Use of bovine pericardium graft for abdominal wall reconstruction in contaminated fields

D’Ambra, Luigi; Berti, Stefano; Feleppa, Cosimo; Magistrelli, Prospero; Bonfante, Pierfrancesco; Falcò, Emilio

doi:10.4240/wjgs.v4.i7.171

Cited by 25 publications

(23 citation statements)

References 13 publications

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“…Nevertheless, it may have a high rejection rate and adhesion to surrounding tissues, be more allergic, and be associated with calculi formation in patients undergoing urologic or vascular surgeries [8,61]. In contrast, BP has been demonstrated to be associated with no evidence of calcification, infection, thromboembolic events, or failure in pediatrics undergoing cardiac surgeries [62,63]. Additionally, it is deemed an appropriate graft in infected tissues [62].…”

Section: Pericardial Tissue Features and Feasibilitymentioning

confidence: 99%

Pericardium in Reconstructive Urologic Surgeries: A Systematic Review and Meta-Analysis

Hosseini

et al. 2018

Urol Int

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Introduction: The use of pericardium has been expanded into different surgical modalities; however, there are scarce data regarding the feasibility of the pericardium in reconstructive urologic surgeries. We systematically reviewed the literature on the effectiveness of the pericardial tissue for reconstructive urologic surgeries. Materials and Methods: PubMed and Scopus were searched online for evidence on the use of the pericardium in urologic surgeries. Through the methodology recommended by the Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines, 38 of 4,071 studies were identified. Results: A total of 715 patients and 139 animals underwent reconstructive urologic surgeries using the pericardium. Bladder, urethral, and renal reconstructions were successful in 100% of the human cases. The rates of dissatisfaction, glans hypoesthesia, and penile shortening were comparable between the pericardial graft surgeries and the other operations during penile straightening, but there was a trend among the patients with pericardial grafts toward having a more penile curvature at follow-up (risk ratio [RR] 2.03, 95% CI 0.90–4.61, p = 0.09; I² = 0%). Among the animal studies, there were 4 reports of penile reconstruction, 7 studies of bladder reconstruction, and 1 study of urethroplasty. Bladder reconstruction and urethroplasty were successful in 83 and 20% of the animals, respectively. The pooled result of the stimulated intracorporeal pressure 5 V significantly favored pericardial grafts during penile reconstruction (RR 2.61, 95% CI 1.26–3.97, p = 0.0002; I² = 0%). Conclusions: Our systematic review demonstrates the feasibility of the pericardium, regardless of its type, in urologic surgeries. It, however, seems that urethral substitution needs further investigation. Given the lower cost, easier handling, and less immunogenicity of the pericardium, further studies are required to examine its pros and cons.

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Section: Pericardial Tissue Features and Feasibilitymentioning

confidence: 99%

Pericardium in Reconstructive Urologic Surgeries: A Systematic Review and Meta-Analysis

Hosseini

et al. 2018

Urol Int

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“…It is a reliable substrate because of the effective mechanical support, biocompatibility with host tissues, and minimal tissue irritation. 7,8 Recent studies have examined the use of acellular bovine pericardium (ABP) grafts as a scaffold in pelvic floor reconstruction. 9 Human adipose-derived stem cells (hASCs) are a suitable option for reseeding, because it is convenient to harvest them in large quantities using minimally invasive techniques, and additionally, these MSCs maybe reduce the immune response.…”

Section: Introductionmentioning

confidence: 99%

In vivo effects of human adipose-derived stem cells reseeding on acellular bovine pericardium in nude mice

Dai

et al. 2015

Exp Biol Med (Maywood)

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Tissue-engineered biologic products may be a viable option in the reconstruction of pelvic organ prolapse (POP). This study was based on the hypothesis that human adipose-derived stem cells (hASCs) are viable in acellular bovine pericardium (ABP), when reseeded by two different techniques, and thus, aid in the reconstruction. To investigate the reseeding of hASCs on ABP grafts by using non-invasive bioluminescence imaging (BLI), and to identify the effective hASCs-scaffold combinations that enabled regeneration. Thirty female athymic nude mice were randomly divided into three groups: In the VIVO group, ABPs were implanted in the subcutaneous pockets and enhanced green fluorescent protein luciferase (eGFPÁLuc)-hASCs (1 Â 10 6 cells/50 mL) were injected on the ABP at the same time. In the VITRO group, the mice were implanted with grafts that ABP were co-cultured with eGFPÁLuc-hASCs in vitro. The BLANK group mice were implanted with ABP only. The eGFPÁLuc-hASCs reseeded on ABP were analyzed by BLI, histology, and immunohistochemistry. The eGFPÁLuc-hASCs reseeded on ABP could be visualized at 12 weeks in vivo. Histology revealed that the VIVO group displayed the highest cell ingrowths, small vessels, and percent of collagen content per unit area. Desmin and a-smooth muscle actin were positive at the same site in the VIVO group cells. However, few smooth muscles were observed in the VITRO and BLANK groups. These results suggest that hASCs reseeded on ABP in vivo during surgery may further enhance the properties of ABP and may promote regeneration at the recipient site, resulting in a promising treatment option for POP.

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“…Bovine pericardium appears to have a lower complication rate (ranging between 3% and 10% in the studies examined [39][40][41] ) and recurrence rate (0%-19%) than other biologic mesh products ( in the field of AWR. A recent study of 120 patients who underwent a non-bridge inlay AWR with either porcine acellular dermal matrix (69 patients) or bovine acellular dermal matrix (51 patients) demonstrated significantly lower overall complication rates with bovine acellular dermal matrix (44.9% overall complications in the porcine acellular dermal matrix group versus 25.5% in the bovine acellular dermal matrix group).…”

Section: Bovine Pericardium and Dermal Meshmentioning

confidence: 99%

“…39 D'Ambra et al studied 48 contaminated abdominal wall repairs with bovine pericardium and found a recurrence rate of 8% and wound complication rate of 10% over a mean follow-up of 22 months. 40 A recent study by Gurrado et al demonstrated a 3% wound-infection rate and 0% recurrence rate in a study of contaminated incisional hernia repair with bovine pericardium. Gurrado et al compared the wound-infection and recurrence rates to contaminated incisional hernia repairs with synthetic mesh and suture repair alone and found that bovine pericardium was associated with significantly lower rates of both endpoints.…”

Section: Bovine Pericardium and Dermal Meshmentioning

confidence: 99%

Biologic mesh for abdominal wall reconstruction

King¹,

Albino²,

Bhanot³

2014

CWCMR

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Background: Mesh reinforcement significantly decreases rates of recurrence following ventral hernia repair. Historically, biologic mesh was touted as superior in the setting of infection; however, selecting the appropriate mesh for a given clinical scenario is often a matter of debate. The purpose of this review is to highlight a number of the more commonly used biologic mesh products with a review of outcomes from the current literature. Methods: Outcomes following abdominal wall reconstruction using biologic mesh were reviewed for acellular cadaveric human dermis, cross-linked porcine dermis, non-cross-linked porcine dermis, porcine small intestine submucosa, acellular bovine pericardial, and acellular bovine dermal mesh. Studies with rigorous methods, adequate patient samples, and sufficient follow-up were selected for review. Results: Hernia recurrence rates following biologic mesh reinforcement vary widely. Porcine small intestine submucosa and bovine pericardium were associated with the lowest hernia recurrence rates. Porcine cross-linked dermal mesh products resulted in higher rates of adhesion formation and lower rates of tissue incorporation compared to non-cross-linked porcine mesh. Conclusion: Successful ventral hernia repair can be achieved with acceptable complications rates for each of the reviewed mesh products. Biologic meshes have an advantage over synthetic mesh in contaminated wounds but their use may not be cost-effective in all patient populations. Those with and/or at high risk for wound complications may also undergo repair with biologic mesh.

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Use of bovine pericardium graft for abdominal wall reconstruction in contaminated fields

Cited by 25 publications

References 13 publications

Pericardium in Reconstructive Urologic Surgeries: A Systematic Review and Meta-Analysis

Pericardium in Reconstructive Urologic Surgeries: A Systematic Review and Meta-Analysis

In vivo effects of human adipose-derived stem cells reseeding on acellular bovine pericardium in nude mice

Biologic mesh for abdominal wall reconstruction

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