Use of biomarkers in an indoor air study: lack of correlation between aromatic VOCs with respective urinary biomarkers

Isbell, Maggie; Ricker, Janet; Gordian, Mary Ellen; Duffy, Lawrence K.

doi:10.1016/s0048-9697(99)00343-5

Cited by 8 publications

(2 citation statements)

References 24 publications

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“…Others, however, have not found significant correlations, at occupational exposure levels lower than 0.25 ppm (Gobba et al, 1997;Ong et al, 1996). In addition, several authors have reported the occasional observation of unexpectedly high MA levels in non-occupationally exposed control subjects (Gobba et al, 1997;Isabell et al, 1999;Johnson et al, 1992;Qu et al, 2000;Weaver et al, 1996). The French mean daily intake of sorbic acid and its salts was estimated at 2.63 mg/kgday which corresponds to 184 mg/day ingestion for a 70 kg adult (Verger et al, 1998).…”

Section: Discussionmentioning

confidence: 98%

Environmental benzene exposure assessment for parent–child pairs in Rouen, France

Kouniali

Cicolella

Gonzalez-Flesca

et al. 2003

Science of The Total Environment

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There is a lack of data on environmental benzene exposure in children. In this study, we compared personal benzene exposure and inhalation uptake in a group of children to those of their parents. We also compared levels of urinary benzene metabolites, trans,trans-muconic acid (MA) and hydroquinone (HQ), for those two groups, and assessed the correlation between personal benzene exposure and urinary MA and HQ concentrations. The study was performed on 21, 2-3-year-old children and their parents recruited on a voluntary basis among non-smokers from the three largest day-care centers of the town of Rouen in France. Average benzene concentrations were measured over 5 consecutive days with diffusive samplers. The following simultaneous measurements were carried out: personal exposure of the parents, concentrations inside and outside the day care centers, and inside the volunteer's bedrooms. Morning and evening urine samples were collected during the same period. Benzene personal exposure levels were 14.4+/-7.7 microg/m(3) and 11.09+/-6.15 microg/m(3) in parents and children, respectively. Benzene inhalation uptake estimates were 2.51+/-1.23 microg/kg/day in the group of parents and 5.68+/-3.17 microg/kg/day in the group of children. Detectable levels of MA and HQ were found in 85% and 100% of the samples, respectively. Intra-individual variation of urinary MA and HQ concentrations expressed as a coefficient of variation (CV) ranged from 63 to 232% and from 13 to 144%, respectively. Mean values of MA and HQ (in mg/g creatinine) were 1.6- and 1.8-fold higher in the group of children than in the group of parents (P=0.008 and P<0.0001, respectively). Significant correlations between metabolites levels and benzene were not found.

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Section: Discussionmentioning

confidence: 98%

Environmental benzene exposure assessment for parent–child pairs in Rouen, France

Kouniali

Cicolella

Gonzalez-Flesca

et al. 2003

Science of The Total Environment

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“…Low-concentration volatile organic compounds (VOCs) in indoor environments, mainly including benzene, toluene and xylenes (BTX) [1][2][3], have been correlated to adverse health effects such as allergic reactions; headache; eye, nose or throat irritation; dry cough; dizziness and nausea; tiredness and even cancer [4,5]. As a result of "sick building syndrome", the productivity in offices decreases by 6.5% in average [6].…”

Section: Introductionmentioning

confidence: 99%

Effects of humidity on the plasma-catalytic removal of low-concentration BTX in air

Fan

Zhu

Wan

et al. 2010

Journal of Hazardous Materials

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Non-Thermal Plasma for indoor air treatment: Toluene degradation in a corona discharge at ppbv levels

Ondarts

Hajji

Outin

et al. 2017

Chemical Engineering Research and Design

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Use of biomarkers in an indoor air study: lack of correlation between aromatic VOCs with respective urinary biomarkers

Cited by 8 publications

References 24 publications

Environmental benzene exposure assessment for parent–child pairs in Rouen, France

Environmental benzene exposure assessment for parent–child pairs in Rouen, France

Effects of humidity on the plasma-catalytic removal of low-concentration BTX in air

Non-Thermal Plasma for indoor air treatment: Toluene degradation in a corona discharge at ppbv levels

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