Use of Fertility Drugs and Risk of Ovarian Cancer: Results from a U.S.-Based Case–Control Study

Kurta, Michelle L.; Moysich, Kirsten B.; Weissfeld, Joel L.; Youk, Ada O.; Bunker, Clareann H.; Edwards, Robert P.; Modugno, Francesmary; Ness, Roberta B.; Diergaarde, Brenda

doi:10.1158/1055-9965.epi-12-0426

Cited by 54 publications

(38 citation statements)

References 61 publications

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“…This resulted in the elimination of the following numbers of cases: breast (3 cases within 1 year, 31 within 2 years), endometrial (0,0), ovarian (0,3), in situ cervix (3, 17), invasive cervix (2, 5). These eliminations did not substantially change the interpretation of risks associated with different fertility treatments.…”

Section: Resultsmentioning

confidence: 99%

In vitro fertilization and risk of breast and gynecologic cancers: a retrospective cohort study within the Israeli Maccabi Healthcare Services

Brinton

Trabert

Shalev

et al. 2013

Fertility and Sterility

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Objective To assess long-term cancer risks associated with in vitro fertilization (IVF). Design Record-linkage study Setting Health maintenance organization in Israel Patients 87,403 women evaluated and/or treated for infertility on or after September 25, 1994 who were followed for cancer development through June 22, 2011: 522 breast, 41 endometrial, 45 ovarian, 311 in situ cervical and 32 invasive cervical cancers were identified. Intervention(s) None Main Outcome Measures Hazard ratios (HRs) for specific cancers Results We found no significant relationships of IVF exposures to the risks of breast, endometrial or ovarian cancers. Compared to women with no fertility treatment, the HR for ovarian cancer associated with IVF was 1.58 (95% CI 0.75–3.29), with higher risk among those receiving 4+ cycles (1.78, 95% CI 0.76–4.13). There was also a non-significantly elevated risk for endometrial cancer among women who received 1–3 IVF cycles (1.94, 0.73–5.12), but additional cycles were associated with lesser risk. In contrast, the risk of in situ cervical cancer was significantly reduced and invasive cervical cancer non-significantly reduced among women receiving IVF as well as other fertility treatments. Conclusions Our results regarding long-term effects were largely reassuring, but women receiving IVF should continue to be monitored given that the procedures involves potent ovulation stimulators and repeated ovarian punctures.

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Section: Resultsmentioning

confidence: 99%

In vitro fertilization and risk of breast and gynecologic cancers: a retrospective cohort study within the Israeli Maccabi Healthcare Services

Brinton

Trabert

Shalev

et al. 2013

Fertility and Sterility

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“…Based on the latest National Immunization Survey data in McLaughlin et al, 2007;Antoniou et al, 2009;Moorman et al, 2009;Jordan et al, 2010;Titus-Ernstoff et al, 2010;PermuthWey et al, 2011;Tsilidis et al, 2011;Jordan et al, 2012;Kurta et al, 2012;Le et al, 2012;Pieta et al, 2012;Weiderpass et al, 2012;Wilailak et al, 2012;Su et al, 2013). Some studies indicate that breastfeeding lowers risk of developing ovarian cancer (Risch et al, 1983;CSHS, 1987;Harlow et al, 1988;Gwinn et al, 1990;Whittemore et al, 1992;Siskind et al, 1997;Salazar-Martinez et al, 1999;Greggi et al, 2000;Modugno et al, 2001;Tung et al, 2003;Mills et al, 2004;Rossing et al, 2004;Huusom et al, 2006;McLaughlin et al, 2007;Moorman et al, 2009;Jordan et al, 2010;Titus-Ernstoff et al, 2010;Permuth-Wey et al, 2011;Jordan et al, 2012;Kurta et al, 2012;Pieta et al, 2012;Wilailak et al, 2012;Su et al, 2013), while many other studies observed no associations between breastfeeding and ovarian cancer risk (Mori et al, 1988;Booth et al, 1989;<...>…”

Section: Introductionmentioning

confidence: 99%

Breastfeeding and Ovarian Cancer Risk: a Systematic Review and Meta-analysis of 40 Epidemiological Studies

Li¹,

Du²,

Zhang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Asian Pac J Cancer Prev, 15 (12), 4829-4837 IntroductionBreastfeeding is the most common method by which mothers provide nutrition to newborn infants. Based on the latest National Immunization Survey data in 2012, the overall rate of initiation of breastfeeding in the United States is 76.9% (CDC). The most significant effect of breastfeeding on maternal health is the reduced risk of developing breast cancer (Bernier et al., 2000; Collaborative Group on Hormonal Factors in Breast, 2002;do Carmo Franca-Botelho et al., 2012). Studies of the overall effect of breastfeeding on maternal outcomes also suggest that breastfeeding decreases the risk of developing hypertension, hyperlipidemia, cardiovascular disease and diabetes (Schwarz et al., 2009). Infant could also benefit from long-term breastfeeding, e.g. prevention of Childhood Hodgkin Lymphoma (Wang et al., 2013).Ovarian cancer is the sixth most common cancer and the seventh-leading cause of cancer-related deaths among women. The prognosis for ovarian cancer is poor, with a 5-year survival rate of less than 45% (Jemal et al., 2011), and the causes of the disease are not understood. There

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“…An increased risk of ovarian cancer with ovulation-inducing drug use was suggested in two early studies (2, 3), whereas recent cohort studies among infertile women suggest no association (4–10). Concerns, however, persist given reports of increased risk among certain subgroups of women, namely increased risk among women who remain nulligravid despite ovulation-inducing drug use (2, 11–13), increased risk with extended follow-up (12), and increased risk of borderline ovarian tumors (3, 9, 14, 15). The inconsistent results may be due to methodological limitations of the studies.…”

mentioning

confidence: 99%

Ovulation-inducing drugs and ovarian cancer risk: results from an extended follow-up of a large United States infertility cohort

Trabert

Lamb

Scoccia

et al. 2013

Fertility and Sterility

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Objective To examine the relationship of ovulation-inducing drugs and ovarian cancer. Design Retrospective cohort study, with additional follow-up since initial report. Setting Five large reproductive endocrinology practices. Patient(s) In a retrospective cohort of 9,825 women evaluated for infertility at five clinical sites in the United States between 1965 and 1988 with follow-up through 2010, we examined the relationship of ovulation-inducing drugs and ovarian cancer (n = 85). Intervention(s) None. Main Outcome Measure(s) Hazard rate ratios (RR) and 95% confidence intervals (CI) for ovarian cancer. Result(s) Among women evaluated for infertility, there was no association of ovarian cancer risk with ever use of clomiphene citrate (CC) (adjusted RR 1.34, 95% CI 0.86–2.07) or gonadotropins (RR 1.00, 95% CI 0.48–2.08) and no evidence that any of several more detailed subgroups of usage were related to an increased risk with one exception: women who used CC and remained nulligravid did demonstrate much higher risks than those who successfully conceived compared with nonusers (respectively, RR 3.63, 95% CI 1.36–9.72 vs. RR 0.88, 95% CI 0.47–1.63). Conclusion(s) Our overall results were reassuring and consistent with other studies. A reason for an association between CC use and ovarian cancer among persistently nulligravid women remains to be determined. Given the large and increasing number of women treated with ovulation-inducing drugs, the increased risk of ovarian cancer among the subset of women who remained nulligravid should be further monitored.

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Use of Fertility Drugs and Risk of Ovarian Cancer: Results from a U.S.-Based Case–Control Study

Cited by 54 publications

References 61 publications

In vitro fertilization and risk of breast and gynecologic cancers: a retrospective cohort study within the Israeli Maccabi Healthcare Services

In vitro fertilization and risk of breast and gynecologic cancers: a retrospective cohort study within the Israeli Maccabi Healthcare Services

Breastfeeding and Ovarian Cancer Risk: a Systematic Review and Meta-analysis of 40 Epidemiological Studies

Ovulation-inducing drugs and ovarian cancer risk: results from an extended follow-up of a large United States infertility cohort

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