In this study, we have analyzed the intervention effect of music on insomnia of college students. For this purpose, we have selected college students of grade 2019 facing insomnia in our school and randomly selected 96 of them as research objects after the informed consent of the students. 96 subjects were randomly divided into two groups, observation group and control group, 48 cases in each group. No music intervention was applied to the control group, while music intervention was applied to the observation group. After intervention, all college students in the observation group and the control group were given PSQI scale and filled it out. The score was collected on the spot and counted immediately to evaluate the intervention effect of music on college students’ insomnia. After music intervention, the score of each dimension of PSQI showed that the observation group was significantly better than the control group in falling asleep time, quality of sleep, hypnotic drugs, sleep efficiency, sleep disorders, and daytime dysfunction, and the results were statistically significant (
P
<
0.05
). There was a statistically significant difference in insomnia between the two groups (
P
<
0.05
), and the intervention efficacy of insomnia in the observation group was better than that in the control group. The observation group had a higher satisfaction with the insomnia intervention effect, and the total satisfaction was 89.58%. The control group had low satisfaction with the intervention effect of insomnia, the total satisfaction was 52.08%, and the difference was statistically significant (
P
<
0.05
). Through the application of the music intervention method, the sleep quality of college students had been improved, and the insomnia intervention effect was obvious; therefore, music intervention for college students’ insomnia had a good intervention effect and had the value of promotion.