Use of Microarray Technology to Profile Gene Expression Patterns Important for Reproduction in Cattle

Evans, A.C.O.; Forde, Niamh; O'Gorman, Grace M.; Zielak, A. E.; Lonergan, Patrick; Fair, Trudee

doi:10.1111/j.1439-0531.2008.01185.x

Cited by 27 publications

(11 citation statements)

References 81 publications

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“…Thus, both the causing variable, most probably a factor secreted by the early embryo, and the purpose of the enhancement remain to be shown. By cautiously extrapolating in vitro findings, these results point towards an earlier maternal recognition of pregnancy appearing locally than previously described (Evans et al, 2008). Further studies are indicated.…”

supporting

confidence: 59%

Bovine endometrial metallopeptidases MMP14 and MMP2 and the metallopeptidase inhibitor TIMP2 participate in maternal preparation of pregnancy

Ulbrich

Meyer

Zitta

et al. 2011

Molecular and Cellular Endocrinology

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Bovine endometrial metallopeptidases MMP14 and MMP2 and the metallopeptidase inhibitor TIMP2 participate in maternal preparation of pregnancy. Molecular and Cellular Endocrinology, Elsevier, 2010, 332 (1-2) This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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supporting

confidence: 59%

Bovine endometrial metallopeptidases MMP14 and MMP2 and the metallopeptidase inhibitor TIMP2 participate in maternal preparation of pregnancy

Ulbrich

Meyer

Zitta

et al. 2011

Molecular and Cellular Endocrinology

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“…intra-genic mutations). Furthermore, knowledge of likely genes and biological pathways governing phenotypic differencing among animals are emerging from either genome-wide association studies (Berry et al, 2012), candidate gene studies (Waters et al, 2011) or transcriptomic studies (Evans et al, 2008). Such discoveries could be incorporated into a more supervised (e.g.…”

Section: Genomic Mating Plansmentioning

confidence: 99%

Genetics and genomics of reproductive performance in dairy and beef cattle

Berry

Wall

Pryce

2014

Animal

319

235

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Excellent reproductive performance in both males and females is fundamental to profitable dairy and beef production systems. In this review we undertook a meta-analysis of genetic parameters for female reproductive performance across 55 dairy studies or populations and 12 beef studies or populations as well as across 28 different studies or populations for male reproductive performance. A plethora of reproductive phenotypes exist in dairy and beef cattle and a meta-analysis of the literature suggests that most of the female reproductive traits in dairy and beef cattle tend to be lowly heritable (0.02 to 0.04). Reproductive-related phenotypes in male animals (e.g. semen quality) tend to be more heritable than female reproductive phenotypes with mean heritability estimates of between 0.05 and 0.22 for semenrelated traits with the exception of scrotal circumference (0.42) and field non-return rate (0.001). The low heritability of reproductive traits, in females in particular, does not however imply that genetic selection cannot alter phenotypic performance as evidenced by the decline until recently in dairy cow reproductive performance attributable in part to aggressive selection for increased milk production. Moreover, the antagonistic genetic correlations among reproductive traits and both milk (dairy cattle) and meat (beef cattle) yield is not unity thereby implying that simultaneous genetic selection for both increased (milk and meat) yield and reproductive performance is indeed possible. The required emphasis on reproductive traits within a breeding goal to halt deterioration will vary based on the underlying assumptions and is discussed using examples for Ireland, the United Kingdom and Australia as well as quantifying the impact on genetic gain for milk production. Advancements in genomic technologies can aid in increasing the accuracy of selection for especially reproductive traits and thus genetic gain. Elucidation of the underlying genomic mechanisms for reproduction could also aid in resolving genetic antagonisms. Past breeding programmes have contributed to the deterioration in reproductive performance of dairy and beef cattle. The tools now exist, however, to reverse the genetic trends in reproductive performance underlying the observed phenotypic trends.

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“…To facilitate the studies of changes in gene expression and move away from time-consuming procedures of SSH and subtracted cDNA libraries, the microarray technology developed in the 1990s to early 2000s (Fodor et al, 1993;Lockhart et al, 1996;Lipshutz et al, 1999;Kargul et al, 2001;VanBuren et al, 2002) proved very useful. Indeed, by now it is the most popular technique to study the dynamic changes of gene expression during early development (for recent reviews, see Adjaye, 2005;Aiba et al, 2006;Evans et al, 2008). At the same time, expansion of the genome sequencing projects for other chordate model organisms, together with production and representative sequencing of cDNA libraries from eggs or ovaries for these species permitted to add a second-phylogenetic-dimension to the studies of the oocyte cytoplasm's role in early development (Evsikov et al, 2006;Evsikov and Marin de Evsikova, 2009).…”

Section: Gene Expression During Oet: a Historical Perspectivementioning

confidence: 99%

Gene expression during the oocyte‐to‐embryo transition in mammals

Evsikov¹,

Evsikova²

2009

Molecular Reproduction Devel

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The seminal question in modern developmental biology is the origins of new life arising from the unification of sperm and egg. The roots of this question begin from 19 th -20 th century embryologists studying fertilization and embryogenesis. Although the revolution of molecular biology has yielded significant insight into the complexity of this process, the overall orchestration of genes, molecules, and cells, is still not fully formed. Early mammalian development, specifically the oocyte-to-embryo transition, is essentially under "maternal command" from factors deposited in the cytoplasm during oocyte growth, independent of de novo transcription from the nascent embryo. Many of the advances in understanding this developmental period occurred in tandem with application of new methods and techniques from molecular biology, from protein electrophoresis to sequencing and assemblies of whole genomes. From this bed of knowledge, it appears that precise control of mRNA translation is a key regulator coordinating the molecular and cellular events occurring during oocyte-to-embryo transition. Notably, oocyte transcriptomes share, yet retain some uniqueness, common genetic motifs among all chordates. The common genetic motifs typically define fundamental processes critical for cellular maintenance, whereas the unique genetic features may be a source of variation and a substrate for sexual selection, genetic drift, or gene flow. One purpose for this complex interplay among genes, proteins, and cells may allow for evolution to transform and act upon the underlying processes, at molecular, structural and organismal levels, to increase diversity, which is the ultimate goal of sexual reproduction.

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Use of Microarray Technology to Profile Gene Expression Patterns Important for Reproduction in Cattle

Cited by 27 publications

References 81 publications

Bovine endometrial metallopeptidases MMP14 and MMP2 and the metallopeptidase inhibitor TIMP2 participate in maternal preparation of pregnancy

Bovine endometrial metallopeptidases MMP14 and MMP2 and the metallopeptidase inhibitor TIMP2 participate in maternal preparation of pregnancy

Genetics and genomics of reproductive performance in dairy and beef cattle

Gene expression during the oocyte‐to‐embryo transition in mammals

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