C

doi:10.1016/s0003-4975(01)02663-7

Cited by 59 publications

(35 citation statements)

References 4 publications

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“…It is a powerful surgical adhesive that has been used extensively in cardiac, pulmonary, and vascular surgery with excellent results [31][32][33][34][35][36][37]. The BioGlue seeps easily through the porous knitted Vicryl mesh to adhere to the underlying crural tissues.…”

Section: Discussionmentioning

confidence: 99%

A simplified technique for intrathoracic stomach repair: laparoscopic fundoplication with Vicryl mesh and BioGlue crural reinforcement

et al. 2009

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Section: Discussionmentioning

confidence: 99%

A simplified technique for intrathoracic stomach repair: laparoscopic fundoplication with Vicryl mesh and BioGlue crural reinforcement

et al. 2009

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“…The tissue adhesive polymerizes from its constituents via a "Schiff's reaction" between aldehydes and amines (Fig 3). 15 The amines for this reaction are supplied by the bovine serum albumin molecules and the surrounding tissue. 15 Exposure to glutaraldehyde causes lysine molecules of bovine serum albumin, extracellular matrix proteins, and cell surfaces to bind to each other, creating a strong scaffold.…”

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confidence: 99%

Seroma Prevention Using an Albumin–Glutaraldehyde-Based Tissue Adhesive in the Rat Mastectomy Model

Menon

Downing

Goldberg

et al. 2003

Annals of Plastic Surgery

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Seroma formation is a common postoperative complication in plastic surgery, resulting in notable patient morbidity and expense. In this study the authors investigated the efficacy of a synthetic glutaraldehyde-based tissue adhesive (BioGlue; Cryolife, Inc., Kennesaw, GA) in seroma prevention in the rat mastectomy seroma model. This tissue adhesive is composed of purified bovine serum albumin (45%) and glutaraldehyde (10%). Twenty-two Sprague-Dawley rats received mastectomies along with axillary lymphadenectomy and disruption of subcutaneous lymphatics. The control group (N = 11) received 2.5 ml saline into the wound before closure. In the experimental group (N = 11), 2.5 ml BioGlue was injected into the wound. On postoperative day 7, the resultant seromas were quantified and adjacent tissues were harvested for histological examination. The rats in the control group had a mean seroma volume of 5.19 ml (standard deviation, +/- 3.65 ml; N = 11), whereas the rats treated with BioGlue had a mean seroma volume of 0.25 +/- 0.43 ml (N = 11). Histology revealed an inflammatory response consistent with postoperative changes as well as a mild foreign body reaction. This study demonstrates that BioGlue can be used as a tissue adhesive that reduces seroma formation significantly in the rat mastectomy model (p = 0.0008). Further studies are warranted to investigate the long-term effect of BioGlue on surrounding tissue.

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“…BioGlue was approved for use in cardiovascular surgery by the FDA in 2001 (7). Although several animal studies and clinical reports have illuminated the benefits of using BioGlue in aortic surgical operations over the past 15 years (8)(9)(10)(11), some reports suggest that BioGlue may severely injure the aortic tissue, ultimately leading to re-dissection or pseudoaneurysm formation at the anastomotic sites (1,9,10,(12)(13)(14)(15)(16). This study increases the patient number of an earlier pilot study we published previously (14) and aims to examine whether the use of BioGlue is associated with a high incidence of anastomotic pseudoaneurysm formation following surgical repair of thoracic aortic disease.…”

Section: Introductionmentioning

confidence: 99%

Does BioGlue contribute to anastomotic pseudoaneurysm after thoracic aortic surgery?

Ziganshin

Guo

et al. 2017

J. Thorac. Dis.

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Background: Although bovine serum albumin-glutaraldehyde glue (BioGlue®) has been successfully used as a hemostatic adjunct in aortic surgical procedures, there are reports that it may lead to anastomotic pseudoaneurysm formation. We seek to examine if the use of BioGlue is associated with a high incidence of anastomotic pseudoaneurysm formation following surgical repair of thoracic aortic disease. Methods:We reviewed the medical records and follow-up computed tomography (CT) scans of patients from 2001 to 2015 in whom BioGlue was used during surgical repair of thoracic aortic disease to detect postoperative anastomotic pseudoaneurysm formation.Results: A total of 233 patients with BioGlue use were identified. Mean age was 63.5±14.0 years (median 66; range 14-88; 25-75%, IQR 54-74 years) and 149 were male (63.9%). Surgical indication was thoracic aortic aneurysm in 169 (72.5%) patients, aortic dissection in 49 (21.0%), intramural hematoma in 9 (3.9%), penetrating aortic ulcer in 3 (1.3%) and other in 3 (1.3%). Emergency/urgent surgery was performed in 68 cases (29.2%). Operative mortality was 7.3% (17/233). Re-exploration for bleeding and neurologic deficits occurred in 24 (10.3%) and 21 (9.0%) patients respectively. All operative survivors were followed (100%, 216/216) and CT follow-up was available in 81.9% (177/216) for a mean duration of 2.4 years (median 0.6; 25-75% IQR 0.2-3.6 years). Anastomotic pseudoaneurysm was detected in 1 patient (0.6%) at 3 years postoperatively. This was an elderly female with extremely frail tissues who underwent a reoperative ascending and arch replacement for dissection. Conclusions:The use of BioGlue in thoracic aortic surgery was not associated with excess incidence of anastomotic pseudoaneurysm formation following surgical repair of thoracic aortic disease. Its use need not be discouraged on this basis.

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Use of “BioGlue” in aortic surgical repair

Cited by 59 publications

References 4 publications

A simplified technique for intrathoracic stomach repair: laparoscopic fundoplication with Vicryl mesh and BioGlue crural reinforcement

A simplified technique for intrathoracic stomach repair: laparoscopic fundoplication with Vicryl mesh and BioGlue crural reinforcement

Seroma Prevention Using an Albumin–Glutaraldehyde-Based Tissue Adhesive in the Rat Mastectomy Model

Does BioGlue contribute to anastomotic pseudoaneurysm after thoracic aortic surgery?

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