Use of focused beam reflectance measurement (FBRM) and process video imaging (PVI) in a modified mixed suspension mixed product removal (MSMPR) cooling crystallizer

Kougoulos, E.; Jones, Alan G.; Jennings, Kevin H.; Wood-Kaczmar, M.W.

doi:10.1016/j.jcrysgro.2004.09.032

Cited by 89 publications

(59 citation statements)

References 6 publications

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“…The Focused Beam Reflectance Measurement (FBRM) is a well-established method which has found extensive usage in online and in situ particle characterisation within the pharmaceutical and fine chemicals (Kougoulos et al, 2005;Nagy et al, 2008;Saleemi et al, 2012), food (Haddad Amamou et al, 2010;Arellano et al, 2012;Ndoye et al, 2013;Ndoye and Alvarez, 2015) and biotechnology industries (McDonald et al, 2001;Pearson et al, 2003;Jeffers et al, 2003;Whelan et al, 2012). This technique operates on the principle of laser backscattering wherein a laser beam scans in a circular path at a fixed speed through a probe immersed in the solution under study.…”

mentioning

confidence: 99%

In situ CHARACTERISATION OF PALM OLEIN CRYSTALLISATION BEHAVIOUR BY FOCUSED BEAM REFLECTANCE MEASUREMENT (FBRM)

Hishamuddin¹

2016

JOPR

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confidence: 99%

In situ CHARACTERISATION OF PALM OLEIN CRYSTALLISATION BEHAVIOUR BY FOCUSED BEAM REFLECTANCE MEASUREMENT (FBRM)

Hishamuddin¹

2016

JOPR

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“…It can be used off-line but also on-line and even in-line in a mill pipe [32][33][34] . The device can be inserted directly into a process stream with minimal disruption of the flow.…”

Section: Particle Vision and Measurementmentioning

confidence: 99%

New Tool To Monitor Biofilm Growth in Industrial Process Waters

Blanco

Herrera-Torres

Fuente

et al. 2011

Ind. Eng. Chem. Res.

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A new online methodology based on a continuous process video microscopy and image analysis has been developed to study the effects of enzymes on the formation of biofilm. This research consists of two parts: (1) the monitoring of the growth of a biofilm formed with the axenic culture isolated from the process waters of a recycling paper mill, aiming at determining the most appropriate way to quantify the biofilm growth from the obtained images; and (2) the study of the effects of three new enzymatic products on biofilm formation involving the natural flora of microorganisms present in the process water of the paper mill. The results demonstrate that the new methodology based on image analysis allows monitoring the formation of biofilm and selecting the most efficient biofilm control product. The study also shows that enzymatic products could be an alternative for biocides on biofilm prevention and control.

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“…The first involved the design of a modified MSMPR, incorporating a baffled heat exchanger to minimize temperature variations that can occur when incoming feed solution at higher temperature enters the MSMPR operating at lower temperature. Fouling and encrustation occur by the following mechanisms: (1) adsorption onto a surface prone to fouling/encrustation, (2) adsorption on heterogeneous and secondary nuclei that come into contact with the surface, and (3) alteration of the surface structure of the nuclei and crystals. 17 The second approach to fouling and encrustation prevention involved the use of an additive to control the crystallization kinetics.…”

Section: Introductionmentioning

confidence: 99%

Monitoring Continuous Crystallization of Paracetamol in the Presence of an Additive Using an Integrated PAT Array and Multivariate Methods

Powell

Saleemi²,

Rielly

et al. 2016

Org. Process Res. Dev.

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In this study, an automated intelligent decision support (IDS) framework was applied to monitor the continuous crystallization of form I paracetamol (PCM) and determine steady-state operation. A modified single-stage mixed suspension mixed product removal (MSMPR) crystallizer was used to investigate methods to minimize early onset of fouling and encrustation by carrying out crystallizations in the presence and absence of hydroxyl propyl methyl cellulose (HPMC) additive. The effectiveness of HPMC toward controlling the crystallization process and alleviating fouling and encrustation for prolonged operation of the MSMPR was investigated over a range of concentrations. HPMC was found to suppress nucleation and growth, thereby controlling the crystallization and alleviating fouling and encrustation over extended operating periods. HPMC also affected the product crystal morphology, leading to predominantly tabular shaped crystals. Steady state in the MSMPR was characterized using the IDS, which consisted of an integrated and ancillary array of process analytical technologies (PAT), including the application of Raman spectroscopy with multivariate calibration for solution phase concentration measurement.

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Use of focused beam reflectance measurement (FBRM) and process video imaging (PVI) in a modified mixed suspension mixed product removal (MSMPR) cooling crystallizer

Cited by 89 publications

References 6 publications

In situ CHARACTERISATION OF PALM OLEIN CRYSTALLISATION BEHAVIOUR BY FOCUSED BEAM REFLECTANCE MEASUREMENT (FBRM)

In situ CHARACTERISATION OF PALM OLEIN CRYSTALLISATION BEHAVIOUR BY FOCUSED BEAM REFLECTANCE MEASUREMENT (FBRM)

New Tool To Monitor Biofilm Growth in Industrial Process Waters

Monitoring Continuous Crystallization of Paracetamol in the Presence of an Additive Using an Integrated PAT Array and Multivariate Methods

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