Use of Cucurbit [6] Uril as a Modifier in the Electrochemical Determination of Antitumor Platinum (II) Complex: <i>Trans</i>-[PtCl<sub>2</sub>(Dimethylamine) (Isopropylamine)]. Application to Biological Samples

Abstract

A square wave voltammetry (DPV) method for trans-Pt[Cl 2 (Dimethylamine)(isopropylamine)] determination is developed. To this end, all the chemical and instrumental variables affecting the determination of trans-Pt[Cl 2 (Dimethylamine) (isopropylamine)] are optimized. From studies of the mechanisms governing the electrochemical response of transPt[Cl 2 (Dimethylamine)(isopropylamine)], it was concluded that it was an electrochemically reversible system with an adsorptive oxidation phenomenon. Under optimal conditions, the variation of analytical signal (Ip) with transPt[Cl 2 (Dimethylamine)(isopropylamine)] concentration was linear in the 0.05 µg·mL -1 to 10 µg·mL -1 range, with a LOD 91 µg·mL -1 of and a LOQ of 303 µg·mL -1 , a RSD 1.10% and Er 0.72%. The optimized method was applied to the determination of trans-Pt[Cl 2 (Dimethylamine)(isopropylamine)] in biological fluids, in human urine and synthetic urine.

Locked and Loaded: Ruthenium(II)-Capped Cucurbit[n]uril-Based Rotaxanes with Antimetastatic Properties

“…The pursuit of better metallodrugs has led to a wide range of coordination compounds based on Pt­(II), Pt­(IV), , and other , metals (e.g., Ru and Au). Several strategies − for improving drug delivery, including encapsulating Pt complexes in macrocyclic carriers such as cucurbiturils (CB) or cyclodextrins, have been investigated. Two examples of related platinum host–guest complexes are depicted in Figure : a neutral oxaliplatin@CB7 complex , (Figure A) and a trans -[{PtCl­(NH 3 ) 2 }-μ-4,4′-dipyrazolylmethane]@CB7 complex (Figure B) …”

Supramolecular Coronation of Platinum(II) Complexes by Macrocycles: Structure, Relativistic DFT Calculations, and Biological Effects

“…The unconventional design of novel Pt-based metallodrugs has split in several directions. − Some of these lead to multinuclear complexes that exhibit novel modes of action toward cisplatin-resistant cell lines, others focus on more efficient delivery and targeting . Both the efficiency of delivery and the stability of Pt drugs are enhanced by using carrier systems, which provide (to some extent) control over the drug release and reduce side effects. , Encapsulation within a molecular carrier, such as cyclodextrin (CD) or cucurbituril (CB), may also increase the drug solubility and efficacy. , Although CD is reported to facilitate the intracellular transport of its guest, − host–guest complexes with CB cross the cell membranes. , Two examples of encapsulated Pt complexes are shown in Figure .…”