Use of melatonin versus valproic acid in prophylaxis of migraine patients: A double-blind randomized clinical trial

Abstract

The adjuvant treatment with melatonin was found to be superior to the placebo and had the same clinical efficacy as sodium valproate, but with higher tolerability. Melatonin may prove to be an efficient substitute for sodium valproate, as a chronic migraine prophylaxis.

Migraine Care in the Era of COVID‐19: Clinical Pearls and Plea to Insurers

“…In the event patients with cardiovascular disease are diagnosed with COVID‐19, individualized treatment decisions should be made according to each patient's hemodynamic status and clinical presentation 61 Melatonin : There are also studies indicating melatonin is useful for migraine prevention with few side effects 62,63 Zonisamide : Has been found to be effective in cases where people have not had as positive a response to topiramate and/or had side effects to topiramate 64‐66 …”

Melatonin for preventing primary headache: A systematic review

“…After the initial screening, 11 references were eligible for full‐text screening. Four RCTs were included totalizing 351 participants (66% female) with age ranging from 18 to 85 years. Three evaluated the effectiveness of melatonin in migraine patients and one in cluster headache.…”

“…Four RCTs were included totalizing 351 participants (66% female) with age ranging from 18 to 85 years. Three evaluated the effectiveness of melatonin in migraine patients and one in cluster headache. The seven remaining references were excluded: six were related to other study designs and one were a mention to an included study.…”

“…Overall the methodological quality of the included studies was varied. Two studies were classified as presenting high risk of attrition bias due to a high number of losses (more than 20%). One study were classified as having high risk of reporting bias due to differences between in the prespecified outcomes in the study protocol and the outcomes reported in the study.…”

“…Two studies were classified as presenting high risk of attrition bias due to a high number of losses (more than 20%). One study were classified as having high risk of reporting bias due to differences between in the prespecified outcomes in the study protocol and the outcomes reported in the study. Considering other potential sources of bias, only one study was classified as presenting high risk of bias since the authors excluded participants after the randomization.…”