Use of inhaled nitric oxide to reduce pulmonary hypertension after heart transplantation

Foubert, L.; Latimer, R.D.; Oduro, A.; Gray, Stephen; Snow, David; Wallwork, J.; Large, Stephen

doi:10.1016/1053-0770(93)90351-k

Cited by 6 publications

(2 citation statements)

References 5 publications

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“…Because of immediate morbidity and mortality due to pulmonary hypertension following cardiac transplantation, INO has a particular role to play [85,86] and has become a standard part of managing right ventricular failure [87]. The donor heart has to adapt to a new haemodynamic state, during which time the PVR may need to be modulated selectively.…”

Section: Post-cardiac Transplantationmentioning

confidence: 99%

“…As with other conditions, traditional vasodilator therapies, such as glyceryl trinitrate and prostacyclin, PGI 2 , are often associated with significant systemic hypotension, thus limiting their use [48,88]. It has been suggested that therapeutic response times are longer in the transplanted patient, possibly due to histological or structural changes in the lung [85]. In an acute comparison of prostaglandin E(1) and INO in patients undergoing cardiac transplantation, INO decreased pulmonary pressures and facilitated weaning from cardiopulmonary bypass to a significantly greater extent than PGE(1) [76].…”

Section: Post-cardiac Transplantationmentioning

confidence: 99%

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Inhaled nitric oxide in cardiology

Hayward

Keogh

Macdonald

2001

Expert Opinion on Investigational Drugs

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Inhaled nitric oxide (INO) allows selective pulmonary vasodilatation with rapidity of action. It is effective in the acute management of reversible pulmonary hypertension in cardiac medical and surgical patients and is also useful in assessing the pulmonary vasodilator capacity in patients with chronic pulmonary hypertension. This review will examine the role of INO in the management of cardiac patients, compared to alternatives where available. The use of INO in cardiac failure, post-operative cardiac patients, patients with congestive cardiac failure or congenital heart disease will also be reviewed. Newer alternatives with prolonged pulmonary activity and simpler administration are also discussed.

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Section: Post-cardiac Transplantationmentioning

confidence: 99%

Section: Post-cardiac Transplantationmentioning

confidence: 99%

Inhaled nitric oxide in cardiology

Hayward

Keogh

Macdonald

2001

Expert Opinion on Investigational Drugs

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Atrial natriuretic peptide and nitric oxide in children with pulmonary hypertension after surgical repair of congenital heart disease

Ivy

Kinsella

Wolfe

et al. 1996

The American Journal of Cardiology

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Inhaled nitric oxide in cardiology practice

Hayward

1999

Cardiovascular Research

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Inhaled nitric oxide allows selective pulmonary vasodilatation with rapidity of action. It is effective in the acute post-operative management of pulmonary hypertension in cardiac surgical patients and is also valuable in assessing the pulmonary vasodilator capacity in patients with chronic pulmonary hypertension. This review examines the current role of inhaled nitric oxide in cardiac medicine, discussing issues concerning its administration and toxicity, as well as a summary of clinical studies in cardiac patients. New roles, as a modifier of platelet and leukocyte function, post-thrombolysis and following lung transplantation are described. New agents and alternative therapies, which prolong pulmonary activity, are also discussed.

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Use of inhaled nitric oxide to reduce pulmonary hypertension after heart transplantation

Cited by 6 publications

References 5 publications

Inhaled nitric oxide in cardiology

Inhaled nitric oxide in cardiology

Atrial natriuretic peptide and nitric oxide in children with pulmonary hypertension after surgical repair of congenital heart disease

Inhaled nitric oxide in cardiology practice

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