Use of Cerium Oxide Nanoparticles Conjugated with MicroRNA-146a to Correct the Diabetic Wound Healing Impairment

Zgheib, Carlos; Hilton, Sarah A.; Dewberry, Lindel C.; Hodges, Maggie M.; Ghatak, Subhadip; Xu, Jie; Singh, Sushant; Roy, Sashwati; Sen, Chandan K.; Seal, Sudipta; Liechty, Kenneth W.

doi:10.1016/j.jamcollsurg.2018.09.017

Cited by 115 publications

(113 citation statements)

References 27 publications

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“…In this model, diabetic wounds treated with miR-146a conjugated to cerium oxide NPs (miR-146a-CeO-NP) were significantly smaller in size respect to the wounds treated with PBS (Phosphate Buffer Saline). Moreover, diabetic wounds of the same pigs treated with miR-146-CeO-NP also showed a decreased frequency of CD45 + immune cells, indicating a reduction of inflammatory processes [120].…”

Section: Inorganic Nanoparticlesmentioning

confidence: 90%

Targeting microRNAs as a Therapeutic Strategy to Reduce Oxidative Stress in Diabetes

Grieco

Brusco

Licata

et al. 2019

IJMS

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Diabetes mellitus is a group of heterogeneous metabolic disorders characterized by chronic hyperglycaemia as a consequence of pancreatic β cell loss and/or dysfunction, also caused by oxidative stress. The molecular mechanisms involved inβ cell dysfunction and in response to oxidative stress are also regulated by microRNAs (miRNAs). miRNAs are a class of negative gene regulators, which modulate pathologic mechanisms occurring in diabetes and its complications. Although several pharmacological therapies specifically targeting miRNAs have already been developed and brought to the clinic, most previous miRNA-based drug delivery methods were unable to target a specific miRNA in a single cell type or tissue, leading to important off-target effects. In order to overcome these issues, aptamers and nanoparticles have been described as non-cytotoxic vehicles for miRNA-based drug delivery. These approaches could represent an innovative way to specifically target and modulate miRNAs involved in oxidative stress in diabetes and its complications. Therefore, the aims of this review are: (i) to report the role of miRNAs involved in oxidative stress in diabetes as promising therapeutic targets; (ii) to shed light onto the new delivery strategies developed to modulate the expression of miRNAs in diseases.

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Section: Inorganic Nanoparticlesmentioning

confidence: 90%

Targeting microRNAs as a Therapeutic Strategy to Reduce Oxidative Stress in Diabetes

Grieco

Brusco

Licata

et al. 2019

IJMS

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“…While this evidence is indirect, these data suggest that the downregulated expression of miR-146a in response to injury in diabetic wounds could in part be responsible for the abnormal inflammatory response observed in diabetic wounds [ 136 ]. Moreover, the application of miR-146a conjugated with cerium oxide nanoparticles improved wound healing in diabetic mice without impairing the biomechanical properties of the healed skin ( Table 2 , Table 3 and Table 4 ) [ 139 ].…”

Section: Micrornas Altered In Diabetic Wound Healingmentioning

confidence: 99%

Mechanistic Actions of microRNAs in Diabetic Wound Healing

Petković

Sørensen

Leal

et al. 2020

Cells

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Wound healing is a complex biological process that is impaired under diabetes conditions. Chronic non-healing wounds in diabetes are some of the most expensive healthcare expenditures worldwide. Early diagnosis and efficacious treatment strategies are needed. microRNAs (miRNAs), a class of 18–25 nucleotide long RNAs, are important regulatory molecules involved in gene expression regulation and in the repression of translation, controlling protein expression in health and disease. Recently, miRNAs have emerged as critical players in impaired wound healing and could be targets for potential therapies for non-healing wounds. Here, we review and discuss the mechanistic background of miRNA actions in chronic wounds that can shed the light on their utilization as specific wound healing biomarkers.

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“…It has been demonstrated that the administration of varying concentrations of nanoceria-miR-146a (1, 10, 100, and 1000 ng) may be effective in treating diabetic wounds created on the dorsal skin of Db/Db mice. Although the treatment with 10, 100, or 1000 ng of nanoceria-miR-146a was effective in wound healing within 14 days post-administration, a 100-ng dosage was found as the optimum concentration of the nano-dressing [ 106 ].…”

Section: Nanoceria For Soft-tissue Engineeringmentioning

confidence: 99%

Cerium Oxide Nanoparticles (Nanoceria): Hopes in Soft Tissue Engineering

et al. 2020

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Several biocompatible materials have been applied for managing soft tissue lesions; cerium oxide nanoparticles (CNPs, or nanoceria) are among the most promising candidates due to their outstanding properties, including antioxidant, anti-inflammatory, antibacterial, and angiogenic activities. Much attention should be paid to the physical properties of nanoceria, since most of its biological characteristics are directly determined by some of these relevant parameters, including the particle size and shape. Nanoceria, either in bare or functionalized forms, showed the excellent capability of accelerating the healing process of both acute and chronic wounds. The skin, heart, nervous system, and ophthalmic tissues are the main targets of nanoceria-based therapies, and the other soft tissues may also be evaluated in upcoming experimental studies. For the repair and regeneration of soft tissue damage and defects, nanoceria-incorporated film, hydrogel, and nanofibrous scaffolds have been proven to be highly suitable replacements with satisfactory outcomes. Still, some concerns have remained regarding the long-term effects of nanoceria administration for human tissues and organs, such as its clearance from the vital organs. Moreover, looking at the future, it seems necessary to design and develop three-dimensional (3D) printed scaffolds containing nanoceria for possible use in the concepts of personalized medicine.

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Use of Cerium Oxide Nanoparticles Conjugated with MicroRNA-146a to Correct the Diabetic Wound Healing Impairment

Cited by 115 publications

References 27 publications

Targeting microRNAs as a Therapeutic Strategy to Reduce Oxidative Stress in Diabetes

Targeting microRNAs as a Therapeutic Strategy to Reduce Oxidative Stress in Diabetes

Mechanistic Actions of microRNAs in Diabetic Wound Healing

Cerium Oxide Nanoparticles (Nanoceria): Hopes in Soft Tissue Engineering

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