Use of high-resolution mass spectrometry for veterinary drug multi-residue analysis

Jongedijk, E.; Fifeik, Markus; Arrizabalaga-Larrañaga, Ane; Polzer, Joachim; Blokland, Marco; Sterk, S.S.

doi:10.1016/j.foodcont.2022.109488

Cited by 29 publications

(10 citation statements)

References 108 publications

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“…Based on analytical performance, Jongedijk et al [ 27 ] described the significant growth of the application of the technique for the analysis of residues of veterinary drugs and hormones in recent years, especially in the screening of multiple residues. This is a field that already has a high degree of confidence in its applicability in several European laboratories.…”

Section: Discussionmentioning

confidence: 99%

Critical Evaluation of Two Qualitative Analytical Approaches for Multiclass Determination of Veterinary Drugs in Bovine Muscle Using UHPLC-Q-Orbitrap: The Wind of Change in Brazilian Monitoring

Paula

Gondim

Schmidt³

et al. 2023

Molecules

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Food safety is recognized as a main requirement for consumers, food industries, and official laboratories. Here, we present the optimization and screening qualitative validation of two multianalyte methods in bovine muscle tissues by ultra-high-performance liquid chromatography coupled to high-resolution mass spectrometry with an Orbitrap-type analyzer, operated with a heated ionization source in positive and negative mode. This aims for not only the simultaneous detection of veterinary drugs regulated in Brazil but also the prospection of antimicrobials not yet monitored. Two different sample preparation procedures were applied: method A—generic solid-liquid extraction with 0.1% formic acid (v/v) in an aqueous solution of EDTA 0.1% (w/v)—acetonitrile-methanol (1:1:1, v/v/v), followed by an additional ultrasound-assisted extraction and method B—QuEChERS. In both procedures, selectivity showed satisfactory conformity. From a detection capability (CCβ) equivalent to ½ the maximum residue limit, >34% of the analyte resulted in a false positive rate of <5%, preponderant by the QuEChERS method, which exhibited a higher yield of the sample. The results showed the potential application of both procedures in the routine analysis of foods by official laboratories, enabling the expansion of this methodological portfolio as well as its analytical scopes, thus optimizing the control of residues of veterinary drugs in the country.

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Section: Discussionmentioning

confidence: 99%

Critical Evaluation of Two Qualitative Analytical Approaches for Multiclass Determination of Veterinary Drugs in Bovine Muscle Using UHPLC-Q-Orbitrap: The Wind of Change in Brazilian Monitoring

Paula

Gondim

Schmidt³

et al. 2023

Molecules

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“…Integrating the use of old and new technologies, such as liquid chromatographyultraviolet detection technology [75], high-performance liquid chromatography-fluorescence detection technology [76], liquid chromatography-mass spectrometry detection technology [77], high-resolution mass spectrometry detection technology [78], and enzymelinked immunosorbent detection technology [79], as well as nanotechnology [68] and multi-channel automated detection technology applications [80], can effectively improve flux analysis and detection sensitivity. It can effectively improve the effectiveness and quality of detecting veterinary drug residues.…”

Section: Fusion Of Multiple Detection Methodsmentioning

confidence: 99%

A Review of Veterinary Drug Residue Detection: Recent Advancements, Challenges, and Future Directions

Jun

Wan

2023

Sustainability

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Veterinary drug residues of common food (milk, meat) have posed serious threats to the environment and human health, making the quality and safety of agricultural, livestock, and aquatic products increasingly prominent. With the widespread use of veterinary drugs and the requirements for food safety, it has become urgent to detect veterinary drug residues in animal-derived foods. So far, few studies have systematically reviewed the progresses, challenges, and future directions in veterinary drug residue detection. A thorough review on the current advancements, challenges, and potential future directions of veterinary drug residue detection will be extremely beneficial and timely. This study reviewed recent developments of detection technology of veterinary drug residues. The current issues and challenges in veterinary drug residue detection were examined and highlighted. Finally, future proposals on directions and prospects for veterinary drug residue detection were suggested. High-throughput and high-sensitivity veterinary drug detection technology, sample pretreatment technology for rapid processing, and the fusion of multiple detection methods were recommended as the main directions for the future development of veterinary drug residue detection. It was suggested to develop the analysis and detection technologies of veterinary drug residue towards high automation, high sensitivity, and high throughput in the future. This review provides new ideas and strategies for the rapid development of animal husbandry industry and protecting consumers’ physical health and food safety.

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“…GCs have also been widely used in animal husbandry due to their anti-inflammatory, anti-shock, and anti-allergic properties. [12][13][14] Unfortunately, overuse of GCs might lead to the harmful residues in animal tissues and then enter the human body through the food chain, thus causing adverse effects including osteoporosis, endocrine disorders, immunosuppression, and disorders of glucose metabolism. [15][16][17][18] Hence, in order to ensure the human health, the European Union has established the maximum residue limits (MRLs) for GCs in animal tissues and foodstuffs.…”

Section: Introductionmentioning

confidence: 99%

“…Over the past few decades, the synthetic GCs commonly used in clinical practice included dexamethasone, betamethasone, prednisolone, and methylprednisolone, [9–11] as shown in Figure 1. GCs have also been widely used in animal husbandry due to their anti‐inflammatory, anti‐shock, and anti‐allergic properties [12–14] . Unfortunately, overuse of GCs might lead to the harmful residues in animal tissues and then enter the human body through the food chain, thus causing adverse effects including osteoporosis, endocrine disorders, immunosuppression, and disorders of glucose metabolism [15–18] .…”

Section: Introductionmentioning

confidence: 99%

Comparison of the Glucocorticoid Receptor Binding and Agonist Activities of Typical Glucocorticoids: Insights into Their Endocrine Disrupting Effects

Liang,

Li,

Zhang

et al. 2024

Chemistry & Biodiversity

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Over the past decades, the synthetic glucocorticoids (GCs) have been widely used in clinical practice and animal husbandry. Given the health hazard of these toxic residues in food, it is necessary to explore the detailed interaction mechanisms of typical GCs and their main target glucocorticoid receptor (GR). Hence, this work compared the GR binding and agonist activities of typical GCs. Fluorescence polarization assay showed that these GCs were potent ligands of GR. Their GR binding affinities were in the order of methylprednisolone > betamethasone ≈ prednisolone > dexamethasone, with IC50 values of 1.67, 2.94, 2.95, and 5.58 nM. Additionally, the limits of detection of dexamethasone, betamethasone, prednisolone, and methylprednisolone were 0.32, 0.14, 0.19, and 0.09 μg/kg in fluorescence polarization assay. Reporter gene assay showed that these GCs induced GR transactivation in a dose‐dependent manner, confirming their GR agonist activities. Among which, dexamethasone at the concentration of 100 nM produced a maximal induction of more than 11‐fold over the blank control. Molecular docking and molecular dynamics simulations suggested that hydrogen‐bonding and hydrophobic interactions played an important role in stabilizing the GC‐GR‐LBD complexes. In summary, this work might help to understand the GR‐mediated endocrine disrupting effects of typical GCs.

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Use of high-resolution mass spectrometry for veterinary drug multi-residue analysis

Cited by 29 publications

References 108 publications

Critical Evaluation of Two Qualitative Analytical Approaches for Multiclass Determination of Veterinary Drugs in Bovine Muscle Using UHPLC-Q-Orbitrap: The Wind of Change in Brazilian Monitoring

Critical Evaluation of Two Qualitative Analytical Approaches for Multiclass Determination of Veterinary Drugs in Bovine Muscle Using UHPLC-Q-Orbitrap: The Wind of Change in Brazilian Monitoring

A Review of Veterinary Drug Residue Detection: Recent Advancements, Challenges, and Future Directions

Comparison of the Glucocorticoid Receptor Binding and Agonist Activities of Typical Glucocorticoids: Insights into Their Endocrine Disrupting Effects

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