Use of Contractubex® (Allantoin, Heparin, Extractum Cepae) to Prevent Scar Formation in The Rabbits to Which Primary Closure has been Applied After Urethrotomy

Abstract

The scar tissue occurring in operating area after the repair of hypospadias which is one of the common congenital anomalies of male children has part in formation of post-operative complications. Many surgical techniques and materials have been used to reduce complications. The purpose of this study is to research the effects of contractubex ® (allantoin, heparin, extractum cepae [AHEC]) gel on development of scar in the area repaired after urethrotomy. In the study, 45 male White New Zealand rabbits were used. The rabbits were divided into three groups randomly. Group 1(K): The group to which urethrotomy and primary closure were applied Group 2(A): The group to which urethrotomy, primary closure + 15-day AHEC were applied Group 3(B): The group to which urethrotomy, primary closure + 30-day AHEC were applied Urethras of the rabbits in the groups were calibrated with angiocath (24 Fr) once a day for 30 days. Along with calibration, AHEC was applied to the urethras of the rabbits in 2 nd group for 15 days and urethras of the rabbits in the 3 rd group for 30 days. To evaluate scar tissue, macroscopic and histopathological evaluations were carried out. Although inflammation was much more in the groups to which AHEC was applied, fibrosis was determine d to be less. It is thought that the application of AHEC may be effective in reducing scar formation after operation.

Effect of Extractum Cepae, Heparin Sodium and Allantoin Combination (Contractubex) on Adhesion and Fibrosis After Neck Surgery (Thyroidectomy) in Rats

“…In our study, it was observed that fibrosis developed less in the drug group than in the control group. Ayengin and Kilic [ 28 ] showed that contractubex reduced the development of fibrosis in their experimental hypospadias model, but the inflammation detected histopathologically was higher than the control.…”