Use of colour Doppler imaging in ocular blood flow research

Stalmans, Ingeborg; Vandewalle, Evelien; Anderson, Douglas R.; Costa, Vital Paulino; Frenkel, Ronald E. P.; Garhöfer, Gerhard; Grunwald, Juan E.; Gugleta, Konstantin; Harris, Alon; Hudson, Christopher; Janulevičienė, Ingrida; Kagemann, Larry; Kergoat, Hélène; Lovasik, John V.; Lanzl, Ines; Martínez, Antonio; Nguyen, Quan Dong; Plange, Niklas; Reitsamer, Herbert A.; Sehi, Mitra; Siesky, Brent; Zeitz, Oliver; Orgül, Selim; Schmetterer, Leopold

doi:10.1111/j.1755-3768.2011.02178.x

Cited by 132 publications

(156 citation statements)

References 156 publications

(279 reference statements)

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“…Before the study the intra-observer concordance was tested and all the examiners showed an acceptable degree of reproducibility with both devices [12]. Examiners conducted the examination in accordance with the methods reported by previous investigations [7].…”

Section: Data Collectionmentioning

confidence: 99%

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Inter-device reproducibility of retrobulbar blood flow velocity measurements in healthy subjects using color Doppler imaging

C.¹,

Cutolo

Dellafiore

et al. 2016

J Ultrasound

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Purpose To evaluate the inter-device reproducibility of retrobulbar blood flow measurements obtained by two commercially available CDI (color Doppler imaging) devices. Methods The right eyes of 10 healthy volunteers were investigated. Four examiners, namely two ophthalmologists and two radiologists, performed CDI examination of the ophthalmic artery, central retinal artery and temporal short posterior ciliary arteries using both CDI devices: ESAOTE MYLAB TM and SIEMENS ANTARES STEL-LAR PLUS TM . The peak systolic velocity (PSV), the enddiastolic velocity (EDV) and the resulting resistivity index (RI) were averaged for 3 cardiac cycles. To evaluate the reproducibility between both device measurements, the Lin's concordance correlation coefficient (CCC) was used. CCC can be expressed as the product of Pearson's r (the measure of precision) and C_b (the measure of accuracy). Results Results show that the inter-device reproducibility for CDI measurements is not acceptable since a poor degree of overall concordance (0.15\CCC\0.37) was obtained: accuracy was high (C_b [ 0.71) but overall precision low (0.18\Pearson's r\0.47). Ophthalmologists and radiologists obtained similar results. Conclusions To evaluate the causal role of blood flow abnormalities in glaucoma, CDI analysis using different devices seems unreliable. CDI inter-device reproducibility seems unrelated to medical speciality of the examiners. However, to improve present results, the use of similar probes and standardized CDI instrument settings as well as a CDI images analysis by a single grader, might possibly improve the inter-device reproducibility when testing the retrobulbar blood flow velocity.Keywords Blood flow velocity Á Doppler ultrasound imaging Á Glaucoma Á Healthy volunteers Á Reproducibility of results AbstractScopo Valutare la riproducibilità delle misurazioni delle velocità di flusso ematico nei vasi retrobulbari di volontari sani: le misurazioni sono state ottenute con due diverse strumentazioni ecografiche commercialmente disponibili. Materiali e Metodi Quattro operatori, due radiologi e due oculisti, hanno misurato le velocità di flusso nell'arteria oftalmica (AO), nell'arteria centrale della retina (ACR) e nelle arterie ciliari posteriori brevi (ACPB) in 10 occhi di volontari sani utilizzando due ecografi: ESAOTE MYLAB TM and SIEMENS ANTARES STELLAR PLUS TM . Sono state calcolate le medie di 3 cicli cardiaci dei parametri di flusso PSV (velocità di picco sistolico), EDV (velocità di fine diastole) e IR (indice di resistività). Per valutare la riproducibilità delle misure effettuate con le due strumentazioni è stato calcolato il coefficiente di correlazione di Lin (CCC). Il CCC può essere espresso come il prodotto del coefficiente di Pearson's r (misura della precisione) e C_b (misura dell'accuratezza). Risultati I risultati mostrano che la riproducibilità delle misurazioni tra due ecografi non è accettabile dal momento che è stato ottenuto uno scarso grado di concordanza (0.15\CCC\0.37): il grado di accuratezza è alto (C_b [ 0....

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Section: Data Collectionmentioning

confidence: 99%

“…Color Doppler imaging (CDI) is a non-invasive technique used to evaluate blood flow of the eye, not affected by poor ocular media, with acceptable intra-observer reproducibility [7] which shows perfusion abnormalities in POAG patients [8,9]. Despite this, it is difficult to establish the causal role of ischemia in glaucoma.…”

Section: Introductionmentioning

confidence: 99%

Inter-device reproducibility of retrobulbar blood flow velocity measurements in healthy subjects using color Doppler imaging

C.¹,

Cutolo

Dellafiore

et al. 2016

J Ultrasound

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“…6,19,[28][29][30] Doppler OCT is a promising approach for measuring retinal blood flow. If absolute blood flow is to be measured, the angle ambiguity of the Doppler techniques has to be resolved.…”

Section: Discussionmentioning

confidence: 99%

“…Color Doppler imaging measures blood velocities in retrobulbar vessels, but no information on vessel diameters is available. 6 Laser Doppler flowmetry and speckle flowgraphy can be used to assess choroidal and optic nerve blood flow in relative units. 7,8 For several years, the only technique providing information about retinal blood flow was the combined measurement of retinal blood velocity via laser Doppler velocimetry (LDV) and of vessel diameters using fundus photographs.…”

Section: Introductionmentioning

confidence: 99%

Measurement of retinal blood flow in the rat by combining Doppler Fourier-domain optical coherence tomography with fundus imaging

et al. 2014

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Abstract. A wide variety of ocular diseases are associated with abnormalities in ocular circulation. As such, there is considerable interest in techniques for quantifying retinal blood flow, among which Doppler optical coherence tomography (OCT) may be the most promising. We present an approach to measure retinal blood flow in the rat using a new optical system that combines the measurement of blood flow velocities via Doppler Fourier-domain optical coherence tomography and the measurement of vessel diameters using a fundus camera-based technique. Relying on fundus images for extraction of retinal vessel diameters instead of OCT images improves the reliability of the technique. The system was operated with an 841-nm superluminescent diode and a charge-coupled device camera that could be operated at a line rate of 20 kHz. We show that the system is capable of quantifying the response of 100% oxygen breathing on the retinal blood flow. In six rats, we observed a decrease in retinal vessel diameters of 13.2% and a decrease in retinal blood velocity of 42.6%, leading to a decrease in retinal blood flow of 56.7%. Furthermore, in four rats, the response of retinal blood flow during stimulation with diffuse flicker light was assessed. Retinal vessel diameter and blood velocity increased by 3.4% and 28.1%, respectively, leading to a relative increase in blood flow of 36.2%. The presented technique shows much promise to quantify early changes in retinal blood flow during provocation with various stimuli in rodent models of ocular diseases in rats. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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“…К современным методам исследования глазного кровотока относятся [10][11][12][13][14][15][16] цветовое допплеров-ское картирование (ЦДК), сканирующая лазерная допплеровская флоуметрия, определение диаметра ретинальных сосудов и их ветвей на анализаторе со-судов сетчатки, лазерная спекл-флоуграфия, позво-ляющая измерить диаметр, цифровая сканирующая лазерная офтальмоскопическая ангиография, рети-нальная оксиметрия и оптическая когерентная то-мография (ОКТ) с функцией допплера (DOCT). Подробное описание указанных методов приведено нами ранее [17].…”

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Optical coherence tomography angiography in glaucoma diagnosis

Kurysheva

Маслова

2016

Vestn. oftal'mol.

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Оптическая когерентная томография с функцией ангиографии в диагностике глаукомы Н.И. курыШеВА, е.В. МАСлоВА ФГБоу ДПо «Институт повышения квалификации» ФМБА, ул. Гамалеи, 15, Москва, 123098, российская Федерация Данные литературы свидетельствуют o вовлечении сосудистой дисфункции в патогенез глаукомной оптиконейропатии. Это делает обоснованным поиск новых методов визуализации для ранней диагностики и мониторинга глаукомы, направленных на изучение перфузии сетчатки, зрительного нерва и хориоидеи. Появившийся недавно метод оптической когерентной томографии с функцией ангиографии (окТ-А), основанный на измерении степени декорреляции последовательных по времени B-сканов (split-spectrum amplitude-decorrelation angiography, SSADA), позволяет измерить кровоток сетчатки и хориоидеи как в перипапиллярной, так и макулярной зонах. результаты первых исследований методом окТ-А показали снижение кровотока при глаукоме. Периметрические индексы лучше коррелируют с индексом перипапиллярного кровотока, чем с морфометрическими показателями диска зрительного нерва (ДЗН) и перипапиллярной сетчатки. окТ-А имеет большие перспективы в исследовании кровотока ДЗН при проведении физиологических тестов, что важно для понимания патогенеза глаукомы. According to literature data, vascular dysfunction may well contribute to the development of glaucomatous optic neuropathy, which makes it reasonable to search for new imaging techniques capable of early diagnosis and monitoring of glaucoma through assessment of retinal, optic nerve head (ONH), and choroidal perfusion. Optical coherence tomography angiography (OCTA), a recently introduced method based on the split-spectrum amplitude-decorrelation angiography (SSADA) algorithm, enables evaluation of both retinal and choroidal blood flow in peripapillary and macular areas. The first studies involving OCTA have revealed a decrease in retinal blood flow in glaucoma. It has also been shown that visual field indices correlate better with the peripapillary flow index than with morphometric parameters of the optic nerve head (ONH) and peripapillary retina. OCT angiography has great potential for ONH blood flow assessment during physiological tests, which is an important step towards understanding pathogenesis of glaucoma.

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Use of colour Doppler imaging in ocular blood flow research

Cited by 132 publications

References 156 publications

Inter-device reproducibility of retrobulbar blood flow velocity measurements in healthy subjects using color Doppler imaging

Inter-device reproducibility of retrobulbar blood flow velocity measurements in healthy subjects using color Doppler imaging

Measurement of retinal blood flow in the rat by combining Doppler Fourier-domain optical coherence tomography with fundus imaging

Optical coherence tomography angiography in glaucoma diagnosis

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