Use of handgrip strength in the assessment of the muscle function of chronic kidney disease patients on dialysis: a systematic review

Leal, Viviane O.; Mafra, Denise; Fouque, Denis; Anjos, Luiz Antônio dos

doi:10.1093/ndt/gfq487

Cited by 140 publications

(118 citation statements)

References 27 publications

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“…HGS is known to decrease in patients with CKD. Uremic toxins such as β2-microglobulin, deficiency of carnitine, disturbances of electrolyte metabolisms, hemodynamic factors related to dialysis procedure, increased inflammation and acidosis may all cause lower values of HGS in HD patients (5,7). Low values of HGS were found to predict mortality in both nonuremic and uremic patients (15,16).…”

Section: Discussionmentioning

confidence: 99%

Handgrip Strength and Serum Uric Acid Levels are Associated with Dialysis-Malnutrition Scores in Chronic Hemodialysis Patients

Başçı¹,

Özkök²,

Kacar³

et al. 2017

Turk Neph Dial Transpl

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OBJECTIVE: Protein-energy-wasting (PEW) is common and contributes to increased mortality in hemodialysis (HD) patients. Herein we aimed to investigate the relationships between the parameters of malnutrition including dialysis malnutrition score (DMS), bioimpedance analysis (BIA), handgrip strength (HGS) in chronic HD patients. MATERIAL and METHODS:Forty chronic HD patients (mean age:58±18 years; males:22) were enrolled. Mid-arm circumference (MAC) measurements and BIA were performed. HGS was measured by a Jamar hydraulic hand dynamometer. RESULTS:HGS, MAC and uric acid levels were higher in patients with mild malnutrition compared to severe malnutrition group. Postdialysis creatinine was associated with lean body ratio (LBR) (r=0.56, p=0.002), DMS (r=-0.57, p=<0.001), HGS (r=0.73, p<0.001) and MAC (r=0.51, p=0.001). DMS was inversely correlated with HGS (r= -0.63, p<0.001), MAC (r= -0.48, p=0.002), total protein (r=-0.36, p=0.02) and uric acid levels (r=-0.54, p<0.001). In linear regression analysis (R 2 =0.58; p<0.001), HGS and uric acid were found to independently predict DMS. HGS was associated with MAC, LBR, uric acid and post-HD urea. HGS was negatively correlated with age, DMS, fat tissue ratio (FTR) and Kt/V. In linear regression analysis (R 2 =0.71; p<0.001), gender, DMS and MAC were found to independently predict HGS.CONCLUSION: HGS and uric acid were significantly associated with dialysis-malnutrition scores. HGS is an easy and reliable test for the evaluation of malnutrition in HD patients.KEy wORDS: Malnutrition, Hemodialysis, Handgrip strength, Dialysis malnutrition score, Uric acid Öz AMAÇ: Protein-enerji tükenmesi sendromu, hemodiyaliz (HD) hastalarında sıktır ve artmış mortalite ile ilişkilidir. Burada, el-sıkma gücünün (ESG); diyaliz malnütrisyon skoru (DMS) ve biyoimpedans analizi (BİA) gibi diğer malnütrisyon parametreleri ile ilişkisinin araştırılması amaçlanmıştır. GEREÇ ve yÖNTEMLER:Kırk kronik HD hastası (ortalama yaş: 58±18 yıl; erkek :22) çalışmaya katıldı. Orta-kol çevresi (OKÇ) ve BİA ölçümleri yapıldı. ESG, Jamar hidrolik el dinamometresi ile ölçüldü.BULGULAR: ESG, OKÇ ve ürik asit seviyeleri, hafif malnütrisyon grubunda, ciddi malnütrisyon grubuna göre daha yüksek saptandı. Postdiyaliz kreatinin seviyeleri, yağsız vücut oranı (YVO) (r=0,56, p=0,002), DMS(r= -0,57, p=<0,001), ESG(r=0,73, p<0,001) ve OKÇ(r=0,51, p=0,001) ile anlamlı olarak ilişkili bulundu. DMS ise ESG 63, p<0,001),48, p=0,002),36, p=0,02) ve ürik asit seviyeleri (r=-0,54, p<0,001) ile ters-ilişkili bulundu. Lineer regresyon analizinde (R 2 =0,58; p<0,001), ESG ve ürik asitin DMS'nin bağımsız öngörücüleri olduğu bulundu. ESG ile OKÇ, YVO, ürik asit ve post-HD üre değerleri ilişkiliydi. Buna karşın ESG; yaş, DMS, yağ doku oranı ve Kt/V ile ters ilişkili bulundu. Lineer regresyon analizinde (R 2 =0,71; p<0,001), cinsiyet, DMS ve OKÇ'nin ESG'nin bağımsız öngörücüleri oldukları gösterildi. SONUÇ: ESG ve ürik asit seviyeleri, diyaliz-malnütrisyon skorlarıyla anlamlı olarak ilişkilidir. ESG, HD hastalarında malnütr...

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Section: Discussionmentioning

confidence: 99%

Handgrip Strength and Serum Uric Acid Levels are Associated with Dialysis-Malnutrition Scores in Chronic Hemodialysis Patients

Başçı¹,

Özkök²,

Kacar³

et al. 2017

Turk Neph Dial Transpl

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“…Hand grip strength is a method that assesses muscle strength and functional capacity 11,19 . It has been described as an appropriate tool for the nutritional screening and diagnosis of healthy populations 11,12 and hospitalized individuals 17 .…”

Section: Discussionmentioning

confidence: 99%

Relationship between hand grip strength and nutritional assessment methods used of hospitalized patients

et al. 2013

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OBJECTIVE: This study verified the association between hand grip strength and body mass index, subjective global assessment and nutritional risk screening 2002. METHODS: This cross-sectional study calculated the body mass index, measured hand grip strength and administered the subjective global assessment and nutritional risk screening 2002 to 118 patients hospitalized at the University Hospital of the Universidade Federal de Santa Catarina, Florianópolis, Brazil. Hand grip strength was compared with the reference values for the Brazilian population according to gender and age. The statistical analyses included the Student's t-test or Mann-Whitney test and multiple linear regression. The results were considered significant when p<0.05. RESULTS: The prevalences of nutritional risk or malnutrition according to body mass index, global subjective assessment, nutritional risk screening 2002 and hand grip strength were 3.5%, 50.9%, 33.9% and 35.6%, respectively. Malnourished individuals according to body mass index had, on average, 11.0kg less hand grip strength than the nourished individuals (p=0.008). There was no association between hand grip strength and the subjective global assessment (malnourished individuals had -2.8kg; p=0.078) and nutritional risk screening 2002 (malnourished individuals had -1.5kg; p=0.352). CONCLUSION: Hand grip strength was associated with body mass index but not with the subjective global assessment or nutritional risk screening 2002.

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“…Essa associação já era esperada uma vez que a creatinina sérica reflete os estoques de proteína somática e redução nos níveis de creatinina sérica em pacientes em HD sugerem déficit de massa muscular, fato que é agravado na presença de sinais de inflamação 5 . Marcadores inflamatórios mais elevados podem estimular a perda de aminoácidos e consequentemente a perda de proteínas das fibras musculares provocando efeitos adversos sobre a função muscular em pacientes em HD 4,30 . No presente estudo foi observado que o grupo de pacientes com sinais de inflamação teve menor média (18,5±7,2kg) de força muscular quando comparados com o grupo sem sinais de inflamação (22,9±8,9kg).…”

Section: Artigo Originalunclassified

Inflamação e associação com parâmetros clínicos e nutricionais de pacientes em hemodiálise

et al. 2017

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Use of handgrip strength in the assessment of the muscle function of chronic kidney disease patients on dialysis: a systematic review

Cited by 140 publications

References 27 publications

Handgrip Strength and Serum Uric Acid Levels are Associated with Dialysis-Malnutrition Scores in Chronic Hemodialysis Patients

Handgrip Strength and Serum Uric Acid Levels are Associated with Dialysis-Malnutrition Scores in Chronic Hemodialysis Patients

Relationship between hand grip strength and nutritional assessment methods used of hospitalized patients

Inflamação e associação com parâmetros clínicos e nutricionais de pacientes em hemodiálise

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