Use of charged and neutral cyclodextrins in capillary zone electrophoresis: enantiomeric resolution of some 2-hydroxy acids

Chiral interactions in capillary zone electrophoresis: Computer simulation and comparison with experiment

“…The L(+)-isomer of mandelic acid migrated slower than the D(-), and therefore KLI>KD,. This confirms earlier experiments of Nardi et al [12]. Fanali [13] showed that (+)-terbutaline has the highest afinity towards the CD cavity.…”

Histamine-modified cationic β-cyclodextrins as chiral selectors for the enantiomeric separation of hydroxy acids and carboxylic acids by capillary electrophoresis

“…A -methylamino-and 6 A ,6 D -dimethylamino-b-CD studied by Fanali et al [42] and the 6-deoxy-6-amino-b-CD used by Lelievre et al [43], besides polycationic derivatives proposed to obtain a wider separation window for acidic racemates [44], have been used. However, the role of electrostatic interactions in the recognition process and in the complex formation is a matter of discussion [45±47, 25,26,42].…”

“…However, the role of electrostatic interactions in the recognition process and in the complex formation is a matter of discussion [45±47, 25,26,42].…”

Chiral Separation of α-Amino Acid Derivatives by Capillary Electrophoresis Using 6-Amino-6-deoxy-ß-cyclodextrin and Its N-Hexyl Derivative as Chiral Selectors

“…On the other hand, only one report has been presented, as far as we know, on the effect of a CD having a positively charged group on the chiral separation of amino acids: CDs having an amino group have shown a high chiral separation ability for 2-hydroxy acids because of their stable complex formations. 10 In this paper we report on the chiral separations of N-(2,4-dinitrophenyl)(DNP)-and N-dansyl(DNS)-a-amino acids by CZE using 6-amino-6-deoxy-f3-cyclodextrin (ACD, Fig. l) and 6-deoxy-6-hexylamino-/3-cyclodextrin (HACD, Fig.…”