Use of Isoniazid Chemoprophylaxis in Renal Transplant Recipients

Tuberculosis in Renal Transplant Recipients: The Evidence for Prophylaxis

“…1), of which six were nonrandomized or observational studies ( Table 2). One of these RCTs was reported twice, once in 2006 (21) and again in 2009 (22), in an analysis of the same patients but with a longer follow-up, albeit with slightly discrepant numbers. One of these RCTs was reported twice, once in 2006 (21) and again in 2009 (22), in an analysis of the same patients but with a longer follow-up, albeit with slightly discrepant numbers.…”

“…Five reports of four RCTs conducted from 1994 to 2009 were reviewed ( Table 4). After contacting the authors, we have used the later article (22) with the longer follow-up in our analysis. After contacting the authors, we have used the later article (22) with the longer follow-up in our analysis.…”

Mycobacterium Tuberculosis in Solid Organ Transplantation: Incidence before and after Expanded Isoniazid Prophylaxis

“…As reported by others, the use of "universal" isoniazid prophylaxis in living-related kidney transplantation in an endemic area resulted in reduced numbers of active tuberculosis after transplantation. [20][21][22] WHO estimates the incidence rates of tuberculosis in Saudi Arabia to be 14 per 100 000 in 2013 (range, 12-16 per 100 000). 13 The prevalence of LTBI (defined as TST reaction of ≥10 mm) in the general population was reported in a nationwide survey in 1993 to be 33% in people without prior BCG vaccination.…”

Infections After Kidney Transplantation: The Bug Bear Of Kidney Transplantation In Tropics

“…The benefit of INH prophylaxis in reducing incidence of post transplant TB in KTRs of TB -endemic region, over the risk of development of drug resistant TB with INH montherapy exposure is unclear. Despite proven protective efficacy in clinical trials in endemic countries such as India and Pakistan [39][40][41], INH primary prophylaxis is often not practiced due to fear of inducing primary INH resistance of Mycobacterium tuberculosis and the risk of INH hepatotoxicity. The incidence of drug resistance to INH and/or Rifampicin could be as high as 20% among Indian KTR with TB [42].…”