Use of Magnetic Forces to Promote Stem Cell Aggregation During Differentiation, and Cartilage Tissue Modeling

Fayol, Delphine; Frascá, G; Visage, Catherine Le; Gazeau, Florence; Luciani, Nathalie; Wilhelm, Claire

doi:10.1002/adma.201300342

Cited by 90 publications

(103 citation statements)

References 47 publications

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“…Of importance, the magnetization is also found to be capable of further promoting this effect, which hints that the magnetic effect should play a crucial role. Many studies have reported that the magnetic nanoparticles can promote the differentiation of marrow-derived stem cells toward osteoblasts [25][26][27]. We also utilized the Au nanoparticles to do the same experiments, but it was found that the LBL-assembled colloidal Au film was unbeneficial for the differentiation of cells.…”

Section: Resultsmentioning

confidence: 99%

Growth enhancing effect of LBL-assembled magnetic nanoparticles on primary bone marrow cells

Zhang

Tang³

et al. 2016

Sci. China Mater.

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Magnetic field has been considered to have positive effect on growth of bone. Because a magnetic nanoparticle can be regarded as one magnetic dipole, the macroscopic assemblies of magnetic nanoparticles may exhibit magnetic effect on local objects. This paper fabricated macroscopic film of γ-Fe2O3 nanoparticles by layer-by-layer (LBL) assembly on poly-D,L-lactic acid (PLA) scaffold, and studied the magnetic effect of the assembled γ-Fe2O3 nanoparticles film on primary bone marrow cells. The primary bone marrow cells were extracted from a mouse and cultured on the PLA substrate decorated by the film of γ-Fe2O3 nanoparticles after purification. Quantitative PCR (q-PCR) was used to show the cellular effect quantitatively. A just-found magnetosensing protein was employed to verify the magnetic effect of assembled film of nanoparticles on primary cells. It was exhibited that the decoration of nanoparticles enhanced the mechanical property of the interface. By acting as the adhesion sites, the LBL-assembled film of nanoparticles seemed beneficial to the cellular growth and differentiation. The expression of magnetosensing protein indicated that there was magnetic effect on the cells which resulted from the assembly of magnetic nanoparticles, implying its potential as a promising interface on scaffold which can integrate the physical effect with good biocompatibility to enhance the growth and differentiation of stem cells. The LBL-assembled film of magnetic nanoparticles may boost the development of novel scaffold which can introduce the physical stimulus into local tissue in vivo.

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Section: Resultsmentioning

confidence: 99%

Growth enhancing effect of LBL-assembled magnetic nanoparticles on primary bone marrow cells

Zhang

Tang³

et al. 2016

Sci. China Mater.

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“…magnetoelasticity | buckling | nanoparticles | instability | magnetic I n the past decade there has been an emerging field of research on new magnetic and elastic soft materials whose shape can be remotely controlled by application of an external magnetic field (1)(2)(3). Indeed, at many scales and in various domains, magnetic filaments (4,5), gels (6), and so on (7) show great promise in numerous domains of application (8). With the progress in the design of these materials, their magnetic susceptibility increases, and brings them closer to the behavior of the more conventional magnetic alloys.…”

mentioning

confidence: 99%

A refined theory of magnetoelastic buckling matches experiments with ferromagnetic and superparamagnetic rods

Gerbal

Wang

Lyonnet

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

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In its simplest form the magnetoelastic buckling instability refers to the sudden bending transition of an elastic rod experiencing a uniform induction field applied at a normal angle with respect to its long axis. This fundamental physics phenomenon was initially documented in 1968, and, surprisingly, despite many refinements, a gap has always remained between the observations and the theoretical expectations. Here, we first renew the theory with a simple model based on the assumption that the magnetization follows the rod axis as soon as it bends. We demonstrate that the magnetoelastic buckling corresponds to a classical Landau secondorder transition. Our model yields a solution for the critical field as well as the shape of the deformed rods which we compare with experiments on flexible ferromagnetic nickel rods at the centimeter scale. We also report this instability at the micrometer scale with specially designed rods made of nanoparticles. We characterized our samples by determining all of the relevant parameters (radius, length, Young modulus, magnetic susceptibility) and, using these values, we found that the theory fits extremely well the experimental results for both systems without any adjustable parameter. The superparamagnetic feature of the microrods also highlights the fact that ferromagnetic systems break the symmetry before the buckling. We propose a magnetic "stick-slip" model to explain this peculiar feature, which was visible in past reports but never detailed. magnetoelasticity | buckling | nanoparticles | instability | magnetic I n the past decade there has been an emerging field of research on new magnetic and elastic soft materials whose shape can be remotely controlled by application of an external magnetic field (1-3). Indeed, at many scales and in various domains, magnetic filaments (4, 5), gels (6), and so on (7) show great promise in numerous domains of application (8). With the progress in the design of these materials, their magnetic susceptibility increases, and brings them closer to the behavior of the more conventional magnetic alloys. Thus, they can benefit a more ancient domain of research that described their magnetoelastic properties. Magnetoelasticity generally describes various phenomena that couple magnetization and mechanical deformation of solid-state objects (9). Excluding magnetostriction, the domain splits into two categories depending on whether the system is driven by free macroscopic currents or only by bound currents. In this latter case, the system may be studied only for its equilibrium configuration, or for its dynamic behavior (10). The complexity of the solution of the magnetic field in the general case justifies that a comprehensive description of the phenomenon is restricted to some trivial geometries such as rods of large aspect ratios (11). The main contribution to the field was made in 1968 with an elegant work (12) that paved the way both for experiments and theory but whose measures showed a critical field twice lower than expected. Further studies (1...

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“…The first step of magnetic cell manipulation is to magnetically label cells by coculturing them with ferromagnetic particles. Then, by applying an external magnetic field, these magnetically tagged cells would organize to form defined cell patterns with certain sizes and shapes . For example, magnetically labeled human mesenchymal stem cells were observed to aggregate into rod‐like tissues or sheet‐like tissues under the impact of magnetic tips or magnetic sheets, respectively.…”

Section: Ferrofluid‐based Detection Diagnosis and Therapymentioning

confidence: 99%

Flexible Ferrofluids: Design and Applications

et al. 2019

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Ferrofluids, also known as ferromagnetic particle suspensions, are materials with an excellent magnetic response, which have attracted increasing interest in both industrial production and scientific research areas. Because of their outstanding features, such as rapid magnetic reaction, flexible flowability, as well as tunable optical and thermal properties, ferrofluids have found applications in various fields, including material science, physics, chemistry, biology, medicine, and engineering. Here, a comprehensive, in‐depth insight into the diverse applications of ferrofluids from material fabrication, droplet manipulation, and biomedicine to energy and machinery is provided. Design of ferrofluid‐related devices, recent developments, as well as present challenges and future prospects are also outlined.

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Use of Magnetic Forces to Promote Stem Cell Aggregation During Differentiation, and Cartilage Tissue Modeling

Cited by 90 publications

References 47 publications

Growth enhancing effect of LBL-assembled magnetic nanoparticles on primary bone marrow cells

Growth enhancing effect of LBL-assembled magnetic nanoparticles on primary bone marrow cells

A refined theory of magnetoelastic buckling matches experiments with ferromagnetic and superparamagnetic rods

Flexible Ferrofluids: Design and Applications

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