Use of Oral Contraceptives in Women with Cystic Fibrosis

Fitzpatrick, Sherahe; Stokes, Dennis C.; Rosenstein, Beryl J.; Terry, Peter B.; Hubbard, Van S.

doi:10.1378/chest.86.6.863

Cited by 35 publications

(41 citation statements)

References 22 publications

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“…As the median age of survival increases, more females with CF reach child-bearing age and use OCs [19,20]. In our centre, ,43% of females with CF reported OC use at least once when …”

Section: Discussionmentioning

confidence: 58%

“…We are aware of only one comparatively small and short study, which assessed the effect of OCs on lung function. FITZPATRICK et al [19] studied 12 females using OCs and reported that lung function did not decline over a 6-month period. Our study was conducted over 5 yrs of follow-up, which may provide a better opportunity to observe either detrimental or beneficial effects of OCs on CF disease.…”

Section: Cystic Fibrosis Ng Kernan Et Almentioning

confidence: 99%

“…As the median age of survival increases, more females with CF reach child-bearing age and use oral contraceptives (OCs) [19,20]. The use of OCs by females with CF provides a clinical model in which to test the hypothesis that exogenous oestrogen and/or progesterone may have a significant clinical effect on the course of the disease.…”

mentioning

confidence: 99%

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Oral contraceptives do not appear to affect cystic fibrosis disease severity

et al. 2012

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Several studies suggest that sex may affect cystic fibrosis (CF) disease severity, with females with CF being more severely affected. In this context, it has been suggested that sex hormones may influence the CF phenotype. A large proportion of females with CF regularly use oral contraceptives (OCs), but the effect of their use on disease severity is unclear. Here, we retrospectively assessed the effects of OCs on clinical outcomes in females with CF.Data from 681 females were available, of whom 42% had taken OCs for varying periods of time. We first performed an inter-patient analysis comparing annual change in % predicted forced expiratory volume in 1 s, body mass index and total days of intravenous antibiotic use over a 5-yr study period in 57 females exposed to and 57 females not exposed to OCs. There were no differences between the two groups. We next performed an intra-patient analysis of the same outcomes over a 3-yr period of OC exposure and a 3-yr period of no OC exposure in the same patient (exposure followed by non-exposure, n527; non-exposure followed by exposure, n523), but again did not detect any differences in any of the clinical outcomes.Our data suggests that the use of OCs does not affect CF disease severity.

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“…As the median age of survival increases, more females with CF reach child-bearing age and use OCs [19,20]. In our centre, ,43% of females with CF reported OC use at least once when …”

Section: Discussionmentioning

confidence: 58%

Section: Cystic Fibrosis Ng Kernan Et Almentioning

confidence: 99%

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Oral contraceptives do not appear to affect cystic fibrosis disease severity

et al. 2012

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“…Plasma ethinyloestradiol and levonorgestrel concentrations were measured by means of previously described radioimmunoassays.10 " In the three patients taking contraceptive steroids the plasma concentration values obtained were corrected by subtraction of the concentrations detected before they took the study doses. The area under the plasma concentration-time curve from 0 to 24 hours (AUCO 24 In addition to the enhanced clearance of ethinyloestradiol, our results show an increased bioavailability of orally administered drug. The bioavailability of ethinyloestradiol was 76 9% (SD 11 7%) in patients with cystic fibrosis compared with 47.3% (7 5%) in controls (p < 0-001).…”

Section: Methodsmentioning

confidence: 68%

Pharmacokinetics of contraceptive steroids in patients with cystic fibrosis.

Stead¹,

Grimmer²,

Rogers³

et al. 1987

Thorax

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The pharmacokinetics of the commonly used contraceptive steroids ethinyloestradiol and levonorgestrel were investigated after oral and intravenous administration in six women with cystic fibrosis.The results were compared with data obtained from healthy women of similar age. The total body clearance of ethinyloestradiol was significantly higher in the patients with cystic fibrosis (0 61 (SD 0-19) 1/h/kg) than in control women (0-32 (0 16) 1/h/kg; p < 002). In addition, the oral bioavailability of ethinyloestradiol was greater in women with cystic fibrosis than in controls (76-9% (11 7%) compared with 47 3% (7-5%); p < 0-001). As a result of these two changes, the area under the plasma concentration-time curve after an oral dose of ethinyloestradiol was similar in patients and controls. The pharmacokinetics of levonorgestrel did not differ significantly between patients with cystic fibrosis and healthy women. The data suggest that women with cystic fibrosis will receive similar contraceptive protection from these steroids as do healthy women.

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“…10 The pharmacokinetics of the commonly used contraceptive steroids ethinylestradiol and levonorgestrel was investigated in six CF women. Although there was an increased total body clearance of ethinylestradiol, this was compensated for by increased oral bioavailability of the oestrogen.…”

Section: Contraceptionmentioning

confidence: 99%

Contraception and pregnancy in cystic fibrosis

Thorpe-Beeston

2009

J R Soc Med

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Use of Oral Contraceptives in Women with Cystic Fibrosis

Cited by 35 publications

References 22 publications

Oral contraceptives do not appear to affect cystic fibrosis disease severity

Oral contraceptives do not appear to affect cystic fibrosis disease severity

Pharmacokinetics of contraceptive steroids in patients with cystic fibrosis.

Contraception and pregnancy in cystic fibrosis

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