Use of finger‐piece method for indocyanine green clearance test

Sagawa, Eri; Okubo, Hironao; Sorin, Yushi; Nakadera, Eisuke; Fukada, Hiroo; Igusa, Yuki; Kokubu, Shigehiro; Miyazaki, Akira; Watanobe, Ikuo; Sugo, Hiroyuki; Kojima, Kuniaki; Watanabe, Sumio

doi:10.1111/hepr.12858

Cited by 9 publications

(7 citation statements)

References 24 publications

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“…Because such patients have a low possibility of showing abnormal ICGR15. A simplified ICG test using the finger‐piece or the nasal sensor would be accepted for these patients 29 . The platelet count and the ALBI grade are available even at the first consultation for hepatectomy because it uses basic blood tests.…”

Section: Discussionmentioning

confidence: 99%

“…A simplified ICG test using the fingerpiece or the nasal sensor would be accepted for these patients. 29 The platelet count and the ALBI grade are available even at the first consultation for hepatectomy because it uses basic blood tests. The early evaluation of the ALBI grade and the PLT-ALBI score can fasten and simplify the decision-making for hepatectomy.…”

Section: Discussionmentioning

confidence: 99%

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Application of albumin‐bilirubin grade and platelet count to indocyanine green‐based criteria for hepatectomy: Predicting impaired liver function and postoperative outcomes of hepatocellular carcinoma

Takamoto

Nara

Ban

et al. 2022

Journal of Surgical Oncology

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Background Applicability of the albumin‐bilirubin (ALBI) grade in preoperative decision‐making criteria based on the indocyanine green retention (ICG) test remains unclear. This study aimed to predict abnormal ICG values using standard blood tests and evaluate the impact on postoperative outcomes among patients undergoing hepatectomy for hepatocellular carcinoma (HCC). Methods Data on 949 consecutive HCC patients undergoing curative‐intent hepatectomy between 1996 and 2014 were retrospectively assessed. A nomogram using preoperative standard blood tests was created to predict abnormal ICGR15 (>15%). Results Three‐hundred nine patients had abnormal ICGR15. Predictors of abnormal ICGR15 included in the nomogram were: ALBI grade >1 (hazard ratio [HR]: 2.16, 95% confidence interval [CI]: 1.59–2.94), platelet count <130 000/mm3 (HR: 2.27, 95% CI: 1.68–3.08), aspartate aminotransferase >50 (IU/L) (HR: 1.90, 95% CI: 1.29–2.81), and viral hepatitis infection (HR: 1.46, 95% CI: 1.03–2.07). The nomogram named the PLT‐ALBI score was discriminative [C‐statistics: 0.719 (0.684–0.754)], and reliable (Hosmer‐Lemeshow Chi‐Square: 9.05, p = 0.338). The higher PLT‐ALBI score was associated with a more frequent incidence of clinically relevant posthepatectomy liver failure and poor overall survival. Conclusions The PLT‐ALBI score is applicable in distinguishing HCC patients with abnormal ICGR15. Patients with higher PLT‐ALBI score require more careful postoperative care, despite following the ICG criteria.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Application of albumin‐bilirubin grade and platelet count to indocyanine green‐based criteria for hepatectomy: Predicting impaired liver function and postoperative outcomes of hepatocellular carcinoma

Takamoto

Nara

Ban

et al. 2022

Journal of Surgical Oncology

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“…An ICG clearance metre has also recently been developed, in which a sensor is attached to the fingertip and the ICG concentration is measured using an optical sensor. [9][10][11] This method does not require blood sampling; however, a slightly weak correlation with the conventional method 9,11 and the high price of the device are disadvantageous.…”

Section: Discussionmentioning

confidence: 99%

Development of a simple indocyanine green measurement method using an automated biochemical analyser

et al. 2017

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Background The indocyanine green retention rate is important for assessing the severity of liver disorders. In the conventional method, blood needs to be collected twice. In the present study, we developed an automated indocyanine green method that does not require blood sampling before intravenous indocyanine green injections and is applicable to an automated biochemical analyser. Methods The serum samples of 471 patients collected before and after intravenous indocyanine green injections and submitted to the clinical laboratory of our hospital were used as samples. The standard procedure established by the Japan Society of Hepatology was used as the standard method. In the automated indocyanine green method, serum collected after an intravenous indocyanine green injection was mixed with the saline reagent containing a surfactant, and the indocyanine green concentration was measured at a dominant wavelength of 805 nm and a complementary wavelength of 884 nm. Results The coefficient of variations of the within- and between-run reproducibilities of this method were 2% or lower, and dilution linearity passing the origin was noted up to 10 mg/L indocyanine green. The reagent was stable for four weeks or longer. Haemoglobin, bilirubin and chyle had no impact on the results obtained. The correlation coefficient between the standard method (x) and this method (y) was r=0.995; however, slight divergence was noted in turbid samples. Conclusion Divergence in turbid samples may have corresponded to false negativity with the standard procedure. Our method may be highly practical because blood sampling before indocyanine green loading is unnecessary and measurements are simple.

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“…The standard deviation of measured concentration depending on the real dye concentration in the tissue can be visualized as an exponential curve ( Figure 4 ). The dependence is constructed within the range of regular dye concentrations used in medical diagnostics [ 2 , 3 , 4 , 6 , 7 , 8 , 9 ]. The curve given by Equation (12) shows that the concentration determination error rises dramatically with the increase of colorant concentration.…”

Section: Methodsmentioning

confidence: 99%

“…Although this method is frequently used, it has many disadvantages including high hygiene demands, a long time required for analysis, and the necessity for sophisticated spectrometric equipment, making it ineffective for prompt medical decisions. To avoid these limitations, we can use non-invasive monitoring based on optical pulse densitometry [ 7 ]. In this method, light is transmittedthrough the patient’s tissue, at a wavelength selected based on the absorption spectrum of the dye.…”

Section: Introductionmentioning

confidence: 99%

Joint Methodology Based on Optical Densitometry and Dynamic Light Scattering for Liver Function Assessment

et al. 2023

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A pressing health problem, both in clinical and socio-economic terms, is the increase in the number of patients with liver damage caused by viral diseases (hepatitis), cancer, toxicological damage, or metabolic disorders. Liver function assessment is a complex task, for which various existing diagnostic methods are used. Unfortunately, they all have several limitations which frequently make prompt and accurate diagnosis impossible. The high level of disability and mortality caused by liver diseases makes the development of new liver diagnostic methods very urgent. In this paper, we describe a new joint methodology for studying liver function based on optical densitometry and dynamic light scattering. This will help to diagnose and predict the dynamics of liver function during treatment with greater efficiency, due to including in consideration the individual characteristics of the cardiovascular system and tissue metabolism. In this paper, we present a laboratory model of a combined sensor for optical densitometry and dynamic light scattering. We also developed special software for controlling the sensor and processing the recorded data. Modeling experiments and physical medical studies were carried out to adjust and calibrate the sensor and software. We also assessed the sensor resolution when registering the concentration of dye in the human body and the minimum measured flow rate.

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Use of finger‐piece method for indocyanine green clearance test

Abstract: The ICG FPM may be an alternative to the ICG BSM for liver function assessment.

Cited by 9 publications

References 24 publications

Application of albumin‐bilirubin grade and platelet count to indocyanine green‐based criteria for hepatectomy: Predicting impaired liver function and postoperative outcomes of hepatocellular carcinoma

Application of albumin‐bilirubin grade and platelet count to indocyanine green‐based criteria for hepatectomy: Predicting impaired liver function and postoperative outcomes of hepatocellular carcinoma

Development of a simple indocyanine green measurement method using an automated biochemical analyser

Joint Methodology Based on Optical Densitometry and Dynamic Light Scattering for Liver Function Assessment

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