Use of FDG-microPET for detection of small nodules in a rabbit model of pulmonary metastatic cancer

Abstract

By FDG-microPET, it is possible to evaluate tumors larger than 2 mm in diameter and to follow the growth of individual tumors. Our results also suggest that the rabbit model of VX-2 pulmonary metastasis is a stable experimental model for evaluation using FDG. Monitoring of the therapeutic effects of anticancer drugs and radiation therapy could be tried by using this model and microPET.

Animal PET for Thioacetamide-Induced Rat Cholangiocarcinoma: A Novel and Reliable Platform

“…Firstly, animal PET with FDG may fail to show enhanced accumulation in tumor tissue, as previously reported in human PET studies [27]. Second, although accuracy in detecting tumors larger than 2 mm is high, animal PET may miss approximately 35% of tumors smaller than 1 mm [28]. According to our autoradiography results, our animal PET scanner cannot detect CCA that are less than 2 mm in size.…”

In vivo bioluminescence imaging for early detection and monitoring of disease progression in a murine model of neuroblastoma

“…Although techniques such as CT [1], MRI [2,3], and PET scanning [4] have become available for small animal imaging, BLI has the advantage of requiring very little operational expertise. In addition, a large number of animals can be analyzed in a relatively short period of time because image acquisition is usually on the order of seconds to a few minutes, and multiple animals can be imaged simultaneously.…”

“…To help overcome these limitations, several imaging modalities commonly used in humans have been adapted for small animals. Computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET), ultrasonography (USG), and plain radiographs have all been used to longitudinally evaluate tumor growth in research animals [1][2][3][4][5][6]. Although CT, MRI, and PET imaging can detect minimal disease with high-quality anatomical detail, they require a high degree of operational expertise, can be laborintensive, and are often cost prohibitive.…”

Comparison of dynamic FDG-microPET study in a rabbit turpentine-induced inflammatory model and in a rabbit VX2 tumor model

“…[13][14][15] As for the animal studies using microPET on inflammatory and tumor lesions, some studies have reported changes in FDG uptake over time in tumor lesions only 16 and FDG uptake at specific time points in inflammation lesions 17 or comparison between inflammatory and tumor lesions.18 To our knowledge, no comparative study of FDG uptake in tumors and inflammation lesions has been conducted using dynamic FDGmicroPET.…”