Use of grapevine cell cultures for the production of phytostilbenes of cosmetic interest

Jeandet, Philippe; Clément, Christophe; Tisserant, Leo-Paul; Crouzet, Jérôme; Courot, Eric

doi:10.1016/j.crci.2016.02.013

Cited by 36 publications

(36 citation statements)

References 72 publications

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“…The level of t‐ resveratrol production in the V. amurensis calli treated with Cin acid was 1.4–1.7 times higher than that in the SA‐ or MeJa‐treated calli . The Cin acid induced increase in production of t‐ resveratrol was approximately at the same level as the CA‐induced improvement in production of t‐ resveratrol , but the Cin acid induced effect was lower than the level of t‐ resveratrol production in Escherichia coli transformed with an STS gene , and then in V. vinifera cell cultures treated with CDs [, ]. Probably, the application of phenolic precursors in combination with elicitors or CDs could considerably increase the content of stilbenes in grapevine cells.…”

Section: Resultsmentioning

confidence: 87%

“…The most significant success in increasing resveratrol content in plant cell cultures has been reached using cyclodextrins (CDs). Elicitation with the DIMEB, RAMEB, and CAVASOL®W7 resulted in high levels of resveratrol, more than 250 mg/g DW . However, high amounts of CDs, for example, 50 mM ∼67 g/L of DIMEB, have been used for the treatments, which is important considering the high price of CDs.…”

Section: Introductionmentioning

confidence: 99%

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Stilbene content and expression of stilbene synthase genes in cell cultures of Vitis amurensis treated with cinnamic and caffeic acids

Tyunin

Nityagovsky

Grigorchuk

et al. 2017

Biotech and App Biochem

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It has previously been shown that exogenous application of p-coumaric acid (CA), a precursor of phenolic compounds, improved stilbene production in cell cultures of Vitis amurensis. This study examines the effect of cinnamic (Cin) and caffeic (Caf) acids, which are also phenolic precursors, on stilbene biosynthesis in the cell cultures. Five stilbenes, t-resveratrol diglucoside, t-piceid (t-resveratrol glucoside), t-resveratrol, t-ε-viniferin, and t-δ-viniferin, were found in the treated and untreated cells. Cin acid increased the total stilbene production in the grape cell cultures 2.3-3.5 times in comparison with that in the untreated cells. Caf acid increased the total stilbene production by 1.8- to 1.9-fold, but this increase was not considerably different from stilbene production in the untreated cells. Cin acid affected the total stilbene production via a marked increase in the content of t-resveratrol diglucoside (up to 2.2 times), t-piceid (up to three times), t-resveratrol (up to 5.1 times), t-ε-viniferin (up to eight times), and t-δ-viniferin (up to 9.2 times). Transcription levels of VaSTS5, 6, 7, 8, and 10 genes considerably increased under 0.1, 0.25, and 0.5 mM Cin acid. These results indicate that Cin acid increased stilbene production in V. amurensis calli via a selective enhancement of STS gene expression.

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Section: Resultsmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Stilbene content and expression of stilbene synthase genes in cell cultures of Vitis amurensis treated with cinnamic and caffeic acids

Tyunin

Nityagovsky

Grigorchuk

et al. 2017

Biotech and App Biochem

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“…Other groups have already described this effect. 18,19 The application of these results in a 14 L bioreactor led to a lower RSV production of 72 mg L À1 with b-CD (15 g L À1 ) and MeJA (0.8 mM) 17 con-rming that a scaled-up optimization is necessary. CDs are able to activate the genes encoding enzymes from the stilbene pathway and this effect could be enhanced by MeJA addition.…”

Section: Introductionmentioning

confidence: 91%

Physico-chemical studies of resveratrol, methyl-jasmonate and cyclodextrin interactions: an approach to resveratrol bioproduction optimization

et al. 2018

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“…The bio-production of resveratrol and its derivatives in grapevine cell cultures has been reported as a promising biotechnological alternative to their plant extraction and chemical synthesis. Plant cell cultures have been used extensively for bio-production of valuable secondary metabolites under controlled conditions independent of climatic changes or soil conditions (Giri and Zaheer 2016;Hussain et al 2012;Jeandet et al 2016;Jeong et al 2018;Mulabagal and Tsay 2004;Murthy et al 2014). To date, elicitation with MJ combined with dimethyl-b-cyclodextrins (CD-M) has proven the most efficient approach for high production of resveratrol and its derivatives in grapevine cell cultures (Bru et al 2006;Lijavetzky et al 2008;Martinez-Esteso et al 2009;Martínez-Márquez et al 2016) (Donnez et al 2009;Lambert et al 2019).…”

Section: Introductionmentioning

confidence: 99%

Induced extracellular production of viniferins in grapevine cell culture medium by elicitation with methyl jasmonate and stevioside

Jeong

Park

et al. 2020

Preprint

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We report the high production of stilbenes, including resveratrol and viniferins, in grapevine (Vitis labruscana L.) cell cultures through elicitation with methyl jasmonate (MJ) and stevioside (STE). Methyl-β-cyclodextrin (CD-M) is widely used as a solubilizer for resveratrol production. For the first time, we used STE as a solubilizer for stilbene production in plant cell cultures. MJ was most effective in activating VvSTS expression and stimulating stilbene biosynthesis and induced accumulation of trans-piceid in the cells. High levels of trans-resveratrol and δ-viniferin production were observed in the culture medium when CD-M and STE, respectively, were used as solubilizers, but neither were significantly elevated within the cells. Maximum production of trans-resveratrol (12.2 mg/L) and δ-viniferin (892.2 mg/L) was observed 5 days after elicitation of cells with MJ and STE in shake flask cultures. Notably, predominant production of δ-viniferin and trans-resveratrol was observed in shake and static flask culture medium, respectively. Furthermore, stilbene compounds of resveratrol, e-viniferin, and δ-viniferin were mainly produced in a 3 L bioreactor culture following elicitation of cells with MJ and STE. These results provide new strategies for conditional, high-level production of resveratrol and viniferins in cell cultures by utilizing the solubilizing properties of STE or CD-M.

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Use of grapevine cell cultures for the production of phytostilbenes of cosmetic interest

Cited by 36 publications

References 72 publications

Stilbene content and expression of stilbene synthase genes in cell cultures of Vitis amurensis treated with cinnamic and caffeic acids

Stilbene content and expression of stilbene synthase genes in cell cultures of Vitis amurensis treated with cinnamic and caffeic acids

Physico-chemical studies of resveratrol, methyl-jasmonate and cyclodextrin interactions: an approach to resveratrol bioproduction optimization

Induced extracellular production of viniferins in grapevine cell culture medium by elicitation with methyl jasmonate and stevioside

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