Use of chemical conversion for determination of nitrated aromatic hydrocarbons using femtosecond ionization mass spectrometry

Femtosecond ionization mass spectrometry for chromatographic detection

“…In fact, an actual sample containing NPAHs was injected into the GC with and without hydrazine monohydrate (H2NNH2•H2O) as a reducing reagent. From the two-dimensional GC-MS displays shown in Figure 19, some of the components disappeared/appeared as the result of the reaction, suggesting that NPAHs were converted into amino PAHs (APAHs) [48]. Thus, NPAHs, whose carcinogenicity is 10-100,000 times larger than the corresponding PAHs, can be identified without using standard chemicals.…”

Determination of nerve agent metabolites in human urine by femtosecond laser ionization mass spectrometry using 2-(bromomethyl)naphthalene as a derivatizing reagent

“…Femtosecond ionization mass spectrometry (FI/MS) is particularly interesting in the respect, since sub-femtogram detection limits for polycyclic aromatic hydrocarbons have been reported [15]. It is also noteworthy to mention that it has been utilized for the determination of persistent organic pollutants (POPs) such as dioxins and pesticides [16], carcinogenic compounds such as nitro polycyclic aromatic hydrocarbons [17], allergy substances in a fragrance [18], and explosives such as trinitrotoluene and triacetone triperoxide [19]. It should also be noted that, in most cases, a molecular ion can be observed through resonance-enhanced multiphoton ionization (REMPI), even for molecules with very short excited-state lifetimes, when an ultraviolet (UV) femtosecond laser is used as the ionization source.…”