Use of mesoporous cellular foam (MCF) in preparation of polymeric microspheres for long acting injectable release formulations of paliperidone antipsychotic drug

Nanaki, Stavroula; Tseklima, Maria; Terzopoulou, Zoi; Nerantzaki, Maria; Giliopoulos, Dimitrios; Triantafyllidis, Konstantinos S.; Kostoglou, Margaritis; Bikiaris, Dimitrios N.

doi:10.1016/j.ejpb.2017.03.016

Cited by 37 publications

(54 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Figure 6a shows the FT-IR spectra of the neat PLLA, galantamine and nanoparticles that were formed. As can be observed, PLLA showed its characteristic peaks, a double peak at 2998 and 2946 cm −1 due to the stretching vibrations of the >C-H bond and a peak at 1760 cm −1 due to the stretching vibrations of the >C=O bonds [22]. The spectra of the PLLA-GAL nanoparticles showed peaks at 2622, 1512, 1426, and 1384 cm −1 due to the galantamine (neat galantamine showed peaks at 2620, 1514, 1425 and 1385 cm −1 ).…”

Section: Polymeric Gal Loaded Nanoparticles Characterizationmentioning

confidence: 75%

“…The mass loss of the HPC at that range (268 to 600 • C) was 9.5%. From the above, we conclude that 21.5% wt of the GAL was adsorbed on the HPC [22]. Figure 3 shows the FT-IR spectra of the HPC, galantamine and HPC-GAL.…”

Section: Synthesis and Characterization Of Hpcmentioning

confidence: 76%

“…The spectra of the PLLA-GAL nanoparticles showed peaks at 2622, 1512, 1426, and 1384 cm −1 due to the galantamine (neat galantamine showed peaks at 2620, 1514, 1425 and 1385 cm −1 ). The FT-IR spectra of the PLGA (both 75/25 and 65/35 w/w) are shown in Figure 6b,c; a double peak at 2997 and 2952 cm −1 was due to the stretching vibration of >C-H, a peak at 1757 cm −1 was due to the stretching vibrations of the >C=O bonds and the aliphatic ether C-O-C stretch at 1088 cm −1 [22]. Small shifts from the original peaks in the neat materials to lower wavenumbers were observed for the galantamine-containing nanoparticles.…”

Section: Polymeric Gal Loaded Nanoparticles Characterizationmentioning

confidence: 99%

“…The ever-growing prevalence of AD and its detrimental effect on patients' quality of applications [16][17][18][19][20]. Furthermore, poly(lactide-co-glycolide) (PLGA), with lactide:glycolide ratios of 75/25 and 50/50 w/w has already been studied in microparticle preparation with paclitaxel [21] or paliperidone [22,23], an anticancer and an antipsychotic drug, respectively, either alone or by absorbing the drugs on silica-based nanoparticles (SBA-15 and MCF). The incorporation of the drugs in these nanoparticles and their further incorporation in polymeric microparticles was found to lead to the controlled release of the drugs.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Hierarchical Porous Carbon—PLLA and PLGA Hybrid Nanoparticles for Intranasal Delivery of Galantamine for Alzheimer’s Disease Therapy

et al. 2020

Self Cite

View full text Add to dashboard Cite

In the present study, poly(l-lactic acid) (PLLA) and poly(lactide-co-glycolide) (PLGA) hybrid nanoparticles were developed for intranasal delivery of galantamine, a drug used in severe to moderate cases of Alzheimer's disease. Galantamine (GAL) was adsorbed first in hierarchical porous carbon (HPC). Formulations were characterized by FT-IR, which showed hydrogen bond formation between GAL and HPC. Furthermore, GAL became amorphous after adsorption, as confirmed by XRD and differential scanning calorimetry (DSC) studies. GAL was quantified to be 21.5% w/w by TGA study. Adsorbed GAL was nanoencapsulated in PLLA and PLGA, and prepared nanoparticles were characterized by several techniques. Their sizes varied between 182 and 394 nm, with an exception that was observed in nanoparticles that were prepared by PLLA and adsorbed GAL that was found to be 1302 nm in size. DSC thermographs showed that GAL was present in its crystalline state in nanoparticles before its adsorption to HPC, while it remained in its amorphous phase after its adsorption in the prepared nanoparticles. It was found that the polymers controlled the release of GAL both when it was encapsulated alone and when it was adsorbed on HPC. Lastly, PLGA hybrid nanoparticles were intranasally-administered in healthy, adult, male Wistar rats. Administration led to successful delivery to the hippocampus, the brain area that is primarily and severely harmed in Alzheimer's disease, just a few hours after a single dose.

show abstract

Section: Polymeric Gal Loaded Nanoparticles Characterizationmentioning

confidence: 75%

Section: Synthesis and Characterization Of Hpcmentioning

confidence: 76%

Section: Polymeric Gal Loaded Nanoparticles Characterizationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Hierarchical Porous Carbon—PLLA and PLGA Hybrid Nanoparticles for Intranasal Delivery of Galantamine for Alzheimer’s Disease Therapy

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…Mesoporous silica nanomaterials (MSN) are currently studied for drug delivery applications due to their biosafety [1,2], high adsorption capacity [3][4][5], and possibility of tailoring the release profiles based on the interactions between the guest drug molecules and silica pore surface [6][7][8]. The most common methods of modifying the MSN properties include functionalization with organic groups [9][10][11][12][13], doping the silica framework with different atoms [14][15][16][17], or changing the morphologic and textural MSN properties, such as particle shape, pore size, specific surface area, total pore volume, or the pore arrangement and geometry [18][19][20][21][22][23][24][25]. Drug release from mesoporous carriers is a complex process, influenced by the structure of the therapeutic agent, the release medium, and the properties of the silica matrix [26][27][28].…”

Section: Introductionmentioning

confidence: 99%

Effect of Aluminum Incorporation into Mesoporous Aluminosilicate Framework on Drug Release Kinetics

Mitran

Berger

Pandele–Cușu

et al. 2017

Journal of Nanomaterials

View full text Add to dashboard Cite

Mesoporous silica materials are promising nanocarriers for the development of drug delivery systems. In this study, the influence of pore size, volume, surface area, and doping the silica framework on the release kinetics of a model drug, metoprolol, has been studied. 20% or 50% wt. therapeutic agent was loaded into the carrier mesopores through incipient wetness impregnation. The carriers and drug-loaded samples have been characterized by small-and wide-angle X-ray diffraction, FT-IR spectroscopy, scanning electron microscopy, and nitrogen adsorption-desorption isotherms. The in vitro release profiles have been fitted using a threeparameter kinetic model and they have been explained in terms of the release rate during the burst and sustained release stages and the fraction of drug molecules released during the burst stage. The silica framework doping with aluminum was found to decrease the amount of drug released in the burst stage, without affecting the other kinetic parameters. The therapeutic agent release rates depend mainly on the pore size and volume of the mesoporous carriers and drug-loaded samples.

show abstract

Injectable Mesocellular Foam Silica Microparticles with a Dual Role of Cell‐Recruiting Scaffolds and Intracellular Delivery Vehicles for Enhanced Cancer Vaccine

Im,

Choi,

Nguyen

et al. 2024

Adv Funct Materials

View full text Add to dashboard Cite

The cancer vaccine is one of the potent cancer immunotherapies based on provoking antigen‐specific adaptive immune responses in patients. Activating host antigen‐presenting cells by delivering antigens and adjuvants is one of the most important requirements to enhance cancer vaccine efficacy. This study proposes an effective cancer vaccine platform based on injectable mesocellular foam (MCF) silica microparticles with a dual role capable of in situ recruitment of host dendritic cells (DCs) and intracellular delivery of antigens to the recruited DCs. Subcutaneously administrated MCF microparticles loaded with chemoattractant to DCs (GM‐CSF), antigenic protein (OVA), and TLR9 agonist (CpG‐ODN) lead to robust DC maturation and high antigen‐specific T cell responses. The cell recruitment, DC activation, and T cell responses of MCF‐based cancer vaccine are significantly higher than injectable mesoporous silica scaffold, of which role is mostly limited to the cell recruiting scaffold. These features of MCF lead to effective inhibition of tumor growth in prophylactic vaccine setting and lung metastatic cancer model, representing MCF enabling cell‐recruiting scaffold formation and intracellular delivery of antigen can be a promising material platform for an enhanced cancer vaccine.

show abstract

Use of mesoporous cellular foam (MCF) in preparation of polymeric microspheres for long acting injectable release formulations of paliperidone antipsychotic drug

Cited by 37 publications

References 47 publications

Hierarchical Porous Carbon—PLLA and PLGA Hybrid Nanoparticles for Intranasal Delivery of Galantamine for Alzheimer’s Disease Therapy

Hierarchical Porous Carbon—PLLA and PLGA Hybrid Nanoparticles for Intranasal Delivery of Galantamine for Alzheimer’s Disease Therapy

Effect of Aluminum Incorporation into Mesoporous Aluminosilicate Framework on Drug Release Kinetics

Injectable Mesocellular Foam Silica Microparticles with a Dual Role of Cell‐Recruiting Scaffolds and Intracellular Delivery Vehicles for Enhanced Cancer Vaccine

Contact Info

Product

Resources

About