Use of cryobiopsy in dermatological practice

Pasquali, Paola; Freites-Martínez, Azael; Fortuño-Mar, Angeles

doi:10.1016/j.jaad.2014.10.005

Cited by 5 publications

(4 citation statements)

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“…1 Several other therapies have been proposed, including cyclosporine, 13 intralesional corticosteroids, 14 and cryosurgery. 15 In the present patients, surgical excision was not a suitable option owing to the morbidity associated with excision of a large number of simultaneously erupting lesions. Systemic agents such as oral retinoid therapy posed a challenge owing to potential adverse effects, tolerability, and potential interactions in the setting of patients with metastatic cancer undergoing immunotherapies.…”

Section: Key Pointsmentioning

confidence: 72%

“…1 Several other therapies have been proposed, including cyclosporine, 13 intralesional corticosteroids, 14 and cryosurgery. 15 …”

Section: Discussionmentioning

confidence: 99%

“…For eruptive KAs, especially those associated with syndromes, systemic acitretin or other retinoids are first-line therapy, either as monotherapy or combined with surgery . Several other therapies have been proposed, including cyclosporine, intralesional corticosteroids, and cryosurgery …”

Section: Discussionmentioning

confidence: 99%

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Eruptive Keratoacanthomas Associated With Pembrolizumab Therapy

et al. 2017

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IMPORTANCETo our knowledge, there have been no previous reports of eruptive keratoacanthomas (KAs) in patients receiving pembrolizumab.OBJECTIVE To report the cases of 3 consecutive patients with pembrolizumab-induced eruptive KAs and their management. DESIGN, SETTING, AND PARTICIPANTS Case report study of 3 patients from 2 centers with pembrolizumab-treated cancer who all developed eruptive KAs. INTERVENTIONS All 3 patients had AK treatment with clobetasol ointment and intralesional triamcinolone; 2 patients also underwent open superficial cryosurgery.RESULTS Three consecutive patients with cancer, 2 men and 1 woman (median age, 83 years; range 77-91 years), experienced pembrolizumab-associated eruptive KAs. All patients presented with a sudden onset of multiple lesions on sun-exposed areas of their extremities after a median of 13 months (range, 4-18 months) of pembrolizumab therapy. On lesional biopsy, a lichenoid infiltrate was observed in the underlying dermis, predominantly composed of CD3 + T cells, scattered CD20 + B cells, and relatively few PD-1 + (programmed cell death 1-positive) T cells, an immunophenotypic pattern also observed in other cases of anti-PD-1-induced lichenoid dermatitis. Patients were treated with clobetasol ointment and intralesional triamcinolone, alone or in combination with open superficial cryosurgery. All KAs resolved in all patients, and no new lesions occurred during close follow-up. Pembrolizumab treatment was continued without disruption in all 3 cases, and all patients had complete responses of their primary cancers.CONCLUSIONS AND RELEVANCE Pembrolizumab is used in advanced melanoma, advanced non-small-cell lung cancer, and in head and neck cancer. A variety of dermatologic immune-related adverse events including maculopapular eruption, lichenoid reactions, pruritus, and vitiligo have been described. This case series demonstrates that pembrolizumab therapy may also be associated with eruptive KAs with characteristic dermal inflammation, which improved with corticosteroid treatment (topical and intralesional) alone or in combination with cryosurgery, allowing patients to continue therapy with pembrolizumab.

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Section: Key Pointsmentioning

confidence: 72%

“…1 Several other therapies have been proposed, including cyclosporine, 13 intralesional corticosteroids, 14 and cryosurgery. 15 …”

Section: Discussionmentioning

confidence: 99%

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Eruptive Keratoacanthomas Associated With Pembrolizumab Therapy

et al. 2017

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“…The National Comprehensive Cancer Network guideline recommends wide surgical excision or Mohs micrographic surgery for the treatment of local, low-risk SCC [ 1 ]. Alternative treatments for patients refusing surgery or for neoplasms arising in areas where surgery is difficult to perform may be required; these include cryosurgery, intralesional application of 5-fluorouracil, methotrexate, or interferon α-2a, radiation therapy, and systemic oral retinoids [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

Successful Treatment of a Keratoacanthoma with Electrochemotherapy: A Case Report

Pasquali

Spugnini²,

Baldi

2018

Dermatol Ther (Heidelb)

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IntroductionFew studies have evaluated the efficacy of intralesional bleomycin injection combined with electroporation for the treatment of cutaneous tumors. However, the phenomenon that electroporation can enhance the cytotoxicity of bleomycin in vivo by 300–700 fold has been intensely investigated.Case PresentationKeratoacanthoma in an 86-year-old patient was treated with intralesional bleomycin combined with electroporation. Treatment consisted of local application of shorty and intense electric pulses followed by local injection of bleomycin. Electroporation was always well tolerated by the patient, with no significant complaints, and the tumor had completely regressed by day 71 of the follow-up.ConclusionThe results suggest that intralesional bleomycin injection combined with electroporation could represent a valid alternative therapeutic approach for the treatment of keratoacanthomas.

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