Use of Fenuqreek seed powder in the management of non-insulin dependent diabetes mellitus

Sharma, Rakesh; Sarkar, A.; Hazara, Dipak Kumar; Mishra, B.; Singh, Joginder; Sharma, Sushma; Maheshwari, B. B.; Maheshwari, Piyush

doi:10.1016/0271-5317(96)00141-8

Cited by 98 publications

(56 citation statements)

References 19 publications

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“…In these series of trials, whole raw seeds, extracted seed powder, gum isolate of seeds, and cooked whole seeds seemed to decrease postprandial glucose levels, whereas degummed seeds and cooked leaves did not (79). Other open-label prospective cohort studies have followed patients on fenugreek for up to 6 months with reported benefits in glycemic control (79,(81)(82)(83)(84). No adverse effects were reported in these trials.…”

Section: Trigonella Foenum Graecummentioning

confidence: 98%

Systematic Review of Herbs and Dietary Supplements for Glycemic Control in Diabetes

et al. 2003

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OBJECTIVE -To conduct a systematic review of the published literature on the efficacy and safety of herbal therapies and vitamin/mineral supplements for glucose control in patients with diabetes.RESEARCH DESIGN AND METHODS -We conducted an electronic literature search of MEDLINE, OLDMEDLINE, Cochrane Library Database, and HealthSTAR, from database inception to May 2002, in addition to performing hand searches and consulting with experts in the field. Available clinical studies published in the English language that used human participants and examined glycemic control were included. Data were extracted in a standardized manner, and two independent investigators assessed methodological quality of randomized controlled trials using the Jadad scale.RESULTS -A total of 108 trials examining 36 herbs (single or in combination) and 9 vitamin/ mineral supplements, involving 4,565 patients with diabetes or impaired glucose tolerance, met the inclusion criteria and were analyzed. There were 58 controlled clinical trials involving individuals with diabetes or impaired glucose tolerance (42 randomized and 16 nonrandomized trials). Most studies involved patients with type 2 diabetes. Heterogeneity and the small number of studies per supplement precluded formal meta-analyses. Of these 58 trials, the direction of the evidence for improved glucose control was positive in 76% (44 of 58). Very few adverse effects were reported.CONCLUSIONS -There is still insufficient evidence to draw definitive conclusions about the efficacy of individual herbs and supplements for diabetes; however, they appear to be generally safe. The available data suggest that several supplements may warrant further study. The best evidence for efficacy from adequately designed randomized controlled trials (RCTs) is available for Coccinia indica and American ginseng. Chromium has been the most widely studied supplement. Other supplements with positive preliminary results include Gymnema sylvestre, Aloe vera, vanadium, Momordica charantia, and nopal. Diabetes Care 26:1277-1294, 2003D iabetes is a predominant public health concern, affecting ϳ16 million persons in the U.S. The disease causes substantial morbidity, mortality, and long-term complications and remains an important risk factor for cardiovascular disease. With increasing rates of childhood and adult obesity, diabetes is likely to become even more prevalent over the coming decade (1).In response to the increasing use of complementary and alternative medicine (CAM) among the general public (2,3), the American Diabetes Association issued a Position Statement in 2001 on "Unproven Therapies" that encouraged health care providers to ask their patients about alternative therapies and practices, evaluate each therapy's effectiveness, be cognizant of any potential harm to patients, and acknowledge circumstances in which new and innovative diagnostic or therapeutic measures might be provided to patients (4).Recently, two national surveys have examined CAM use among those with diabetes. One study, using 1996 Me...

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Section: Trigonella Foenum Graecummentioning

confidence: 98%

Systematic Review of Herbs and Dietary Supplements for Glycemic Control in Diabetes

et al. 2003

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“…It has been found to decrease the serum glucose levels and also the postprandial insulin flow which aiding diabetic control [13]. Psyllium seeds from P. ovata and fenugreek seeds from T. foenum-graecum are also reported as an adjunct to dietary therapy in patients with type II diabetes, to reduce glucose and glycosylated hemoglobin [14,15]. Figure 1 showed that the retardation effect on glucose movement of the mucilages from P. ovata and T. foenum-graecum were lower degree than glucomannan.…”

Section: In Vitro Property Of Entrapping Glucosementioning

confidence: 99%

In Vitro Glucose Entrapment and Alpha-Glucosidase Inhibition of Mucilaginous Substances from Selected Thai Medicinal Plants

Palanuvej

2009

Sci. Pharm.

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As a continuous searching for anti-diabetic(type II) substances, seven mucilage polysaccharides from selected plants were studied as follow: aerial parts of Basella alba Linn., fruits of Hibiscus esculentus Linn., leaves of Litsea glutinosa (Lour.) C.B. Robinson, seeds of Ocimum canum Sims., seeds of Plantago ovata Forssk., fruits of Scaphium scaphigerum G. Don. and seeds of Trigonella foenum-graecum Linn. The bioactive properties for entrapping glucose, inhibiting enzyme alpha-glucosidase and free radical scavenger were in vitro studied compared to glucomannan. The physical characteristics for water holding capacity and viscosity were determined. The chemical characteristics were assayed for monosaccharide composition using methanolysis, TMSderivatization and gas chromatography. O. canum mucilage superiorly entrapped glucose compared to glucomannan. This activity was relevant to its highly viscous gelation. S. scaphigerum showed another property of alphaglucosidase inhibition. S. scaphigerum mucilage (0.5%) inhibited the enzyme activity by 82.6%, compared to 1-Deoxynorjirimycin (by 47.6%). Most mucilages, except O. canum and P. ovata, showed DPPH scavenging activity higher than glucomannan. Galacturonic acid was found in 3 from 7 mucilages namely B. alba, P. ovata and S. scaphigerum. Whereas rhamnose was common sugar found in all seven mucilages. Monosaccharide components of these mucilages were compared to the results from the previous reports. Sci

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“…Another study involving 60 patients with type 2 diabetes whose diets were supplemented with 25 g powdered fenugreek seeds per day for 24 weeks, patients with mild type 2 diabetes were benefitted the most and were able to completely withdraw from the use of oral medications and insulin. 47 Also, the hypoglycaemic effect of fenugreek has been shown by studies of Sharma et al, Bordia A et al, Sharma RD et al 23,24,48 These above studies except the one by Gupta et al, have used powdered fenugreek seeds, whereas in our study the hydro-alcoholic extract of fenugreek seeds was used; it could probably be associated with similar effects at lower dose.…”

Section: Glycaemic Controlmentioning

confidence: 57%

Comparative evaluation of glipizide and fenugreek (Trigonella foenum-graecum) seeds as monotherapy and combination therapy on glycaemic control and lipid profile in patients with type 2 diabetes mellitus

Singh

Rai

Mahajan

2016

Int J Basic Clin Pharmacol

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Background: Diabetes is commonly associated with dyslipidemia, which is one of the major risk factors of coronary heart disease (CHD), the leading cause of mortality in patients with type 2 diabetic. It is thus desirable that an anti-diabetic drug must provide good glycaemic control and in addition cause correction of dyslipidaemia, at the same time being safe. Fenugreek, a traditional drug has been found to have beneficial effect on glycaemic control as well as lipid profile and may be thus useful in such patients. The study was thus planned to further explore the effect of fenugreek seed on glycaemic control and lipid profile by comparing it with a standard anti-diabetic drug glipizide. Methods: This 12 week, prospective, randomized, open-label, parallel group comparative study was conducted on 60 patients with type 2 diabetes. The patients were randomized to receive either glipizide 5 mg once daily (group A, n=20), fenugreek seed extract 500 mg twice a day (group B, n=20), or a combination of glipizide 2.5 mg and fenugreek seed extract 500 mg once daily (group C, n=20). The primary endpoint were the change in fasting blood glucose (FBG), glycated haemoglobin (HbA1c), and lipid profile from baseline after 12 weeks of treatment. Results: A statistically significant decline in mean FBG levels (group A -33.97%, p<0.001; versus group B -24.62%, p<0.001; versus group C -29.96%, p<0.001), and in HbA1c levels (group A -12.98 %, p<0.0001; group B -9.38%, p<0.0001; and group C -10.62%, p<0.0001) was seen in all three treatment groups. Total cholesterol (TC) reduced non-significantly in group A (-0.98%, p=0.1982), whereas in group B (-5.66%, p<0.001) and group C (-3.87%, p<0.001) it decreased significantly. Non-significant reduction in plasma triglycerides (TG) were seen in group A (-0.74%, p=0.0669), and significant reductions were seen in both group B (-17.23%, p<0.001) and group C (-11.34%, p<0.001). Low density lipoproteins cholesterol (LDL-C) showed nonsignificant reductions in group A (-0.74%, p=0.5482), and significant reductions in both group B (-4.15%, p<0.001) and group C (-2.68%, p=0.0463). Highdensity lipoproteins cholesterol (HDL-C) showed non-significant changes in all three groups (group A -0.60%, p =0.1529; group B 0.65%, p=0.2072; and group C 0.76%, p = 0.0543). The adverse drug reactions seen were mild in nature and none of the patients was withdrawn from the study because of serious adverse drug reactions. Conclusions: Monotherapy with fenugreek produced significant improvement in glycaemic control and dyslipidaemia. Glipizide monotherapy was more efficacious in controlling FBG and HbA1c levels than fenugreek monotherapy or in combination with fenugreek; glipizide monotherapy had no effect on lipid profile whereas fenugreek monotherapy was more efficacious in controlling dyslipidaemia than in combination with glipizide. Both drugs as monotherapy or in combination were well-tolerated by the patients.

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Use of Fenuqreek seed powder in the management of non-insulin dependent diabetes mellitus

Cited by 98 publications

References 19 publications

Systematic Review of Herbs and Dietary Supplements for Glycemic Control in Diabetes

Systematic Review of Herbs and Dietary Supplements for Glycemic Control in Diabetes

In Vitro Glucose Entrapment and Alpha-Glucosidase Inhibition of Mucilaginous Substances from Selected Thai Medicinal Plants

Comparative evaluation of glipizide and fenugreek (Trigonella foenum-graecum) seeds as monotherapy and combination therapy on glycaemic control and lipid profile in patients with type 2 diabetes mellitus

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