The objective of this paper is to present the thermal behavior of various PMMA/TiO2 nanocomposite for complete dentures fabrication with 3D printing technology. There have been prepared and thermally characterized polymeric composites with varied nanofiller content ranging between 0.2% and 2.5% (w/w%). The nanocomposites proved a better thermal performance than that of pure copolymer PMMA-MMA or 3D printing PMMA polymer complex matrix. A small difference in glass transition (Tg) temperature for all compounds studied was recorded.