Use of cDNA arrays to generate differential expression profiles for inflammatory genes in human gestational membranes delivered at term and preterm

Marvin, Keith W.; Keelan, Jeffrey A.; Eykholt, R.L.; Sato, Timothy A.; Mitchell, Murray D.

doi:10.1093/molehr/8.4.399

Cited by 113 publications

(103 citation statements)

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“…Functional genomics has arrived at the study of parturition in different species: mice (Bethin et al 2003, Salomonis et al 2005; rats (Girotti & Zingg 2003) and humans (Chan et al 2002, Marvin et al 2002a, 2002b, Tashima et al 2002, Bethin et al 2003, Charpigny et al 2003, Keelan et al 2003, Esplin et al 2005, Havelock et al 2005. Also in different tissues: myometrium (Aguan et al 2000, Chan et al 2002, Bethin et al 2003, Charpigny et al 2003, Esplin et al 2005, Havelock et al 2005, Salomonis et al 2005; primary cultures of human myometrial cells ; fetal membranes (Muhle et al 2001, Chen et al 2002, Marvin et al 2002a, 2002b, Tashima et al 2002, Keelan et al 2003 and trophoblasts (Chen et al 2002, Kato et al 2002.…”

Section: Functional Genomic Studies During Pregnancymentioning

confidence: 99%

“…Also in different tissues: myometrium (Aguan et al 2000, Chan et al 2002, Bethin et al 2003, Charpigny et al 2003, Esplin et al 2005, Havelock et al 2005, Salomonis et al 2005; primary cultures of human myometrial cells ; fetal membranes (Muhle et al 2001, Chen et al 2002, Marvin et al 2002a, 2002b, Tashima et al 2002, Keelan et al 2003 and trophoblasts (Chen et al 2002, Kato et al 2002. Various methodologies have been used: suppression subtractive hybridization (SSH) (Chan et al 2002) or microarrays for most of the previous cited studies.…”

Section: Functional Genomic Studies During Pregnancymentioning

confidence: 99%

“…Various methodologies have been used: suppression subtractive hybridization (SSH) (Chan et al 2002) or microarrays for most of the previous cited studies. All investigators have reported genes differentially regulated during parturition and multiple novel candidate markers for preterm labor (Wu et al 1999, Chan et al 2002, Marvin et al 2002a, 2002b. They contributed to shed light on specific pathophysiological issues such as the patterns of expression of cytokines in the fetal membranes and decidua particularly in the presence of intrauterine infection (Keelan et al 2003) or on the induction of enzymes for prostaglandin synthesis (Bethin et al 2003) which are commonly associated with the onset of labor.…”

Section: Functional Genomic Studies During Pregnancymentioning

confidence: 99%

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Gene and protein expression in the myometrium in pregnancy and labor

Breuiller-Fouché¹,

Germain²

2006

Reproduction

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Microarray technologies widen our comprehension of the major structural and metabolic transformations which affect the myometrium from the very beginning of pregnancy until parturition. The results are coherent with the mass of information which was accumulated previously, primarily on the basis of studies of selected critical factors. They highlight the activation of precise signaling pathways, some of which may have been previously under evaluated. The remodelling and maturation processes that the myometrium undergoes in pregnancy appear clearly as phenomena which last during the full course of gestation. Comparatively, the onset of labor is perhaps the phenomenon which remains the least well described by these methods of analysis. Nevertheless, genomic studies constitute a necessary first step of orientation and help establishing new links between the generic signaling pathways that are activated during the normal or pathological gestation. These studies also represent an indicative step that will have to be paralleled, in the future, with the results of the systematic proteomic analysis of the myometrium.

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Section: Functional Genomic Studies During Pregnancymentioning

confidence: 99%

Section: Functional Genomic Studies During Pregnancymentioning

confidence: 99%

Section: Functional Genomic Studies During Pregnancymentioning

confidence: 99%

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Gene and protein expression in the myometrium in pregnancy and labor

Breuiller-Fouché¹,

Germain²

2006

Reproduction

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“…Inflammation is now widely accepted to be a key feature of human labour. Microarray and suppression subtractive hybridization studies have demonstrated the up-regulation of a large panel of pro-inflammatory genes in both fetal membranes (Marvin et al 2002, Bethin et al 2003 and myometrium (Chan et al 2002, Charpigny et al 2003 with labour onset. Extensive work over the last two decades has implicated cytokines and prostaglandins in the parturition process.…”

Section: Introductionmentioning

confidence: 99%

The role of nuclear factor kappa B in human labour

Lindström

Bennett²

2005

Reproduction

273

237

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Preterm birth remains the leading cause of perinatal mortality and morbidity, largely as a result of a poor understanding of the precise mechanisms controlling labour onset in humans. Inflammation has long been recognised as a key feature of both preterm and term labour, with an influx of inflammatory cells into the uterus and elevated levels of pro-inflammatory cytokines observed during parturition. Nuclear factor kappa B (NF-kB) is a transcription factor family classically associated with inflammation. Accumulating evidence points to a role for NF-kB in the physiology and pathophysiology of labour. NF-kB activity increases with labour onset and is central to multiple pro-labour pathways. Premature or aberrant activation of NF-kB may thus contribute to preterm labour. The current understanding of NF-kB in the context of human labour is discussed here.

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“…This concept opens up new possibilities to relate stress to the immune system, possibly leading to the risk of infection, (and thus increased risk of premature delivery), with or without associated polymorphism, depending on the genetic susceptibility to inflammation, the inflammation present before and during pregnancy and the allostatic overload of women. Allostatic overload is defined as the wear of the neuro-endocrine systems, for an extreme activity or too low, in response to the tensions and the need to adapt [4]. The allostatic overload quantifies the physiological and neuroendocrinological fluctuating changes of the organism, produced by the acute and chronic psychosocial stress, over time.…”

Section: Interaction Between Maternal Stress and Preterm Deliverymentioning

confidence: 99%

Eugenic Therapy and the Metabolic Syndrome

Quintero¹

2017

Epidemiology

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SummaryIndependent of the clinical syndrome that results in chronic inflammation, there is an overlap of the different etiopathogenic factors in the most common diseases of the modern era. Its pathogenesis also has similar pathophysiological mechanisms. Independent of the clinical syndrome that results in chronic inflammation, there is an overlap of the different etiopathogenic factors in the most common diseases of the modern era. Its pathogenesis also has similar pathophysiological mechanisms. These two facts prompt us, independent of the particular therapeutic connotations for each disease, to establish certain measures of prevention and treatment, also common, where precisely the holistic treatments that seek to Systemic homeostasis, are appropriate. These are the biological treatments, where the homo-toxicology, without a doubt, stands out as one of the best therapeutic alternatives.The universal concept of inflammation allows us to understand more than just the symptom and going beyond a therapeutic protocol, unfortunately a lasting solution is not in our hands and may be the anthropology, sociology and ecology, the sciences involved in the definitive solutions. In the meantime, to understand that the chronic disease of the adult may have originated during gestation or before the same. We have to look at humanity in full, in its family nucleus, interacting with an environment, in a dynamic process, involutionary and evolutionary at the same time, but it will be the knowledge of our own nature which will allow a better pathogenetic and therapeutic approach.At the end of the first millennium and the start of the second a new profile in sicknesses made itself evident and it would be naive as to think that there was no epidemic relationships between the illnesses that made them up. In today's society, the analysis of each individual sickness, without taking into account the biological changes surrounding the environment in the development of modern day life, would isolate man as a strange object in his own universe and perpetuate the reductionist concept of the Cartesian medicine where the dismembering of the human body in its sickness makes an important part of its philosophy. Under the integration prism of the environmental conditions we shall analyse the epidemic variants in the prevailing illnesses. And in one medical concept we will integrate the environmental changes with the psycho, neuro, endocrine and immunological alterations of the organism, which is the origin of almost all human disease.Keeping in mind the environmental conditions for thousands of years in the life development were relatively stable. Evolution made a permanent adjustment that allows the successful existence of life on the planet. Unfortunately, in the last few decades, human life and its relation with the stability of nature around it have changed in such a violent and extreme manner that the human being, from the biological point of view, is not prepared to defend and prosses the information which an adverse environment supplies ...

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Use of cDNA arrays to generate differential expression profiles for inflammatory genes in human gestational membranes delivered at term and preterm

Cited by 113 publications

References 76 publications

Gene and protein expression in the myometrium in pregnancy and labor

Gene and protein expression in the myometrium in pregnancy and labor

The role of nuclear factor kappa B in human labour

Eugenic Therapy and the Metabolic Syndrome

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