Use of circulating microRNAs as biomarkers in critically ill polytrauma patients

Bedreag, Ovidiu Horea; Rogobete, Alexandru Florin; Dumache, Raluca; Sărăndan, Mirela; Cradigati, Alina Carmen; Păpurică, Marius; Craciunescu, Mihaela; Popa, Diana Mihaela; Luca, Loredana; Nartita, Radu; Săndesc, Dorel

doi:10.1016/j.bgm.2015.11.002

Cited by 8 publications

(10 citation statements)

References 57 publications

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“…Inside the cytoplasm, a new reaction, initiated by an RNAse III endonuclease called Dicer and by the RNA binding protein (TRBP), takes place, which leads to the formation of the final microRNA species [17,20,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88]. The last step involves coupling the RNA-induced silencing complex (RISC) [18,78,79,80,81,82,83,84,85,86,87,88,89,90,91]. The final molecular species is then transported outside the cell through different mechanisms and in various forms, such as ribonucleoprotein complexes, microvesicles, exosomes, and high-density lipoproteins (Figure 1) [14].…”

Section: Biochemical and Biosynthesis Aspects Of Micrornasmentioning

confidence: 99%

“…MicroRNAs have been proposed as possible biomarkers because of the research evidence that shows that changes in a range of cellular microRNAs correlate with various pathophysiological conditions, including inflammation, oxidative stress, sepsis diabetes and different types of cancer [33,34,35,36,37,38,39,40,41,42,43,44,45,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93]. These molecules have also been known for their low complexity, simple detection and amplification, tissue-restricted expression profiles, and sequence conservation between human and model organisms [94,95,96,97,98].…”

Section: Microrna Identification From Different Body Fluidsmentioning

confidence: 99%

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MicroRNA Expression is Associated with Sepsis Disorders in Critically Ill Polytrauma Patients

Rogobete

Săndesc

Bedreag

et al. 2018

Cells

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A critically ill polytrauma patient is one of the most complex cases to be admitted to the intensive care unit, due to both the primary traumatic complications and the secondary post-traumatic interactions. From a molecular, genetic, and epigenetic point of view, numerous biochemical interactions are responsible for the deterioration of the clinical status of a patient, and increased mortality rates. From a molecular viewpoint, microRNAs are one of the most complex macromolecular systems due to the numerous modular reactions and interactions that they are involved in. Regarding the expression and activity of microRNAs in sepsis, their usefulness has reached new levels of significance. MicroRNAs can be used both as an early biomarker for sepsis, and as a therapeutic target because of their ability to block the complex reactions involved in the initiation, maintenance, and augmentation of the clinical status.

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Section: Biochemical and Biosynthesis Aspects Of Micrornasmentioning

confidence: 99%

Section: Microrna Identification From Different Body Fluidsmentioning

confidence: 99%

MicroRNA Expression is Associated with Sepsis Disorders in Critically Ill Polytrauma Patients

Rogobete

Săndesc

Bedreag

et al. 2018

Cells

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“…Up-regulation: NMP22, FGFR3, BTA, ImmunoCyt/uCyt1, SOX1, a specific LINE-1 element, IL-1, IRAK3, OTX1, ONECUT2, OSR1, HDAC-1/2 overexpression, KLF4, survivin (BIRC5 or EPR-1), AURKA, NLR, pRB, p21, -27, HRAS, PI3K, CD44v6, VEGFR1/2, HYAL-1, CA-IX, PFKFB4; Micro-RNAs (miR-96, miR-138, miR-126, miR-182, miR-143, miR-222, miR-21, miR-133b, miR-518c-5p, miR-452, miR-129, miR-99a, miR-100, miR-141, miR-639); Downregulation: Micro-RNAs (miR-200c, miR-99a, miR-100, miR-29c) (Bedreag et al, 2015;Lucca et al, 2015).…”

Section: Bladder Cancermentioning

confidence: 99%

“…Micro-RNAs (Up-regulation: miR-16, miR-92a, miR-103, miR-107, miR-197, miR-34b, miR-328, miR-485-3p, miR-92b, miR-636, miR-640, miR-766, miR-885-5p) (Bedreag et al, 2015); PSA (Buchbinder and Flaherty, 2016).…”

Section: Prostate Cancermentioning

confidence: 99%

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Dictatorial streaming of biomarkers in some diseases

Islam

Riaz

Ferdous

et al. 2016

IJAPSR

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ABSTRACT:The term "biomarker" is used from 1980. Nowadays, diagnosis/prognosis and research in medical science are more concerned with the discovery and utilization of a number of biomarkers. The information in the library of biomarkers is rising day by day as their major concerns relate diseases, pathogenicity or pharmacology in a variety of hosts. Taking into account, we summarize a number of biomarkers in a number of diseases in human. It includes the name and their up-and/or down expressions in those situations. However, no description was plugged with the individual fact.

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microRNAs Expression as Novel Genetic Biomarker for Early Prediction and Continuous Monitoring in Pulmonary Cancer

et al. 2017

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One of the main causes of death in the world is lung cancer. According to the World Health Organization, the annual incidence of lung cancer increases significantly. Moreover, lung cancer accounts for one of the highest mortality rates, mainly due to late detection. Numerous studies have been conducted in order to identify new biomarkers for early diagnosis and for monitoring and evaluation of lung cancer stages. An ideal biomarker candidate is represented by the analysis of microRNAs expression. In this paper, we want to summarize microRNAs expressions in lung cancer. We also want to present the expression of microRNAs depending on the evolution of lung cancer. For this study, we analyzed the studies available in scientific databases, such as PubMed and Scopus. The studies were selected using the search keywords "microRNAs expression," "lung cancer," and "genetic biomarkers." The most significant articles were selected for the study, following rigorous analysis. To evaluate and monitor lung cancer, the expression of microRNAs may be used successfully due to increased specificity and selectivity. However, further studies are needed on the assignment and validation of microRNAs for each type of lung cancer, respectively, for each stage of evolution.

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Use of circulating microRNAs as biomarkers in critically ill polytrauma patients

Cited by 8 publications

References 57 publications

MicroRNA Expression is Associated with Sepsis Disorders in Critically Ill Polytrauma Patients

MicroRNA Expression is Associated with Sepsis Disorders in Critically Ill Polytrauma Patients

Dictatorial streaming of biomarkers in some diseases

microRNAs Expression as Novel Genetic Biomarker for Early Prediction and Continuous Monitoring in Pulmonary Cancer

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