Use of OPLC to study the biological activity of organic compounds

Abstract

Solute capacity factors in pure water, log k,,,,, determined by the new method based on Ogcik's equation, are proposed as descriptors of the biological activity of some benzamides. Values of log k,,,, determined by the new method and by parabolic extrapolation were compared with the minimum inhibitory concentration (M/C) of the compounds against six different dermatophytes, and correlations bel',,veen log k,,,, and log (1//VIIC) values of the same substances were analysed. For all the dermatophytes and all the compounds very good hnear correlations were obtained for retention factors determined by the method proposed in this study.

Liquid Chromatography in Studying Lipophylicity and Bioactivity of Pesticides

“…In the method the values of log k org, log k and x org are known (experimentally evaluated) and log k w parameter is determined by numerical fitting to equation 14 to obtain the linearity between the left term denoted as G and x org . We tested numerical method for different groups of substances, using various mobile and stationary phases by thin-layer, overpressured-layer and column reversed-phase chromatography techniques [Janicka, 2003;Janicka et al, 2006;Janicka, 2007) and numerical log k w parameters proved to be very good lipophylicity descriptors linear correlated to experimental and calculated log P values and moreover, in contrary to extrapolated, almost independent of the range of organic modifier concentration in the effluent.…”

Application of various methods to determine the lipophilicity parameters of the selected urea pesticides as predictors of their bioaccumulation

“…[1,2] Numerous research papers that have been published during the last years confirmed that the lipophilicity has significant impact on toxicity of organic compounds including pesticides and also on their bioaccumulation. [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] The relationship between bioaccumulation coefficient (K d ) of these compounds and partition coefficient (designated, e.g., as K ow or logP) determined by the use of proper method (theoretical or experimental) shows that described lipophilicity may correlate with bioaccumulation profile of pesticides according to Eq. (1):…”

The Effect of the Chain Length of Bonded Phase on Retention of Aromatic Solutes in Rp Lc With Pure Water as Mobile Phase

“…[12][13][14][15][16] However, the log k w values determined by these methods differ in dependence on the type of extrapolation function, the concentration range of the organic modifier for which chromatographic measurements were made, and the type of organic modifier. One of the alternative calculation methods of this parameter is the numerical method [17][18][19][20] based on the linear form of the Ościk's equation, [21] which was also used in this study.…”