Use of cyanoacrylate adhesives in general surgery

Abstract

This paper presents a review of the use of cyanoacrylate adhesives (CA) in general surgery and digestive surgery, studies the mechanisms of action and interactions of CAs in adherent tissues, and compiles data on the latest experimental and clinical applications. More than seven million traumatic injuries are estimated to occur every year, and between 26 and 90 million surgical procedures using different techniques are performed to close the resulting wounds. Traditional methods not only are both useful and effective, but also have some drawbacks. This review covers a considerable number of surgical procedures for which CAs had satisfactory results. The adhesive facilitated the healing of very diverse tissues, such as solid organs, vascular tissue or the abdominal wall. In other cases, no significant differences were found when CA was compared to traditional methods, with the adhesive standing out as a simple and reliable solution. The number of procedures in which CA was detrimental was very low. This review also collects and describes these. In conclusion, the surgical fields and procedures in which CA was successfully used are highly diverse. This review will allow physicians to determine which techniques were first used experimentally, but finally settled in clinical practice as feasible alternatives to standard treatments.

Multifunctional nanoparticles as a tissue adhesive and an injectable marker for image-guided procedures

“…One of the major hurdles for intracorporeal use of CA-Lp is its severe toxicity and the inflammatory reactions caused by the by-products of CA-Lp such as formaldehyde55051. Recent reports, however, have shown that both SiO 2 and TaO x nanoparticles are highly biocompatible2327415253.…”

“…Hence, their clinical demands have grown significantly, and consequently, a number of tissue adhesives based on proteins and synthetic polymers including fibrin, gelatin, polyurethanes, and polyethylene glycol have been developed to accommodate various surgical situations5678910. The convenience of tissue adhesives is particularly noticeable in minimally invasive procedures and image-guided surgeries because they are very effective for treating a confined region of interest that is inaccessible with other wound closure methods, which can greatly reduce postoperative complications.…”

Effect of Allogeneic Platelet Lysate and Cyanoacrylate Tissue Glue on the Fibrovascularization of the Porous Polyethylene Implant

“…There are several studies which report that cyanoacrylate tissue adhesives do not interfere with the wound healingmechanisms. [41][42][43] They also do not interfere with the usual tissue staining methods which might affect histopathological assessment. 44 CTG was found to have acceptable compatibility with blood cells (platelets and leukocytes) and plasma components.…”

Radical Polymerization of Alkyl 2-Cyanoacrylates

“…Longer-chain CAs, such as n -butyl and 2-octyl 2-cyanoacrylate (Figure 1), have found utility as surgical suture replacements for skin and tissue adhesives [7,8,9,10]. Poly(CAs) have gained recognition for numerous biomedical applications due to their favorable biocompatibility, biodegradability, and low toxicity.…”

“…The general monomer chemistry, synthesis, modes of polymerization, and the physical characteristics of the resulting polymers, along with several toxicological evaluations, have been detailed in a number of reviews [1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,20,21,22]. In this review, after a general overview of reactivity and properties, the focus is the radical polymerization of CAs, with the advantages over the more facile anionic pathway clearly outlined.…”