Use of dual-energy X-ray absorptiometry (DEXA) to follow mineral content changes in small ceramic implants in rats

Mosheiff, Rami; Klein, Benjamin Y.; Leichter, Isaac; Chaimsky, Gershon; Nyska, A.; Peyser, Amos; Segal, David

doi:10.1016/0142-9612(92)90167-m

Cited by 21 publications

(4 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A special standardization technic was employed: an area of exactly the same size and location was assessed in each animal [8]. The mean of three repeated measurements was used.…”

Section: Bone Density Studiesmentioning

confidence: 99%

Prolonged Magnesium Deficiency Causes Osteoporosis in the Rat

Stendig-Lindberg

Koeller

Bauer

et al. 2004

Journal of the American College of Nutrition

View full text Add to dashboard Cite

show abstract

“…A special standardization technic was employed: an area of exactly the same size and location was assessed in each animal [8]. The mean of three repeated measurements was used.…”

Section: Bone Density Studiesmentioning

confidence: 99%

Prolonged Magnesium Deficiency Causes Osteoporosis in the Rat

Stendig-Lindberg

Koeller

Bauer

et al. 2004

Journal of the American College of Nutrition

View full text Add to dashboard Cite

show abstract

“…88 DEXA has been demonstrated to measure accurately the BMC and BMD of very small areas of interest, 89 such as in rat bone. [90][91][92] Like SPA, DEXA has been commonly used to evaluate BMC/BMD (even for small bones), and mechanical properties of normal bone, 84 healing bone, 64,85,93 and osteoporotic bone 92,94,95 in animal models.…”

Section: Single-photon Single X-ray and Dual-energy Absorptiometrymentioning

confidence: 99%

Methods of Evaluation for Bone Dimensions, Densities, Contents, Morphology, and Structures

An¹,

Barfield²,

Knēts³

1999

Mechanical Testing of Bone and the Bone-Implant Interface

View full text Add to dashboard Cite

“…Mosheiff et al (16) demonstrated that D X A can be used to follow changes in the bone mineral density of small ceramic implants in rat bones. Markel and Bogdanske (15) bone mineral density of regions of interest 2.5 mm wide can be measured in a canine tibia1 ostectomy model.…”

mentioning

confidence: 99%

Atrophic nonunion can be predicted with dual energy x‐ray absorptiometry in a canine ostectomy model

Markel

Bogdanske

Xiang

et al. 1995

Journal Orthopaedic Research

View full text Add to dashboard Cite

This study demonstrated that dual energy x-ray absorptiometry can be used to distinguish between normal union and atrophic nonunion, with high sensitivity and high negative predictive value, by 8 weeks after surgery in a canine model. Eighteen adult mixed-breed dogs were divided into two equal groups: normal union and atrophic nonunion. In the normal union group, a 5 mm mid-diaphyseal transverse ostectomy was performed in the right tibia, and the bone was stabilized with a unilateral external fixator. In the atrophic nonunion group, a 5 mm mid-diaphyseal ostectomy was performed; the distal 1.5 cm of the bone ends, including the periosteum, were frozen twice to -20 degrees C using liquid nitrogen and thawed slowly twice; and the bone was stabilized with a unilateral external fixator. The members of the research team were blinded to the group assignments until after all dogs were killed and all data were acquired. Radiography and dual energy x-ray absorptiometry of both tibiae were performed at weeks 1, 2, 3, 4, 6, 8, 10, 12, 14, and 16 after surgery. All dogs were killed at 16 weeks, and the torsional stiffness and maximum torque of both tibiae of five dogs in each group were determined. Mechanically, the tibiae in the normal union group had significantly higher maximum torque (43-fold higher) and torsional stiffness (86-fold higher) than the tibiae in the atrophic nonunion group. The sensitivity and negative predictive value of dual energy x-ray absorptiometry for predicting nonunion were 100% by 8 weeks after surgery. The specificity and positive predictive value reached 78 and 82%, respectively, by 16 weeks. Radiographic scores were significantly higher for the union group than for the nonunion group beginning at 2 weeks after surgery. The earliest time after surgery that radiography classified an ostectomy as a nonunion was significantly later (4.6 +/- 1.2 weeks) than for dual energy x-ray absorptiometry (2.6 +/- 1.4 weeks). Before these results can be extrapolated to human applications, further animal studies must be performed to evaluate clinically or experimentally induced fractures, or both, rather than the well defined ostectomies that were performed in this study.

show abstract

Use of dual-energy X-ray absorptiometry (DEXA) to follow mineral content changes in small ceramic implants in rats

Cited by 21 publications

References 12 publications

Prolonged Magnesium Deficiency Causes Osteoporosis in the Rat

Prolonged Magnesium Deficiency Causes Osteoporosis in the Rat

Methods of Evaluation for Bone Dimensions, Densities, Contents, Morphology, and Structures

Atrophic nonunion can be predicted with dual energy x‐ray absorptiometry in a canine ostectomy model

Contact Info

Product

Resources

About