In this study the effects of natural and artificial pozzolans on alkali-silica reaction expansion of mortars were investigated by using the accelerated mortar bar test method in accordance with the ASTM C 1260. For this purpose, four natural pozzolans -ignimbrite powder (IG), perlite powder (PE), pumice powder (PU) and zeolite powder (ZE) -were used as cement at replacement levels of 0, 5, 10, 15, 20, 25, 30, 35 and 40% by weight of ordinary Portland cement. Four artificial pozzolans -fly ash (FA), brick powder (BP), silica fume (SF) and aerated concrete powder (AP) -were used at replacement levels of 0, 5, 10, 15, 20 and 25% by weight. The expansions of mortar bars were reduced as the replacement ratios of each natural and artificial pozzolans were increased, with the exception of specimens with a replacement level of 15, 20 and 25% AP. It is determined that at comparable replacement ratios SF is the most effective among the pozzolans used and is followed by PU, ZE, IG, PE, FA, BP and AP respectively.