Use of Nonsteroidal Anti-Inflammatory Drugs Following Exercise-Induced Muscle Injury

Lanier, Angela B.

doi:10.2165/00007256-200333030-00002

Cited by 69 publications

(16 citation statements)

References 88 publications

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“…On the other hand, if there is no secondary strength loss, more caution should be employed for such interventions because they might impair the recovery process. The results of our systematic review and meta-analysis may suggest why pharmacological, dietary, and therapeutic interventions have not been generally effective [23, 24], i.e., because there is minimal, if any, evidence for a secondary injury, at least not an injury resulting in an additional strength loss. This could be because the autogenetic and inflammatory phases may be constrained to lie within the initially damaged tissue and thus may be thought of as parts of the tissue repair and regeneration processes rather than degeneration processes that cause additional damage.…”

Section: Discussionmentioning

confidence: 99%

Minimal Evidence for a Secondary Loss of Strength After an Acute Muscle Injury: A Systematic Review and Meta-Analysis

et al. 2016

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BackgroundAn immediate loss of strength follows virtually all types of muscle injury but there is debate whether the initial strength loss is maximal or if a secondary loss of strength occurs during the first 3 days post-injury.ObjectiveThe objective of this analysis was to conduct a systematic review and meta-analysis of the research literature to determine if a secondary loss of strength occurs after an injurious initiating event.MethodsLiterature searches were performed using eight electronic databases (e.g., PubMed, Cochrane Library). Search terms included skeletal muscle AND (injur* OR damage*) AND (strength OR force OR torque). The extracted strength data were converted to a standard format by calculating the standardized mean difference, which is reported as the effect size (ES) along with its 95 % confidence interval (CI). The calculation of ES was designed so that a negative ES that was statistically less than zero would be interpreted as indicating a secondary loss of strength.ResultsA total of 223 studies with over 4000 human and animal subjects yielded data on 262 independent groups and a total of 936 separate ESs. Our overall meta-analysis yielded a small-to-medium, positive overall ES that was statistically greater than zero (overall ES = +0.34, 95 % CI 0.27–0.40; P < 0.00000001). Considerable variation in ES was observed among studies (I 2 = 86 %), which could be partially explained by the research group conducting the study, sex of the subject, day of post-injury strength assessment, whether fatigue was present immediately post-injury, and the muscle group injured. From the subgroup meta-analyses probing these variables, 36 subgroup ESs were calculated and none were statistically less than zero.ConclusionOverall, our findings do not support the presence of a secondary loss of strength following an acute muscle injury, and strongly suggest that strength, on average, recovers steadily over the first 3 days post-injury.Electronic supplementary materialThe online version of this article (doi:10.1007/s40279-016-0528-7) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Minimal Evidence for a Secondary Loss of Strength After an Acute Muscle Injury: A Systematic Review and Meta-Analysis

et al. 2016

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“…If the hypoalgesic mechanisms of ginger are predominantly peripheral, it is plausible that the oral dose given in the present study would require greater than 45 min to be absorbed, move to the peripheral site of injury (biceps) and exert an effect. While a single 5 mg/kg dose of caffeine has been shown to reduce exercise-induced muscle pain 60 min after administration (Maridakis et al, 2007), NSAIDS, which closely mimic the suggested pharmacological actions of ginger have not demonstrated a consistent hypoalgesic effect, with perhaps the best results occurring with prophylactic administration or chronic consumption over a several day period (Baldwin-Lanier, 2003;Connolly et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

Acute effects of dietary ginger on muscle pain induced by eccentric exercise

Black¹,

O’Connor²

2010

Phytotherapy Research

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Zingiber officinale, commonly known as ginger, has analgesic and antiinflammatory properties. The acute effects of ginger on muscle pain, inflammation and dysfunction induced by eccentric exercise were examined. Twenty-seven participants performed 24 eccentric actions of the non-dominant elbow flexors. In a double-blind, cross-over design, participants ingested a 2 g dose of ginger or placebo 24 h and 48 h after exercise. Pain intensity (0-100 mm), arm volume (water displacement), range-of-motion (goniometry) and metabolic rate were assessed before and 45 min after ingestion of ginger or placebo. Eccentric exercise induced moderate arm pain (39 ± 20 mm; mean ± SD) and dysfunction (14% decrease in ROM) and an increase in volume (1.8%). Overall, ginger consumption demonstrated no effect on muscle pain, dysfunction, or metabolic rate compared with placebo. In the sub-set of participants who consumed ginger 24 h after exercise, arm pain was reduced (13%, -5.9 ± 8.8 mm) the following day, 48 h after exercise. Participants who ingested placebo 24 h post-exercise exhibited no change in pain the following day (0.0 ± 14.7 mm). In conclusion, a single 2 g dose of ginger does not attenuate eccentric exercise-induced muscle pain, inflammation or dysfunction 45 min after ingestion. However, ginger may attenuate the day-to-day progression of muscle pain.

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“…Among these substances, CK is considered the best indicator of a breakdown in muscle cell structure [174]. However, the substantial individual variability in CK responses to the same exercise bouts could reduce the usefulness as a biomarker of players' recovery status [178].…”

Section: E Biochemical Markers (Biomarkers)mentioning

confidence: 99%

Fatigue and Recovery in Soccer: Evidence and Challenges

Marqués-Jiménez¹,

Calleja-González²,

Arratibel³

et al. 2017

Open Sports Sci. J.

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Background:Soccer presents physiological, metabolic, physical and psychological demands which can deteriorate players' performance due to fatigue. The high variability in physiological, metabolic, physical and psychological responses also influences the magnitude of exercise-induced muscle damage, with symptoms negatively affecting neuromuscular function during recovery or subsequent training sessions or matches. Consequently, more precise and consistent knowledge is required in this area to optimize training and performance. Objective:Therefore, the purpose is to sum-up current evidence on fatigue and recovery in soccer players, to shed light on factors that can affect players' performance, and to suggest applications for coaches and further research. Method:A comprehensive review of the scientific literature on the field was conducted. Results:Physical performance decrements during matches have traditionally been associated with physiological fatigue, but the magnitude of the symptoms in soccer players is unclear and depends on several factors. Moreover, the decline in physical performance during a soccer match is related to specific demands of each match. These could explain inter-individual variability in acute fatigue or training recovery processes when comparing players from the same team. Recovery counteracts the effects of fatigue, both peripheral and central, but there is a lack of consensus about the usefulness of tests used to monitor fatigue and recovery kinetics. Conclusion:Although fatigue and recovery in soccer has been extensively studied, there are still uncertainties about the underlying mechanisms because they are influenced by physiological and match-related demands.

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Use of Nonsteroidal Anti-Inflammatory Drugs Following Exercise-Induced Muscle Injury

Cited by 69 publications

References 88 publications

Minimal Evidence for a Secondary Loss of Strength After an Acute Muscle Injury: A Systematic Review and Meta-Analysis

Minimal Evidence for a Secondary Loss of Strength After an Acute Muscle Injury: A Systematic Review and Meta-Analysis

Acute effects of dietary ginger on muscle pain induced by eccentric exercise

Fatigue and Recovery in Soccer: Evidence and Challenges

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