Use of high-density EEG in patients with Parkinson's disease treated with deep brain stimulation

Abstract

The number of reports on cognitive changes related to deep brain stimulation (DBS) surgery in Parkinson's disease (PD) is growing. The aim of the review was to assess whether high-density electroencephalography (HD EEG) in patients with DBS treatment for PD is used and mentioned as a research method for the assessment of cognitive function changes after DBS of the subthalamic nucleus. The HD EEG examination method demonstrates the effects of DBS on changes of connectivity among various areas of the brain using changes in bioelectric potentials recorded on the scalp during examination. The search results yielded seven studies on the possibility of using HD EEG to investigate changes in bioelectric potentials with various protocols (motor tasks, auditory stimuli). Based on the results, HD EEG appears to be a feasible research method in patients with PD and established DBS therapy. Therefore, we plan to use HD EEG to demonstrate the effects of DBS on changes of connectivity among various areas of the brain utilizing changes in bioelectric potentials recorded on the scalp during HD EEG examination.

Preoperative Electroencephalography‐Based Machine Learning Predicts Cognitive Deterioration After Subthalamic Deep Brain Stimulation

“…Our results further demonstrate that a standard 21‐channel EEG probably suffices to predict cognitive decline after STN DBS. Further insight into pathophysiological alterations underlying cognitive decline may be provided through source localization to more closely pinpoint anatomical substrates, 50,51 especially when combined with high‐density EEG setups or pre−post EEG settings 52 . However, these setups are less applicable in a clinical prediction setting which would have limited its current utility.…”

Closed-Loop Adaptive Deep Brain Stimulation in Parkinson’s Disease: Procedures to Achieve It and Future Perspectives

“…Cortical signals are recorded through noninvasive scalp electroencephalography (EEG) [116] or through invasive subdural electrocorticography (ECoG), which requires an implanted grid with contacts [117]. However, disturbance of the scalp makes the stability and consistency of EEG unable to fit the sufficiency requirement of input signal [118]. Thus, ECoG oscillations instead of EEG are utilized as input cortical signals of aDBS for PD [118,119].…”

“…However, disturbance of the scalp makes the stability and consistency of EEG unable to fit the sufficiency requirement of input signal [118]. Thus, ECoG oscillations instead of EEG are utilized as input cortical signals of aDBS for PD [118,119]. ECoG studies on PD patients revealed that high beta (20-30 Hz) power and gamma power are increased in M1 during movement tasks [120].…”